Results 31 to 40 of about 3,652,668 (207)

Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation

Frontiers in Cellular Neuroscience, 2020
Aging is a complex biological process that increases the risk of age-related cognitive degenerative diseases such as dementia, including Alzheimer’s disease (AD), Lewy Body Dementia (LBD), and mild cognitive impairment (MCI).
Rashmi Gamage, Ingrid Wagnon, Ilaria Rossetti, Ryan Childs, Garry Niedermayer, Rose Chesworth, Erika Gyengesi   +6 more
doaj   +1 more source

The Cholinergic Anti-Inflammatory Pathway as a Conceptual Framework to Treat Inflammation-Mediated Renal Injury

Kidney & Blood Pressure Research, 2019
Background: The cholinergic anti-inflammatory pathway, positioned at the interface of the nervous and immune systems, is the efferent limb of the “inflammatory reflex” which mainly signals through the vagus nerve.
Jonas Jarczyk, Benito A. Yard, Simone Hoeger   +2 more
doaj   +1 more source

The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation [PDF]

Molecular Medicine, 2003
This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory
Valentin A, Pavlov, Hong, Wang, Christopher J, Czura, Steven G, Friedman, Kevin J, Tracey   +4 more
openaire   +2 more sources

The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells

Frontiers in Immunology, 2017
Degeneration of central cholinergic neurons impairs memory, and enhancement of cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti-inflammatory, and neuroinflammation is increasingly linked to adverse memory, especially ...
Sara V. Maurer, Christina L. Williams
doaj   +1 more source

New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength

Frontiers in Pharmacology, 2023
Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic ...
Shangkun Si, Xiaohu Zhao, Fan Su, Hongxiu Lu, Dongbin Zhang, Li Sun, Fulei Wang, Li Xu   +7 more
doaj   +1 more source

RETRACTED ARTICLE: nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse

Scientific Reports, 2021
An evaluation of the APPswe/PS1dE9 transgenic AD mouse, presenting with the toxic Aβ1-42 deposition found in human AD, allowed us to characterize time-dependent changes in inflammatory and cholinergic markers present in AD.
Chiara D’Angelo, Erica Costantini, Nieves Salvador, Michele Marchioni, Marta Di Nicola, Nigel H. Greig, Marcella Reale   +6 more
doaj   +1 more source

Systemic Administration of α7-Nicotinic Acetylcholine Receptor Ligands Does Not Improve Renal Injury or Behavior in Mice With Advanced Systemic Lupus Erythematosus

Frontiers in Medicine, 2021
There is a critical need for safe treatment options to control inflammation in patients with systemic lupus erythematosus (SLE) since the inflammation contributes to morbidity and mortality in advanced disease.
Jessica Y. Morales, Cassandra M. Young-Stubbs, Caroline G. Shimoura, William R. Kem, Victor V. Uteshev, Keisa W. Mathis   +5 more
doaj   +1 more source

Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis [PDF]

Pharmacological Research, 2017
Sepsis is one of the main causes of mortality in hospitalized patients. Despite the recent technical advances and the development of novel generation of antibiotics, severe sepsis remains a major clinical and scientific challenge in modern medicine. Unsuccessful efforts have been dedicated to the search of therapeutic options to treat the deleterious ...
Alexandre, Kanashiro, Fabiane, Sônego, Raphael G, Ferreira, Fernanda V S, Castanheira, Caio A, Leite, Vanessa F, Borges, Daniele C, Nascimento, David F, Cólon, José Carlos, Alves-Filho, Luis, Ulloa, Fernando Q, Cunha   +10 more
openaire   +2 more sources

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation

Neurobiology of Disease, 2009
Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRα7) by nicotine or acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation.
Eva-Maria Nicolussi, Sigismund Huck, Hans Lassmann, Monika Bradl   +3 more
doaj   +1 more source

Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway [PDF]

EBioMedicine, 2019
Fabiany da C Gonçalves, Fernanda Visioli, Natalia Schneider Nunes   +2 more
exaly   +2 more sources