Results 51 to 60 of about 126,705 (239)

Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis. [PDF]

PLoS ONE, 2014
Activation of the cholinergic anti-inflammatory pathway, which relies on the α7nAchR (alpha 7 nicotinic acetylcholine receptor), has been shown to decrease proinflammatory cytokines.
Zheng Cheng, Ge Li-Sha, Zhao Jing-Lin, Zhang Wen-Wu, Chen Xue-Si, Chen Xing-Xing, Li Yue-Chun   +6 more
doaj   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

The Cholinergic Anti-Inflammatory Pathway as a Conceptual Framework to Treat Inflammation-Mediated Renal Injury

Kidney & Blood Pressure Research, 2019
Background: The cholinergic anti-inflammatory pathway, positioned at the interface of the nervous and immune systems, is the efferent limb of the “inflammatory reflex” which mainly signals through the vagus nerve.
Jonas Jarczyk, Benito A. Yard, Simone Hoeger   +2 more
doaj   +1 more source

Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation

Frontiers in Cellular Neuroscience, 2020
Aging is a complex biological process that increases the risk of age-related cognitive degenerative diseases such as dementia, including Alzheimer’s disease (AD), Lewy Body Dementia (LBD), and mild cognitive impairment (MCI).
Rashmi Gamage, Ingrid Wagnon, Ilaria Rossetti, Ryan Childs, Garry Niedermayer, Rose Chesworth, Erika Gyengesi   +6 more
doaj   +1 more source

New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength

Frontiers in Pharmacology, 2023
Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic ...
Shangkun Si, Xiaohu Zhao, Fan Su, Hongxiu Lu, Dongbin Zhang, Li Sun, Fulei Wang, Li Xu   +7 more
doaj   +1 more source

The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells

Frontiers in Immunology, 2017
Degeneration of central cholinergic neurons impairs memory, and enhancement of cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti-inflammatory, and neuroinflammation is increasingly linked to adverse memory, especially ...
Sara V. Maurer, Christina L. Williams
doaj   +1 more source

RETRACTED ARTICLE: nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse

Scientific Reports, 2021
An evaluation of the APPswe/PS1dE9 transgenic AD mouse, presenting with the toxic Aβ1-42 deposition found in human AD, allowed us to characterize time-dependent changes in inflammatory and cholinergic markers present in AD.
Chiara D’Angelo, Erica Costantini, Nieves Salvador, Michele Marchioni, Marta Di Nicola, Nigel H. Greig, Marcella Reale   +6 more
doaj   +1 more source

Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus

Frontiers in Medicine, 2021
There is a critical need for safe treatment options to control inflammation in patients with systemic lupus erythematosus (SLE) since the inflammation contributes to morbidity and mortality in advanced disease.
Jessica Y. Morales, Cassandra M. Young-Stubbs, Caroline G. Shimoura, William R. Kem, Victor V. Uteshev, Keisa W. Mathis   +5 more
doaj   +1 more source

Vagus nerve stimulation: from epilepsy to the cholinergic anti‐inflammatory pathway

Neurogastroenterology and Motility, 2013
International audienceBACKGROUND: The brain and the gut communicate bidirectionally through the autonomic nervous system (ANS). The vagus nerve (VN), a major component of the ANS, plays a key role in the neuro-endocrine-immune axis to maintain ...
B. Bonaz, C. Picq, V. Sinniger, J. Mayol, D. Clarençon   +4 more
semanticscholar   +2 more sources

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation

Neurobiology of Disease, 2009
Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRα7) by nicotine or acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation.
Eva-Maria Nicolussi, Sigismund Huck, Hans Lassmann, Monika Bradl   +3 more
doaj   +1 more source