Cholinergic Anti-inflammatory Pathway Attenuates Acute Liver Failure Through Inhibiting MAdCAM1/α4β7-mediated Gut-derived Proinflammatory Lymphocytes Accumulation. [PDF]
Cell Mol Gastroenterol Hepatol, 2023 Background & Aims The function of cholinergic anti-inflammatory pathway (CAP) in acute liver failure (ALF) with inflammatory storm remains indefinite. The liver-gut axis has been proved to be crucial for liver homeostasis.
Fu S +13 more
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The intestinal cholinergic anti‐inflammatory pathway [PDF]
The Journal of Physiology, 2016 AbstractThe main task of the immune system is to distinguish and respond accordingly to ‘danger’ or ‘non‐danger’ signals. This is of critical importance in the gastrointestinal tract in which immune cells are constantly in contact with food antigens, symbiotic microflora and potential pathogens.
Gera, Goverse +2 more
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Melanocortins and the Cholinergic Anti-Inflammatory Pathway [PDF]
, 2010 Experimental evidence indicates that small concentrations of inflammatory molecules produced by damaged tissues activate afferent signals through ascending vagus nerve fibers, that act as the sensory arm of an "inflammatory reflex". The subsequent activation of vagal efferent fibers, which represent the motor arm of the inflammatory reflex, rapidly ...
GIULIANI, Daniela +5 more
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Pyridostigmine bromide elicits progressive and chronic impairments in the cholinergic anti-inflammatory pathway in the prefrontal cortex and hippocampus of male rats [PDF]
Neurobiology of Stress, 2022 Gulf War Illness (GWI) is a multi-symptom illness that continues to affect over 250,000 American Gulf War veterans. The causes of GWI remain equivocal; however, prophylactic use of the acetylcholinesterase inhibitor pyridostigmine bromide (PB), and the ...
H.E. Burzynski +8 more
doaj +2 more sources
The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation [PDF]
Molecular Medicine, 2003 This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory
Valentin A, Pavlov +4 more
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Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis. [PDF]
PLoS ONE, 2014 The inflammatory reflex is a physiological mechanism through which the nervous system maintains immunologic homeostasis by modulating innate and adaptive immunity.
Yaakov A Levine +7 more
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The potential for traditional Chinese therapy in treating sleep disorders caused by COVID-19 through the cholinergic anti-inflammatory pathway [PDF]
Frontiers in Pharmacology, 2022 Since the outbreak of Coronavirus disease (COVID-19) in 2019, it has spread rapidly across the globe. Sleep disorders caused by COVID-19 have become a major concern for COVID-19 patients and recovered patients.
Xiaoxia Xie +14 more
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Non-canonical cholinergic anti-inflammatory pathway in IBD. [PDF]
Nat Rev Gastroenterol Hepatol, 2020 Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for ...
de Araujo A, de Lartigue G.
europepmc +4 more sources
Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19. [PDF]
Front Immunol, 2020 The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy.
Qin Z, Xiang K, Su DF, Sun Y, Liu X.
europepmc +2 more sources
Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3. [PDF]
Cell Death Discov, 2021 The cholinergic anti-inflammatory pathway (CAIP) is important for antagonizing inflammation and treating several diseases, including acute respiratory distress syndrome (ARDS), and is related to vagus nerve integrity.
Li S, Qi D, Li JN, Deng XY, Wang DX.
europepmc +2 more sources