Results 81 to 90 of about 2,877 (196)

Comprehensive view of macrophage autophagy and its application in cardiovascular diseases

Cell Proliferation, Volume 57, Issue 1, January 2024.
This review systematically describes the role of autophagy in macrophage functions, highlighting the existing evidence in the regulation of inflammation, cell death, metabolism, phagocytosis, and so forth. Meanwhile, we summarize the latest progress of therapeutics targeting macrophage autophagy in cardiovascular diseases, hoping to provide novel ...
Wanqian Pan, Jun Zhang, Lei Zhang, Yue Zhang, Yiyi Song, Lianhua Han, Mingyue Tan, Yunfei Yin, Tianke Yang, Tingbo Jiang, Hongxia Li   +10 more
wiley   +1 more source

Nicotine strongly activates dendritic cell-mediated adaptive immunity - potential role for progression of atherosclerotic lesions

, 2003
Background - Antigen-presenting cells (APCs) such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation in the course of adaptive immunity.
Dimmeler, S, Heeschen, C, Andreas M. Zeiher, Alexandra Aicher, Cooke, JP, Mariette Mohaupt, Aicher, A, Aicher, A., Christopher Heeschen, Stefanie Dimmeler, John P. Cooke, Zeiher, A.M., Heeschen, C., Dimmeler, S., Mohaupt, M, Mohaupt, M., Zeiher, AM, Cooke, J.P.   +17 more
core   +1 more source

Quantification of Proliferating and Mitotically Active Retinal Cells in Mice by Flow Cytometry

Bio-Protocol
Adult mammals lack the ability to regenerate retinal neurons after injury. However, in previous studies from this lab, topical application of the selective alpha7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, has been associated with an ...
Hope Vanzo-Sparks, Sarah Webster, Mark Webster, Cindy Linn   +3 more
doaj   +1 more source

Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation

Journal of Neuroinflammation, 2010
Background A major site of initiation of inflammatory responses upon physical perturbation(s) and infection by invading organisms is the skin. Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor ...
Osborne Amber V, Gahring Lorise C, Reed Michelle, Rogers Scott W   +3 more
doaj   +1 more source

Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. [PDF]

PLoS ONE, 2012
Kynurenic acid (KYNA), a classical ionotropic glutamate receptor antagonist is also purported to block the α7-subtype nicotinic acetylcholine receptor (α7* nAChR).
Peter Dobelis, Kevin J Staley, Donald C Cooper   +2 more
doaj   +1 more source

The Spinal α7-Nicotinic Acetylcholine Receptor Contributes to the Maintenance of Cancer-Induced Bone Pain

Journal of Pain Research, 2021
Ting Yang1 1, Yaqun Zhou1 1, Wen Zhang1 1, Longqing Zhang1 1, Shuping Chen1 1, Chao Chen1 1, Feng Gao1 1, Hui Yang1 1, Anne Manyande2 2, Jie Wang3 3, Yuke Tian1 1, Xuebi Tian1 1 1Department of Anesthesiology, Tongji Hospital, Tongji Medical College ...
Yang T, Zhou Y, Zhang W, Zhang L, Chen S, Chen C, Gao F, Yang H, Manyande A, Wang J, Tian Y, Tian X   +11 more
doaj  

Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus

, 2012
Nicotine is known to enhance long-term hippocampus dependent learning and memory in both rodents and humans via its activity at nicotinic acetylcholinergic receptors (nAChRs).
Rachel L Poole, Gould, Thomas J., Michael D Adoff, Gould Thomas J., Kenney, Justin W., Thomas J Gould, Poole Rachel L., Poole, Rachel L., Logue, Sheree F., Kenney Justin W., Justin W Kenney, Sheree F Logue, Logue Sheree F., Adoff, Michael D., Adoff Michael D.   +14 more
core   +1 more source

Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.

, 2000
Two homomer-forming nicotinic acetylcholine receptor subunits with 47% identity in their amino acid sequences were employed to compare the actions of cholinergic anthelmintics and ivermectin on expressed vertebrate and nematode nicotinic receptors of ...
Sattelle, D B, Mongan, N P, Raymond, V
core   +1 more source

Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage

Mediators of Inflammation, 2010
The inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms.
Bolin Cai, Edwin A. Deitch, Luis Ulloa
doaj   +1 more source

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

, 1998
International audienceWe report that preapplication of ivermectin, in the micromolar range, strongly enhances the subsequent acetylcholine-evoked current of the neuronal chick or human alpha7 nicotinic acetylcholine receptors reconstituted in Xenopus ...
Buisson, Bruno, Bertrand, Sonia, Jean-Luc Galzi, Daniel Bertrand, Corringer, Pierre-Jean, Jean-Pierre Changeux, Changeux, Jean-Pierre, Galzi, Jean-Luc, Bruno Buisson, Bertrand, Daniel, Pierre-Jean Corringer, Krause, Ryoko, M., Ryoko M. Krause, Sonia Bertrand   +13 more
core   +1 more source