Results 81 to 90 of about 3,652,668 (207)

Cholinergic anti‐inflammatory pathway in the non‐obese diabetic mouse model

Oral Diseases, 2015
ObjectiveActivation of the cholinergic anti‐inflammatory pathway (CAP) has been shown to reduce inflammation in animal models, while abrogation of the pathway increases inflammation. We investigated whether modulation of CAP influences inflammation in the non‐obese diabetic (NOD) mouse model for Sjögren's syndrome and type 1 diabetes.MethodsThe alpha‐7
Koopman, F. A., Vosters, J. L., Roescher, N., Broekstra, N., Tak, P. P., Vervoordeldonk, M. J.   +5 more
openaire   +3 more sources

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Vagus nerve stimulation alleviates alveolar bone loss and inflammation in ligature-induced periodontitis rat model [PDF]

Journal of Applied Oral Science
Objective Vagus nerve stimulation (VNS) can inhibit inflammation in various diseases by activating the cholinergic anti-inflammatory pathway. However, whether VNS could attenuate periodontitis by activating α7-nicotinic acetylcholine receptor (α7-nAChR)
Honghui XIE, Ping HUANG, Aihong TAN, Zhijian SU, Ying FU   +4 more
doaj   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases [PDF]

, 2009
The cholinergic anti-inflammatory pathway (CAP) is a neurophysiological mechanism that regulates the immune system. The CAP inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in organs of the reticuloendothelial system ...
YAO, Yong-ming, ZHOU, Rong-bin, WANG, Da-wei   +2 more
core   +1 more source

Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

Acta Pharmaceutica Sinica B, 2020
Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7 nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function in inflammatory responses.
Etta Y.L. Liu, Yingjie Xia, Xiangpeng Kong, Maggie S.S. Guo, Anna X.D. Yu, Brody Z.Y. Zheng, Shinghung Mak, Miranda L. Xu, Karl W.K. Tsim   +8 more
doaj   +1 more source

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4/Myd88/MAPK Pathway Inhibition

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits.
Lijing Du, Shikai Yan, Xiaopeng Ren, Syed Shams ul Hassan, Yuanfang Sun, Yu Gan, Xue Xiao, Shasha Li, Huizi Jin   +8 more
wiley   +1 more source

Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway : a new therapeutic perspective in aging-related disorders

, 2019
Neuroinflammation and cholinergic dysfunction, leading to cognitive impairment, are hallmarks of aging and neurodegenerative disorders, including Alzheimer’s disease (AD).
Di Lascio S., Benfante R., Fornasari D., Cardani S.   +3 more
core   +1 more source

Electroacupuncturing At Zusanli Point (St36) Attenuates Pro-Inflammatory Cytokine Release And Organ Dysfunction By Activating Cholinergic Anti-Inflammatory Pathway In Rat With Endotoxin Challenge [PDF]

, 2014
Background: It is considered that the pathogenesis is closely related to an excessive production of pro-inflammatory cytokines caused by bacterial toxins and an imbalance between pro-inflammatory and anti-inflammatory mediatorsMaterials and Methods: This
Song, Q, Song, Qi, Lv, Yi, Wang, H, Wang, Haibin, Hu, Sen, Sheng, W, Shi, X, Shi, Xian, Sheng, Ziyong, Sheng, Z, Hu, S, Lv, Y, Sheng, Wei   +13 more
core   +1 more source