Results 1 to 10 of about 2,532 (128)

Diabetes and Delayed Wound Healing: Molecular Mechanisms and Dermatological Interventions. [PDF]

Int Wound J
ABSTRACT Diabetes mellitus is a global burden that affects wound healing at nearly every stage, transforming what should be a coordinated and self‐limited repair process into a chronic, non‐healing state. In diabetic patients, sustained hyperglycemia drives persistent inflammation, impaired angiogenesis, fibroblast dysfunction and extracellular matrix ...
Jreije S, Fadel M, Karam C, Ghadieh HE, Ghanem A.   +4 more
europepmc   +2 more sources

An Update on the Correlation Between Neuroimmunomodulation, Photodynamic Therapy (PDT), and Wound Healing: The Role of Mast Cells [PDF]

Biomedicines
This review presents some aspects of the complex relationship between neuroimmunomodulation, photodynamic therapy, and wound healing. This relationship is important because photodynamic therapy, currently used to treat chronic wounds, has numerous ...
Montserrat Fernandez-Guarino, Luis Alonso-Mtz de Salinas, Jorge Naharro-Rodriguez, Stefano Bacci   +3 more
doaj   +2 more sources

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer. [PDF]

Immunology
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Barros ABB, Leite GA, de Andrade AG, Reis MDDS, Cavalcante-Silva LHA, Lins MP.   +5 more
europepmc   +2 more sources

Innate Immune Tolerance Regulates Microglia Response to Aβ Oligomers. [PDF]

J Neurochem
Microglia are the primary innate immune cells residing in the brain parenchyma, and their activation in Alzheimer's disease (AD) results in increased neuroinflammation. The development of innate immune memory in response to various stimuli is a crucial mechanism that allows microglia to tailor their responses to future inflammatory challenges.
Valerio RR, Santos ÁR, Nóbrega AHL, Martins R, De Felice FG, Ferreira ST, Savino W, Bonomo A, Bernardi A, Frozza RL.   +9 more
europepmc   +2 more sources

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. No disease‐modifying therapies exist. This review proposes that PD susceptibility begins with epigenetic changes and neuroimmune activity—factors that alter gene expression ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
doaj   +2 more sources

Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications

Frontiers in Aging Neuroscience, 2023
Vagus nerve stimulation (VNS) is a technology that provides electrical stimulation to the cervical vagus nerve and can be applied in the treatment of a wide variety of neuropsychiatric and systemic diseases.
Yi-Ting Fang, Yi-Jen Wu, Chao Ying-Jui   +2 more
exaly   +3 more sources

A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan [PDF]

Neuroimmunomodulation
Background: Extensive evidence from animal and human studies indicates that exposure to stress during sensitive developmental periods significantly increases the risk for psychiatric and physical disorders, resulting in reduced longevity ...
Sonja Entringer, Christine Heim
doaj   +2 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science
The intricacies of neuroimmunity underscore its pivotal role in the onset and progression of neurological diseases, yet its precise modulation remains a formidable challenge.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
doaj   +2 more sources

Immunological Approaches in the Diagnosis and Treatment of Psychiatric Disorders: A Historical Overview

Neuroimmunomodulation
Background: For over 130 years, scientists have been suggesting that infection and inflammation may play a role in psychosis and other psychiatric disorders.
Norbert Müller
doaj   +2 more sources

Acupuncture's Multisystem Neuroimmunomodulation: Central-Peripheral Interactions in Gastroenteric, Psychiatric, and Chronic Pain Disorders. [PDF]

CNS Neurosci Ther
This work elucidates acupuncture's multisystem therapeutic mechanisms through central‐peripheral crosstalk. Using functional gastrointestinal disorders, psychiatric disorders, and chronic pain models, we demonstrate its efficacy in rebalancing gut‐brain signaling, neuroimmune‐endocrine integration, and humoral network modulation.
Zhang L, Luo Y, Wei T, Wang D, He Z, Lan L, Zeng F.   +6 more
europepmc   +2 more sources