Results 61 to 70 of about 126,705 (239)

The cholinergic anti-inflammatory pathway meets microRNA [PDF]

Cell Research, 2013
Acetylcholine is a cellular mediator selected early in evolution as a key neurotransmitter, but its other biological roles including immune-modulation remain to be elucidated. In a recent paper published in Cell Research, Sun et al. report that acetylcholine modulates cytokine production in macrophages via microRNA-124.
openaire   +2 more sources

COVID-19-related myocarditis and cholinergic anti-inflammatory pathways

Hellenic Journal of Cardiology, 2021
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2, is currently in a pandemic outbreak and has become a global health issue. In addition to the primarily involvement of the respiratory system, myocarditis is considered an important and fatal lesion in patients with COVID-19.
Liu, Weike, Liu, Zhendong, Li, Yue-Chun
openaire   +4 more sources

Noninvasive ultrasound stimulation to treat myocarditis through splenic neuro-immune regulation

Journal of Neuroinflammation, 2023
Background The cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are invasive or imprecise.
Tianshu Liu, Yanan Fu, Jiawei Shi, Shukun He, Dandan Chen, Wenqu Li, Yihan Chen, Li Zhang, Qing Lv, Yali Yang, Qiaofeng Jin, Jing Wang, Mingxing Xie   +12 more
doaj   +1 more source

The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation. [PDF]

Mol Med, 2019
Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammatory pathway (CAP) which inhibits inflammation ...
Hilderman M, Qureshi AR, Abtahi F, Witt N, Jägren C, Olbers J, Delle M, Lindecrantz K, Bruchfeld A.   +8 more
europepmc   +2 more sources

Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis [PDF]

Pharmacological Research, 2017
Sepsis is one of the main causes of mortality in hospitalized patients. Despite the recent technical advances and the development of novel generation of antibiotics, severe sepsis remains a major clinical and scientific challenge in modern medicine. Unsuccessful efforts have been dedicated to the search of therapeutic options to treat the deleterious ...
Alexandre, Kanashiro, Fabiane, Sônego, Raphael G, Ferreira, Fernanda V S, Castanheira, Caio A, Leite, Vanessa F, Borges, Daniele C, Nascimento, David F, Cólon, José Carlos, Alves-Filho, Luis, Ulloa, Fernando Q, Cunha   +10 more
openaire   +2 more sources

Presentation_1_The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay.pdf

, 2023
The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and immune cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA ...
Matteo Donegá (15288079), Margriet J. Vervoordeldonk (12890930), Thomas Simon (81007), Nikola Dolezalova (10489334), Justin Perkins (12722243), Arun Sridhar (8900048), Sandrine Hugues (15288073), Alexandre Bondue (15288067), Philippe Blancou (199052), Nicolas Glaichenhaus (239803), Mélanie Guyot (14916051), Eric Macia (15288076), Nicolas Hypolite (15243095), Julien Lavergne (15288070), Clara Panzolini (15243092), Kourosh Saeb-Parsy (7205267), Joseph Kirk (10489331)   +16 more
core   +1 more source

Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sinomenine (SIN), an alkaloid extracted from the Chinese herbal medicine Sinomenium acutum, has great potential in anti-inflammatory, immune regulation, analgesic and sedative, and is already a clinical drug for the treatment of rheumatoid arthritis in ...
Haojie Ni, Muqiu Liu, Mindie Cao, Lingyu Zhang, Yijing Zhao, Lang Yi, Yanwu Li, Liang Liu, Pei-xun Wang, Qun Du, Hua Zhou, Yan Dong   +11 more
semanticscholar   +1 more source

MOLECULAR MECHANISMS REGULATING LPS-INDUCED INFLAMMATION IN THE BRAIN

Frontiers in Molecular Neuroscience, 2016
Neuro-inflammation, one of the pathogenic causes of neurodegenerative diseases, is regulated through the cholinergic anti-inflammatory pathway via the 7 nicotinic acetylcholine receptor (7 nAChR).
Olena eLykhmus, Nibha eMishra, Lyudmyla eKoval, Olena eKalashnyk, Galyna eGergalova, Kateryna eUspenska, Serghiy eKomisarenko, Hermona eSoreq, Maryna eSkok   +8 more
doaj   +1 more source

Ultrasonic Stimulation of the Cholinergic Anti-Inflammatory Pathway for Renal Protection [PDF]

Journal of the American Society of Nephrology, 2013
AKI encompasses a large spectrum of pathophysiological processes starting from the early reversible proximal tubular lesion to the definite loss of glomerular filtration and even death. Even discrete AKI ( i.e.
Hougardy, Jean-Michel, Sadis, Claude, Le Moine, Alain   +2 more
openaire   +3 more sources

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Frontiers in Cellular Neuroscience, 2020
Background: Extracellular ATP is a powerful trigger of neuroinflammation by activating immune cells via P2X7 receptors. Acetylcholine and nicotinic agonists inhibit ATP-triggered proinflammatory cytokines via the so-called “cholinergic anti-inflammatory ...
Dilyara Nurkhametova, Dilyara Nurkhametova, Andrei Siniavin, Maria Streltsova, Denis Kudryavtsev, Igor Kudryavtsev, Igor Kudryavtsev, Raisa Giniatullina, Victor Tsetlin, Tarja Malm, Rashid Giniatullin, Rashid Giniatullin   +11 more
doaj   +1 more source