Results 81 to 90 of about 1,282,638 (192)

Comprehensive view of macrophage autophagy and its application in cardiovascular diseases

Cell Proliferation, Volume 57, Issue 1, January 2024.
This review systematically describes the role of autophagy in macrophage functions, highlighting the existing evidence in the regulation of inflammation, cell death, metabolism, phagocytosis, and so forth. Meanwhile, we summarize the latest progress of therapeutics targeting macrophage autophagy in cardiovascular diseases, hoping to provide novel ...
Wanqian Pan, Jun Zhang, Lei Zhang, Yue Zhang, Yiyi Song, Lianhua Han, Mingyue Tan, Yunfei Yin, Tianke Yang, Tingbo Jiang, Hongxia Li   +10 more
wiley   +1 more source

Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]

, 2006
It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Dolga, A.,, Eisel, U.L.M.,, Dolga, Amalia, Dere, E., I. Pieri, L. Marchetti, Dere, E.,, Pieri, I., Marchetti, L., De Souza Silva, M. A., Huston, J. P., Marchetti, L.,, A. Dolga, J. P. Huston, Dolga, Amalia; id_orcid, U. L. M. Eisel, Huston, J.P.,, Pieri, I.,, Eisel, U. L. M., Souza Silva, M.A. De,, E. Dere, M. A. De Souza Silva, Eisel, U. L. M.; id_orcid   +22 more
core   +1 more source

Synthese, Assemblierung und intrazellulärer Transport von Mitgliedern der cys-loop- und P2X-Familie liganden-gesteuerter Ionenkanäle [PDF]

, 2006
The results presented here strongly indicate that ubiquitination of the recombinant human alpha1 GlyR at the plasma membrane of Xenopus oocytes is involved in receptor internalisation and degradation.
Sadtler, Sven
core  

Quantification of Proliferating and Mitotically Active Retinal Cells in Mice by Flow Cytometry

Bio-Protocol
Adult mammals lack the ability to regenerate retinal neurons after injury. However, in previous studies from this lab, topical application of the selective alpha7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, has been associated with an ...
Hope Vanzo-Sparks, Sarah Webster, Mark Webster, Cindy Linn   +3 more
doaj   +1 more source

Role of Nicotinic Acetylcholine Receptor α3 and α7 Subunits in Detrusor Overactivity Induced by Partial Bladder Outlet Obstruction in Rats [PDF]

International Neurourology Journal, 2015
Purpose: To investigate the role of α3 and α7 nicotinic acetylcholine receptor subunits (nAChRs) in the bladder, using a rat model with detrusor overactivity induced by partial bladder outlet obstruction (BOO).
Hyo Sin Kim, Wang Jin Park, Eun Young Park, Jun Sung Koh, Tae-Kon Hwang, Joon Chul Kim   +5 more
doaj   +1 more source

Potentials of Mean Force for Acetylcholine Unbinding from the Alpha7 Nicotinic Acetylcholine Receptor Ligand-Binding Domain

, 2016
The nicotinic acetylcholine receptor is a prototype ligand-gated ion channel that mediates signal transduction in the neuromuscular junctions and other cholinergic synapses.
J. Andrew McCammon (12411), Justin Gullingsrud (402152), Deqiang Zhang (12410)   +2 more
core   +2 more sources

Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors [PDF]

Neuropharmacology, 2015
The α7nAChR agonist, PNU-282987, has previously been shown to have a neuroprotective effect against loss of retinal ganglion cells (RGCs) in an in vivo glaucoma model when the agent was injected into the vitreous chamber of adult Long Evans rat eyes. Here, we characterized the neuroprotective effect of PNU-282987 at the nerve fiber and retinal ganglion
David Mata, David M. Linn, Cindy L. Linn
openaire   +2 more sources

Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. [PDF]

PLoS ONE, 2012
Kynurenic acid (KYNA), a classical ionotropic glutamate receptor antagonist is also purported to block the α7-subtype nicotinic acetylcholine receptor (α7* nAChR).
Peter Dobelis, Kevin J Staley, Donald C Cooper   +2 more
doaj   +1 more source

Anion Conducting States of Excitatory Amino Acid Transporters [PDF]

, 2013
Excitatory amino acid transporters (EAATs) are secondary active, electrogenic transporters which translocate L-glutamate (glu) against its concentration gradient using the co-transport of 3 Na+, 1 H+, and the counter-transport of 1 K+ ion.
Divito, Christopher B.
core  

Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen [PDF]

, 2002
The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus.
Wilcox, Nick, Matthews, I, Stott, David, Ledwidge, S, Vincent, Angela, Willcox, N, Beeson, David, Vincent, A, Sims, G, Stott, D, Matthews, Ian, Sims, Gary, Ledwidge, Serena, Beeson, D   +13 more
core   +1 more source