Results 21 to 30 of about 3,652,668 (207)

Activation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Postoperative Ileus in Mice

Gastroenterology, 2007
We previously showed that intestinal inflammation is reduced by electrical stimulation of the efferent vagus nerve, which prevents postoperative ileus in mice. We propose that this cholinergic anti-inflammatory pathway is mediated via alpha7 nicotinic acetylcholine receptors expressed on macrophages.
The, F, Boeckxstaens, G, Snoek, SA, Cash, J, Bennink, R, Larosa, G, van den Wijngaard, R, Greaves, D, de Jonge, W   +8 more
core   +5 more sources

The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis

Nature Reviews Rheumatology, 2009
The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred to as the 'cholinergic anti-inflammatory pathway'. ACh interacts with members of the nicotinic acetylcholine receptor (nAChR) family, in particular with the alpha7 subunit (alpha7nAChR), which is expressed not only by neurons ...
van Maanen, Marjolein A., Vervoordeldonk, Margriet J., Tak, Paul P.   +2 more
openaire   +3 more sources

Research Progress in Ultrasonic Regulation of Cholinergic Anti-inflammatory Pathwa [PDF]

Advanced Ultrasound in Diagnosis and Therapy, 2022
The cholinergic anti-inflammatory pathway is a neuro-immune regulatory pathway that mediates anti-inflammatory effects based on the vagus nerve, acetylcholine and α7 nicotinic acetylcholine receptors.
Wuqi Zhou, MD, Yishu Song, MD, Rui Wang, MD, Qiaofeng Jin, MD, Mingxing Xie, PhD, Li Zhang, PhD
doaj   +1 more source

Non-canonical cholinergic anti-inflammatory pathway in IBD. [PDF]

Nat Rev Gastroenterol Hepatol, 2020
Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for ...
de Araujo A, de Lartigue G.
europepmc   +4 more sources

Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats. [PDF]

J Neuroimmune Pharmacol, 2022
: Infections and perioperative stress can lead to neuroinflammation, which in turn is linked to cognitive impairments such as postoperative delirium or postoperative cognitive dysfunctions.
Kho W, von Haefen C, Paeschke N, Nasser F, Endesfelder S, Sifringer M, González-López A, Lanzke N, Spies CD.   +8 more
europepmc   +2 more sources

Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis

Frontiers in Immunology, 2023
IntroductionInflammation is an inherently self-amplifying process, resulting in progressive tissue damage when unresolved. A brake on this positive feedback system is provided by the nervous system which has evolved to detect inflammatory signals and ...
Dane A. Thompson, Dane A. Thompson, Dane A. Thompson, Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sandeep Nadella, Lopa Mishra, Lopa Mishra, Lopa Mishra, Lopa Mishra, David A. Tuveson, Valentin A. Pavlov, Valentin A. Pavlov, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Kevin J. Tracey, Kevin J. Tracey, Sangeeta S. Chavan, Sangeeta S. Chavan, Sangeeta S. Chavan   +21 more
doaj   +1 more source

Cholinergic Modulation of the Immune System in Neuroinflammatory Diseases

Diseases, 2021
Frequent diseases of the CNS, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and psychiatric disorders (e.g., schizophrenia), elicit a neuroinflammatory response that contributes to the neurodegenerative disease process itself. The
Marcella Reale, Erica Costantini
doaj   +1 more source

Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease

Journal of Neuroinflammation, 2022
Background Alzheimer's disease (AD) is the most common neurodegenerative disease and its pathogenesis is still unclear. There is dysbiosis of gut microbiota in AD patients.
Xiao-hang Qian, Xiao-li Liu, Guang Chen, Sheng-di Chen, Hui-dong Tang   +4 more
doaj   +1 more source

Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis. [PDF]

PLoS ONE, 2014
Activation of the cholinergic anti-inflammatory pathway, which relies on the α7nAchR (alpha 7 nicotinic acetylcholine receptor), has been shown to decrease proinflammatory cytokines.
Zheng Cheng, Ge Li-Sha, Zhao Jing-Lin, Zhang Wen-Wu, Chen Xue-Si, Chen Xing-Xing, Li Yue-Chun   +6 more
doaj   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source