Results 61 to 70 of about 1,282,638 (192)

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Journal of Neuroinflammation, 2023
Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems.
Huiyang Liu, Xiaomei Zhang, Peng Shi, Jiyuan Yuan, Qiang Jia, Chao Pi, Tao Chen, Linjin Xiong, Jinglin Chen, Jia Tang, Ruxu Yue, Zerong Liu, Hongping Shen, Ying Zuo, Yumeng Wei, Ling Zhao   +15 more
doaj   +1 more source

Modulation of alpha7 nicotinic acetylcholine receptor by cannabidiol

, 2022
Fil: Esandi, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur.
Chrestia, Juan Facundo, Esandi, María del Carmen, Bouzat, Cecilia Beatriz   +2 more
openaire   +1 more source

Dual impact of smoking cessation and post‐cessation weight change on psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 285-295, February 2026.
Although smoking cessation generally reduced the risk of psoriasis, especially psoriasis vulgaris and palmoplantar pustulosis, post‐cessation weight gain weakened this benefit, mainly for psoriasis vulgaris. Nonetheless, cessation maintained a substantial protective effect against palmoplantar pustulosis, and long‐term advantages outweighed the adverse
Seong Rae Kim, Young‐Geun Choi, Seong Jin Jo   +2 more
wiley   +1 more source

Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
The popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Biyun Zhang, Mone Ando, Kohei Kawano, Yusaku Iwasaki, Kazuo Inoue, Kousaku Ohinata   +5 more
wiley   +1 more source

Genome‐wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD). METHODS We performed a pleiotropy genome‐wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory ...
Moonil Kang, Ting Fang Alvin Ang, Sherral A. Devine, Richard Sherva, Shubhabrata Mukherjee, Emily H. Trittschuh, Phoebe Scollard, Michael Lee, Seo‐Eun Choi, Brandon Klinedinst, Connie Nakano, Logan C. Dumitrescu, Timothy J. Hohman, Michael L. Cuccaro, Andrew J. Saykin, Walter A. Kukull, David A. Bennett, Li‐San Wang, Richard P. Mayeux, Jonathan L. Haines, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, Paul K. Crane, Rhoda Au, Kathryn L. Lunetta, Jesse Mez, Lindsay A. Farrer   +26 more
wiley   +1 more source

Ly6h Regulates Trafficking of Alpha7 Nicotinic Acetylcholine Receptors and Nicotine-Induced Potentiation of Glutamatergic Signaling [PDF]

The Journal of Neuroscience, 2015
α7 nAChRs are expressed widely throughout the brain, where they are important for synaptic signaling, gene transcription, and plastic changes that regulate sensory processing, cognition, and neural responses to chronic nicotine exposure. However, the mechanisms by which α7 nAChRs are regulated are poorly understood.
Clare A, Puddifoot, Meilin, Wu, Rou-Jia, Sung, William J, Joiner   +3 more
openaire   +2 more sources

Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation

Advanced Science, Volume 12, Issue 2, January 13, 2025.
After implantation of the immunoregulatory scaffold into the body, infiltrated immune cells produce MMP, enabling the degradation of MMP‐responsive hydrogels. Subsequently, galactose‐modified nanoparticles are exposed and phagocytosed by macrophages, triggering their transformation into an anti‐inflammatory phenotype.
Xing Chen, Yunlong Wu, Peng Song, Liandong Feng, Ying Zhou, Jiawei Shi, Nianguo Dong, Weihua Qiao   +7 more
wiley   +1 more source

Changes in conformation and subcellular distribution of alpha(4)beta(2) nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras [PDF]

, 2002
Chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs).
Harkness, PC, Millar, NS
core  

Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology

Life
Cholinergic projections from the basal forebrain to the cortex and hippocampus play a critical role in cognitive functions, many of which rely on signaling through the alpha7 nicotinic acetylcholine receptor (α7nAChR).
Kerry Rennie
doaj   +1 more source

A Review of the Role of Paraprobiotics in the Formulation of High‐Protein Ice Cream as an Advanced Functional Food

International Journal of Food Science, Volume 2025, Issue 1, 2025.
Paraprobiotics are nonvital bacteria that have health benefits. Recently, they have been incorporated into dairy products as supplements to probiotics. The advantages of using paraprobiotics mainly include superior resistance to processing conditions, extended shelf‐life, and safer consumption by people with weaker immune systems.
Seyed Ali Issazadeh, Samaneh Hatami, Ivan Salmerón   +2 more
wiley   +1 more source