Results 11 to 20 of about 126,705 (239)

Modulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives [PDF]

Biochemical Pharmacology, 2021
The cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune and inflammatory responses under normal and challenged conditions. Over the past two decades, peripheral and central circuits of CAP have been shown to be critically involved in dampening the inflammatory reaction in a wide array of inflammatory disorders ...
Abdalla M Wedn, Hany M El-Bassossy, Ali H Eid   +2 more
exaly   +6 more sources

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. [PDF]

J Neuroinflammation, 2023
Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems.
Liu H, Zhang X, Shi P, Yuan J, Jia Q, Pi C, Chen T, Xiong L, Chen J, Tang J, Yue R, Liu Z, Shen H, Zuo Y, Wei Y, Zhao L.   +15 more
europepmc   +3 more sources

The cholinergic anti-inflammatory pathway: A critical review

Autonomic Neuroscience, 2014
From a critical review of the evidence on the cholinergic anti-inflammatory pathway and its mode of action, the following conclusions were reached. (1) Both local and systemic inflammation may be suppressed by electrical stimulation of the peripheral cut end of either vagus.
MARTELLI, DAVIDE, Mckinley, M. J., Mcallen, R. M.   +2 more
semanticscholar   +7 more sources

The molecular components of the anti-inflammatory cholinergic pathway are extrasplenic.

PLoS ONE
The anti-inflammatory cholinergic pathway describes the interaction between cholinergic vagal nerves and splenic immune cells, yet the exact mechanisms underlying the anti-inflammatory cholinergic pathway remain disputed.
Warda Merchant, Steven Wyler, Bandy Chen, Laurent Gautron   +3 more
doaj   +6 more sources

The cholinergic anti-inflammatory pathway revisited. [PDF]

Neurogastroenterol Motil, 2018
AbstractInflammatory bowel disease negatively affects the quality of life of millions of patients around the world. Although the precise etiology of the disease remains elusive, aberrant immune system activation is an underlying cause. As such, therapies that selectively inhibit immune cell activation without broad immunosuppression are desired ...
Murray K, Reardon C.
europepmc   +7 more sources

Alteration of Cholinergic Anti‐Inflammatory Pathway in Rat With Ischemic Cardiomyopathy–Modified Electrophysiological Function of Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWith chronic ischemia after myocardial infarction, the resulting scar tissue result in electrical and structural remodeling vulnerable to an arrhythmogenic substrate.
Shu‐Jie Wu, Yue‐Chun Li, Zhe‐Wei Shi, Zhong‐Hao Lin, Zhi‐Heng Rao, Si‐Chao Tai, Mao‐Ping Chu, Lei Li, Jia‐Feng Lin   +8 more
doaj   +4 more sources

Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats. [PDF]

J Neuroimmune Pharmacol, 2022
Infections and perioperative stress can lead to neuroinflammation, which in turn is linked to cognitive impairments such as postoperative delirium or postoperative cognitive dysfunctions.
Kho W, von Haefen C, Paeschke N, Nasser F, Endesfelder S, Sifringer M, González-López A, Lanzke N, Spies CD.   +8 more
europepmc   +4 more sources

Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway. [PDF]

EBioMedicine, 2019
Background Ulcerative Colitis (UC) is an Inflammatory Bowel Disease (IBD) characterized by uncontrolled immune response, diarrhoea, weight loss and bloody stools, where sustained remission is not currently achievable.
Nunes NS, Chandran P, Sundby M, Visioli F, da Costa Gonçalves F, Burks SR, Paz AH, Frank JA.   +7 more
europepmc   +3 more sources

Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway. [PDF]

Signal Transduct Target Ther, 2022
Mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of acute respiratory distress syndrome (ARDS). However, there is significant heterogeneity in their therapeutic efficacy, largely owing to the incomplete ...
Zhang X, Wei X, Deng Y, Yuan X, Shi J, Huang W, Huang J, Chen X, Zheng S, Chen J, Chen K, Xu R, Wang H, Li W, Li S, Yi H, Xiang AP.   +16 more
europepmc   +2 more sources

Activation of Cholinergic Anti-Inflammatory Pathway Ameliorates Cerebral and Cardiac Dysfunction After Intracerebral Hemorrhage Through Autophagy. [PDF]

Front Immunol, 2022
Background Intracerebral hemorrhage (ICH) is the devastating subtype of stroke with cardiovascular complications, resulting in high rates of mortality and morbidity with the release of inflammatory factors.
Su Y, Zhang W, Zhang R, Yuan Q, Wu R, Liu X, Wuri J, Li R, Yan T.   +8 more
europepmc   +2 more sources