The molecular components of the anti-inflammatory cholinergic pathway are extrasplenic.
PLoS ONEThe anti-inflammatory cholinergic pathway describes the interaction between cholinergic vagal nerves and splenic immune cells, yet the exact mechanisms underlying the anti-inflammatory cholinergic pathway remain disputed.
Warda Merchant +3 more
doaj +6 more sources
Evidence of upregulation of the cholinergic anti-inflammatory pathway in late-life depression [PDF]
Journal of Affective Disorders, 2021 Background Decreased cholinergic tone associated with increased proinflammatory cytokines has been observed in several human diseases associated with low-grade inflammation.
Chelsea Reichert +2 more
exaly +7 more sources
RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation [PDF]
International Immunopharmacology, 2020 Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels having many functions including inflammation control, as part of the cholinergic anti-inflammatory pathway. Genome wide association studies implicated RIC3, a chaperone of nAChRs, in multiple sclerosis (MS), a neuroinflammatory disease.
Adi Vaknin-Dembinsky +2 more
exaly +4 more sources
The intestinal cholinergic anti‐inflammatory pathway [PDF]
The Journal of Physiology, 2016 AbstractThe main task of the immune system is to distinguish and respond accordingly to ‘danger’ or ‘non‐danger’ signals. This is of critical importance in the gastrointestinal tract in which immune cells are constantly in contact with food antigens, symbiotic microflora and potential pathogens.
Gera, Goverse +2 more
openaire +3 more sources
Melanocortins and the Cholinergic Anti-Inflammatory Pathway [PDF]
, 2010 Experimental evidence indicates that small concentrations of inflammatory molecules produced by damaged tissues activate afferent signals through ascending vagus nerve fibers, that act as the sensory arm of an "inflammatory reflex". The subsequent activation of vagal efferent fibers, which represent the motor arm of the inflammatory reflex, rapidly ...
GIULIANI, Daniela +5 more
openaire +5 more sources
The cholinergic anti-inflammatory pathway revisited. [PDF]
Neurogastroenterol Motil, 2018 AbstractInflammatory bowel disease negatively affects the quality of life of millions of patients around the world. Although the precise etiology of the disease remains elusive, aberrant immune system activation is an underlying cause. As such, therapies that selectively inhibit immune cell activation without broad immunosuppression are desired ...
Murray K, Reardon C.
europepmc +8 more sources
The cholinergic anti-inflammatory pathway: A critical review [PDF]
Autonomic Neuroscience, 2014 From a critical review of the evidence on the cholinergic anti-inflammatory pathway and its mode of action, the following conclusions were reached. (1) Both local and systemic inflammation may be suppressed by electrical stimulation of the peripheral cut end of either vagus.
MARTELLI, DAVIDE +2 more
openaire +5 more sources
Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis. [PDF]
PLoS ONE, 2014 The inflammatory reflex is a physiological mechanism through which the nervous system maintains immunologic homeostasis by modulating innate and adaptive immunity.
Yaakov A Levine +7 more
doaj +2 more sources
Cholinergic anti-inflammatory pathway confers protective effects in septic shock rats
STEMedicineBackground: Septic shock can lead to multiple organ dysfunction. The cholinergic anti-inflammatory pathway is known to prevent organ damage from infection by modulating the inflammatory response.
Yuchao Shen, Ying Cui
doaj +2 more sources
The cholinergic anti-inflammatory pathway delays TLR-induced skin allograft rejection in mice: cholinergic pathway modulates alloreactivity. [PDF]
PLoS ONE, 2013 Activation of innate immunity through Toll-like receptors (TLR) can abrogate transplantation tolerance by revealing hidden T cell alloreactivity. Separately, the cholinergic anti-inflammatory pathway has the capacity to dampen macrophage activation and ...
Claude Sadis +12 more
doaj +2 more sources