Results 41 to 50 of about 2,877 (196)

Heart development and regeneration—a multi‐organ effort

The FEBS Journal, Volume 290, Issue 4, Page 913-930, February 2023., 2023
Development and regeneration of the heart are processes controlled not only by intrinsic cardiac factors but also by molecular signals originating from other organs. While the former have been the focus of intense research, the importance of the latter has been recognized only more recently.
Alessandro Filosa, Suphansa Sawamiphak
wiley   +1 more source

Parental smoking, type 1 diabetes, and islet autoantibody positivity in the offspring: A systematic review and meta‐analysis

Diabetic Medicine, Volume 39, Issue 6, June 2022., 2022
Abstract Aims Our aim was to synthesize current evidence on the association between parental smoking and incidence of type 1 diabetes and islet autoantibody positivity (IA) in the offspring by conducting a systematic review and meta‐analysis. Methods We searched Medline, Embase, and Cochrane Library until January 21, 2021, for human studies with ...
Jessica Edstorp, Anna‐Maria Lampousi, Sofia Carlsson   +2 more
wiley   +1 more source

Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids [PDF]

, 2012
This dissertation primarily describes structure-function studies of the nicotinic acetylcholine receptors (nAChRs). These studies use a combination of unnatural amino acid mutagenesis and electrophysiology to determine the specific molecular interactions
Puskar, Nyssa Leigh
core   +1 more source

Allenamides Playing Domino: A Redox‐Neutral Photocatalytic Synthesis of Functionalized 2‐Aminofurans

Advanced Synthesis &Catalysis, Volume 364, Issue 2, Page 362-371, January 18, 2022., 2022
Abstract A photoredox catalytic synthesis of functionalized 2‐aminofurans is proposed starting from α‐halo carbonyl substrates and N‐allenamides. The protocol proves to be efficient and sustainable thanks to: i) the use of visible light as green energy source, ii) the redox‐neutral nature of the transformation, allowing to avoid additives and strong ...
Arianna Quintavalla, Ruben Veronesi, Laura Speziali, Ada Martinelli, Nelsi Zaccheroni, Liviana Mummolo, Marco Lombardo   +6 more
wiley   +1 more source

Alzheimer's disease drug development pipeline: 2022

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 8, Issue 1, 2022., 2022
Abstract Introduction Alzheimer's disease (AD) represents a global health crisis. Treatments are needed to prevent, delay the onset, slow the progression, improve cognition, and reduce behavioral disturbances of AD. We review the current clinical trials and drugs in development for the treatment of AD.
Jeffrey Cummings, Garam Lee, Pouyan Nahed, Mina Esmail Zadeh Nojoo Kambar, Kate Zhong, Jorge Fonseca, Kazem Taghva   +6 more
wiley   +1 more source

Proteomic Analysis of an α7 Nicotinic Acetylcholine Receptor Interactome [PDF]

Journal of Proteome Research, 2009
The alpha7 nicotinic acetylcholine receptor (nAChR) is well established as the principal high-affinity alpha-bungarotoxin-binding protein in the mammalian brain. We isolated carbachol-sensitive alpha-bungarotoxin-binding complexes from total mouse brain tissue by affinity immobilization followed by selective elution, and these proteins were ...
Joao A, Paulo, William J, Brucker, Edward, Hawrot   +2 more
openaire   +2 more sources

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source

The spinal α7-nicotinic acetylcholine receptor contributes to the maintenance of cancer-induced bone pain [PDF]

, 2021
Introduction: Cancer-induced bone pain (CIBP) is acknowledged as a multifactorial chronic pain that tortures advanced cancer patients, but existing treatment strategies for CIBP have not been satisfactory yet.
Yang, T, Zhang, W, Wang, J, Tian, Y, Manyande, Anne, Tian, X, Zhang, L, Chen, S, Chen, C, Zhou, Y, Yang, H, Gao, F   +11 more
core   +1 more source

Discovery of the Nicotinic Receptor Toxin Anabaseine in a Polystiliferan Nemertean

Toxins, 2023
Nemerteans (also called Nemertines) are a phylum of predominantly marine worms that use toxins to capture prey and to defend themselves against predators.
William R. Kem, James R. Rocca, Jodie V. Johnson, Juan Junoy   +3 more
doaj   +1 more source

Copy number variations in healthy subjects. Case study: iPSC line CSSi005-A (3544) production from an individual with variation in 15q13.3 chromosome duplicating gene CHRNA7

Stem Cell Research, 2018
CHRNA7, encoding the neuronal alpha7 nicotinic acetylcholine receptor (a7nAChR), is highly expressed in the brain, particularly in the hippocampus. It is situated in the 15q13.3 chromosome region, frequently associated with a Copy Number Variation (CNV),
Elisa Maria Turco, Ersilia Vinci, Filomena Altieri, Daniela Ferrari, Barbara Torres, Marina Goldoni, Giuseppe Lamorte, Ada Maria Tata, Gianluigi Mazzoccoli, Diana Postorivo, Matteo Della Monica, Laura Bernardini, Angelo Luigi Vescovi, Jessica Rosati   +13 more
doaj   +1 more source