Results 61 to 70 of about 2,877 (196)

Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]

, 2006
It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Dolga, A.,, Eisel, U.L.M.,, Dolga, Amalia, Dere, E., I. Pieri, L. Marchetti, Dere, E.,, Pieri, I., Marchetti, L., De Souza Silva, M. A., Huston, J. P., Marchetti, L.,, A. Dolga, J. P. Huston, Dolga, Amalia; id_orcid, U. L. M. Eisel, Huston, J.P.,, Pieri, I.,, Eisel, U. L. M., Souza Silva, M.A. De,, E. Dere, M. A. De Souza Silva, Eisel, U. L. M.; id_orcid   +22 more
core   +1 more source

Modulation of alpha7 nicotinic acetylcholine receptor by cannabidiol

, 2022
Fil: Esandi, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur.
Chrestia, Juan Facundo, Esandi, María del Carmen, Bouzat, Cecilia Beatriz   +2 more
openaire   +1 more source

Neuronal nicotinic receptors as new targets foramphetamine-induced oxidative damage and neurotoxicity

, 2011
Amphetamine derivatives such as methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are drugs widely abused in a recreational context.
Pubill Sánchez, David, Camarasa García, Jordi, Elena Escubedo, Sara Garcia-Ratés, David Pubill, Garcia Ratés, Sara, Escubedo Rafa, Elena, Jordi Camarasa   +7 more
core   +1 more source

Dual impact of smoking cessation and post‐cessation weight change on psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 285-295, February 2026.
Although smoking cessation generally reduced the risk of psoriasis, especially psoriasis vulgaris and palmoplantar pustulosis, post‐cessation weight gain weakened this benefit, mainly for psoriasis vulgaris. Nonetheless, cessation maintained a substantial protective effect against palmoplantar pustulosis, and long‐term advantages outweighed the adverse
Seong Rae Kim, Young‐Geun Choi, Seong Jin Jo   +2 more
wiley   +1 more source

Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases [PDF]

, 2005
Nicotine, a component of tobacco, is highly addictive but possesses beneficial properties such as cognitive improvements and memory maintenance. Involved in these processes is the neuronal nicotinic acetylcholine receptor (nAChR) alpha7, whose activation
Hoda, J. C., Huh, K H, Hoda, J C, Charpantier, E, Raggenbass, M, Allaman, Geraldine, Ogier, R, Raggenbass, Mario, Allaman, G, Charpantier, Eric, Fuhrer, Christian, Wiesner, A, Bertrand, Daniel, Wiesner, Andreas, Huh, K. H., Feuerbach, D, Ogier, Roch, Bertrand, D, Feuerbach, Dominik, Fuhrer, Christian; https://orcid.org/   +19 more
core   +1 more source

Characterization of a Bovine Serum Albumin‐Derived Pro‐Cognitive Peptide (bSAPP): An Orally Active Peptide Alleviates Cognitive Decline in HFD‐Fed Mice via CCK Signaling Through the Gut‐Brain Axis

The FASEB Journal, Volume 39, Issue 24, 31 December 2025.
The popularity of the Western diet has increased the prevalence of dementia in addition to aging. We found that the digest of bovine serum albumin and a peptide derived from the digest showed an oral pro‐cognitive effect in mice fed a high‐fat diet (HFD). We named the peptide bSAPP (EC50 = 0.01 mg/kg BW). The oral effect of bSAPP was modulated by CCK1R
Biyun Zhang, Mone Ando, Kohei Kawano, Yusaku Iwasaki, Kazuo Inoue, Kousaku Ohinata   +5 more
wiley   +1 more source

The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics.

, 2005
The structure of a homopentameric alpha7 nicotinic acetylcholine receptor is modelled by combining structural information from two sources: the X-ray structure of a water soluble acetylcholine binding protein from Lymnea stagnalis, and the electron ...
Sansom, MS, Tai, K, Biggin, PC, Beckstein, O, Biggin, Philip, Amiri, S   +5 more
core   +1 more source

Impaired Hippocampal Theta Oscillations in the Mice Null Alpha7 Nicotinic Acetylcholine Receptors [PDF]

CNS Neuroscience & Therapeutics, 2013
Nicotinic acetylcholine receptor (nAChR) a7 subunits are among the most ancient of vertebrate nAChR subunits and have the capacity to assemble as homomers. Naturally expressed a7-nAChRs in the central nervous system play a critical role in modulating the release of various neurotransmitters, neurite outgrowth, and even neuronal survival or death [1 ...
Yu, Jin, Quan-Xi, Su, Jian-Xin, Shen, Michael J, Marks, Jie, Wu   +4 more
openaire   +2 more sources

Genome‐wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD). METHODS We performed a pleiotropy genome‐wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory ...
Moonil Kang, Ting Fang Alvin Ang, Sherral A. Devine, Richard Sherva, Shubhabrata Mukherjee, Emily H. Trittschuh, Phoebe Scollard, Michael Lee, Seo‐Eun Choi, Brandon Klinedinst, Connie Nakano, Logan C. Dumitrescu, Timothy J. Hohman, Michael L. Cuccaro, Andrew J. Saykin, Walter A. Kukull, David A. Bennett, Li‐San Wang, Richard P. Mayeux, Jonathan L. Haines, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, Paul K. Crane, Rhoda Au, Kathryn L. Lunetta, Jesse Mez, Lindsay A. Farrer   +26 more
wiley   +1 more source

Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation

Advanced Science, Volume 12, Issue 2, January 13, 2025.
After implantation of the immunoregulatory scaffold into the body, infiltrated immune cells produce MMP, enabling the degradation of MMP‐responsive hydrogels. Subsequently, galactose‐modified nanoparticles are exposed and phagocytosed by macrophages, triggering their transformation into an anti‐inflammatory phenotype.
Xing Chen, Yunlong Wu, Peng Song, Liandong Feng, Ying Zhou, Jiawei Shi, Nianguo Dong, Weihua Qiao   +7 more
wiley   +1 more source