Results 51 to 60 of about 3,652,668 (207)

Implications of a local overproduction of tumor necrosis factor-α in complex regional pain syndrome [PDF]

, 2011
Objective. To review the implications of a local overproduction of tumor necrosis factor-α for the pathogenesis and treatment of complex regional pain syndrome. Background.
Walker, S., Drummond, P.D.
core  

The Cholinergic Pathways in Inflammation: A Potential Pharmacotherapeutic Target for COPD

Frontiers in Pharmacology, 2018
In COPD, the activity of the cholinergic system is increased, which is one of the reasons for the airflow limitation caused by the contraction of airway smooth muscles.
Mitsuhiro Yamada, Masakazu Ichinose
doaj   +1 more source

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Frontiers in Cellular Neuroscience, 2020
Background: Extracellular ATP is a powerful trigger of neuroinflammation by activating immune cells via P2X7 receptors. Acetylcholine and nicotinic agonists inhibit ATP-triggered proinflammatory cytokines via the so-called “cholinergic anti-inflammatory ...
Dilyara Nurkhametova, Dilyara Nurkhametova, Andrei Siniavin, Maria Streltsova, Denis Kudryavtsev, Igor Kudryavtsev, Igor Kudryavtsev, Raisa Giniatullina, Victor Tsetlin, Tarja Malm, Rashid Giniatullin, Rashid Giniatullin   +11 more
doaj   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation. [PDF]

Mol Med, 2019
Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammatory pathway (CAP) which inhibits inflammation ...
Hilderman M, Qureshi AR, Abtahi F, Witt N, Jägren C, Olbers J, Delle M, Lindecrantz K, Bruchfeld A.   +8 more
europepmc   +2 more sources

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis

Frontiers in Physiology, 2020
Atherosclerosis constitutes a major risk factor for cardiovascular diseases, the leading cause of morbidity and mortality worldwide. This slowly progressing, chronic inflammatory disorder of large- and medium-sized arteries involves complex recruitment ...
Ildernandes Vieira-Alves, Leda M. C. Coimbra-Campos, Maria Sancho, Rafaela Fernandes da Silva, Steyner F. Cortes, Virgínia Soares Lemos   +5 more
doaj   +1 more source

Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone, RIC-3

Molecules, 2021
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation and cytokine release.
Tehila Mizrachi, Adi Vaknin-Dembinsky, Talma Brenner, Millet Treinin   +3 more
doaj   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. [PDF]

, 2007
Kidney ischemia/reperfusion injury (I/R) is characterized by renal dysfunction and tubular damages resulting from an early activation of innate immunity.
Geurt Stokman, Nike Claessen, Teske, Gwen, Claessen, Nike, Claude Sadis, Gwen Teske, Carole Kubjak, Diallo, Bilo, Fabrice Moore, Patrizia Loi, Michel Goldman, Barvais, Luc, Luc Barvais, Goldman, Michel, Bilo Diallo, Stokman, Geurt, Moore, Fabrice, Alain Le Moine, Loi, Patrizia, Florquin, Sandrine, Kubjak, Carole, Sandrine Florquin, Le Moine, Alain, Sadis, Claude   +23 more
core   +1 more source