Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19? [PDF]
Bioelectron Med, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the origin of the worldwide COVID-19 pandemic, is characterized by a dramatic cytokine storm in some critical patients with COVID-19.
Bonaz B, Sinniger V, Pellissier S.
europepmc +2 more sources
Neuroinflammation in the medullary visceral zone exert a powerful impaction on the systemic inflammation in sepsis through cholinergic anti-inflammatory pathway. [PDF]
Sci RepTo investigate whether sepsis-induced neuroinflammation of medulla visceral zone (MVZ) predominates the systemic inflammation through cholinergic anti-inflammatory pathway (CAP), and to explore the effect of central anti-inflammation on systemic ...
Liu X, Zhang C, Li H.
europepmc +2 more sources
Electroacupuncture Ameliorates Acute Pancreatitis: A Role for the Vagus Nerve-Mediated Cholinergic Anti-Inflammatory Pathway. [PDF]
Front Mol Biosci, 2021 Organ failure resulting from excessive inflammation is the leading cause of death in the early phase of acute pancreatitis (AP). The autonomic nervous system was reported to be involved in AP, and the vagus nerve could exert anti-inflammatory effects ...
Zhang L +9 more
europepmc +2 more sources
Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells. [PDF]
Sci Rep, 2022 Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Several studies have demonstrated that α7 nicotinic acetylcholine receptors (α7nAChRs) exert anti-inflammatory effects on immune cells and nicotine suppress UC onset and relapse ...
Kanauchi Y +6 more
europepmc +2 more sources
Cholinergic anti-inflammatory pathway confers protective effects in septic shock rats
STEMedicineBackground: Septic shock can lead to multiple organ dysfunction. The cholinergic anti-inflammatory pathway is known to prevent organ damage from infection by modulating the inflammatory response.
Yuchao Shen, Ying Cui
doaj +2 more sources
Targeting the cholinergic anti-inflammatory pathway for type 2 diabetes prevention: A retrospective cohort study. [PDF]
Diabetes Obes MetabChronic inflammation is a key factor in type 2 diabetes mellitus (T2DM) development. The cholinergic anti‐inflammatory pathway (CAP) reduces inflammation by activating α7 nicotinic acetylcholine receptors (α7nAChRs) on macrophages, suppressing ...
Magagnoli J +4 more
europepmc +2 more sources
The cholinergic anti-inflammatory pathway in chronic kidney disease-review and vagus nerve stimulation clinical pilot study. [PDF]
Nephrol Dial Transplant, 2020 Inflammation and autonomic dysfunction are common findings in chronic and end-stage kidney disease and contribute to a markedly increased risk of mortality in this patient population.
Hilderman M, Bruchfeld A.
europepmc +2 more sources
Street RABV Induces the Cholinergic Anti-inflammatory Pathway in Human Monocyte-Derived Macrophages by Binding to nAChr α7. [PDF]
Front Immunol, 2021 Rabies virus (RABV) is able to reach the central nervous system (CNS) without triggering a strong immune response, using multiple mechanisms to evade and suppress the host immune system.
Embregts CWE +6 more
europepmc +2 more sources
Neuro-immune interactions via the cholinergic anti-inflammatory pathway [PDF]
Life Sciences, 2007 The overproduction of TNF and other cytokines is associated with the pathophysiology of numerous diseases. Controlling cytokine synthesis and release is critical for preventing unrestrained inflammation and maintaining health. Recent studies identified an efferent vagus nerve-based mechanism termed "the cholinergic anti-inflammatory pathway" that ...
Margot Gallowitsch-Puerta +1 more
exaly +3 more sources
The cholinergic anti-inflammatory pathway delays TLR-induced skin allograft rejection in mice: cholinergic pathway modulates alloreactivity. [PDF]
PLoS ONE, 2013 Activation of innate immunity through Toll-like receptors (TLR) can abrogate transplantation tolerance by revealing hidden T cell alloreactivity. Separately, the cholinergic anti-inflammatory pathway has the capacity to dampen macrophage activation and ...
Claude Sadis +12 more
doaj +2 more sources