Results 21 to 30 of about 9,739 (239)

Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets

Frontiers in Pharmacology, 2023
Alzheimer’s disease (AD) is the most common form of neurodegenerative disease and disability in the elderly; it is estimated to account for 60%–70% of all cases of dementia worldwide.
Maylin Wong-Guerra, Maylin Wong-Guerra, Maylin Wong-Guerra, Camila Calfio, Camila Calfio, Ricardo B. Maccioni, Ricardo B. Maccioni, Leonel E. Rojo, Leonel E. Rojo, Leonel E. Rojo   +9 more
doaj   +1 more source

Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology

Frontiers in Cardiovascular Medicine, 2021
Since the early days of the pandemic, there have been several reports of cerebrovascular complications during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Saeideh Aghayari Sheikh Neshin, Shima Shahjouei, Eric Koza, Isabel Friedenberg, Faezeh Khodadadi, Mirna Sabra, Firas Kobeissy, Saeed Ansari, Georgios Tsivgoulis, Jiang Li, Vida Abedi, Vida Abedi, Donna M. Wolk, Ramin Zand   +13 more
doaj   +1 more source

In Vitro Effects of Cannabidiol on Activated Immune–Inflammatory Pathways in Major Depressive Patients and Healthy Controls

Pharmaceuticals, 2022
Major depressive disorder and major depressive episodes (MDD/MDE) are characterized by the activation of the immune–inflammatory response system (IRS) and the compensatory immune–regulatory system (CIRS).
Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Atapol Sughondhabirom, Kitiporn Plaimas, Apichat Suratanee, Michael Maes   +7 more
doaj   +1 more source

The Immune Profile of Major Dysmood Disorder: Proof of Concept and Mechanism Using the Precision Nomothetic Psychiatry Approach

Cells, 2022
Major depressive disorder and a major depressive episode (MDD/MDE) are characterized by activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS).
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Gałecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim   +7 more
doaj   +1 more source

Lymphocyte subsets and the role of Th1/Th2 balance in stressed chronic pain patients [PDF]

, 2007
Background: The complex regional pain syndrome (CRPS) and fibromyalgia (FM) are chronic pain syndromes occurring in highly stressed individuals. Despite the known connection between the nervous system and immune cells, information on distribution of ...
Alexander Chouker, Antje Beyer, Avgustin B, Brogden KA, Bruehl S, Buske-Kirschbaum A, Bussone G, Caggiula AR, Christoph Eisner, Elenkov IJ, Gage JR, Geertzen JH, Gilman-Sachs A, Grande LA, Gustav Schelling, Hamaty D, Harden RN, Hennig J, Herbert TB, Hudson JI, Ines Kaufmann, Karlsson H, Kaufmann I, Leone M, Li M, Liblau RS, Maggio M, Manfred Thiel, Marchand F, Marx C, McEwen BS, Milosevic DB, Okada M, Pamuk ON, Peter Richter, Powell JM, Radstake TRDJ, Sacerdote P, Sanders VM, Sarzi-Puttini P, Schinkel C, Schwartzman RJ, Sgoutas-Emch SA, Smart JM, Smyth LJ, Stanton-Hicks M, Stefanski V, Stoll C, Tarcic N, Tournoy KG, Tournoy KG, Tsatsoulis A, Van de Vusse AC, Van Houdenhove B, Van Houdenhove B, Vidovic A, Volker Huge, Walker EA, Weisaeth L, Woiciechowsky C, Yunus MB   +60 more
core   +1 more source

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Brucker, Cosima, Downing, James E. G., Head, Gail M., Kendall, Marion D., Mentlein, Rolf   +4 more
core   +1 more source

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Auernhammer, Christoph J., Cengic, N., Dorn, F., Engelhardt, D., Isele, N. B., Kopp, F. B., Senaldi, G., Spottl, G., Vlotides, G., Weber, M. M.   +9 more
core   +1 more source

ICAM G241A polymorphism and soluble ICAM-1 serum levels: Evidence for an active immune process in schizophrenia [PDF]

, 2005
Objectives: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism ( SNP) of the ICAM-1 gene was described at position 241.
Ackenheil, Manfred, Kronig, H., Möller, Hans-Jürgen, Müller, Norbert, Riedel, M., Schwarz, Markus J., Strassnig, M.   +6 more
core   +1 more source

Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS [PDF]

, 1998
The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the ...
Ackenheil, Manfred, Hampel, Harald, Johnson, Judith P., Kirsch, Kathrin H., Körschenhausen, Dirk, Müller, Norbert, Penning, Randolph, Schwarz, Markus J.   +7 more
core   +1 more source

Age-Related Variation in Sympathetic Nerve Distribution in the Human Spleen

Frontiers in Neuroscience, 2021
Introduction: The cholinergic anti-inflammatory pathway (CAIP) has been proposed as an efferent neural pathway dampening the systemic inflammatory response via the spleen.
Cindy G. J. Cleypool, David J. Brinkman, David J. Brinkman, Claire Mackaaij, Peter G. J. Nikkels, Martijn A. Nolte, Misha D. Luyer, Wouter J. de Jonge, Wouter J. de Jonge, Ronald L. A. W. Bleys   +9 more
doaj   +1 more source