Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
BMC Cardiovascular Disorders, 2012 Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular diseases. The role of the alpha7 nicotinic acetylcholine receptor (α7nAChR) in inflammation has recently been identified.
Chen Ji-Kuai +5 more
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Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease [PDF]
Biochemical Pharmacology, 2011 Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to ...
Parri, H. Rheinallt +2 more
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Stem Cell Research, 2019 The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia.
Hjalte M. Larsen +4 more
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Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia [PDF]
Neuropsychopharmacology, 2011 Individuals diagnosed with schizophrenia have an exceptionally high risk for tobacco dependence. Postmortem studies show that these individuals have significant reductions in α7 nicotinic acetylcholine receptors (nAChRs) in several brain areas. Decreased α7-mediated function might not only be linked to schizophrenia but also to increased tobacco ...
Brunzell, Darlene H, McIntosh, J Michael
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Alpha7 nicotinic acetylcholine receptor in macrophage apoptosis and efferocytosis
The FASEB Journal, 2012 The development of atherosclerotic lesions depends on an important inflammatory component mediated mostly by macrophages. Notably, apoptosis of macrophages within the lesion and efficient clearance of apoptotic cells are key factors in lesion progression.
Robert Lee, Guillermo Vazquez
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Ly6h Regulates Trafficking of Alpha7 Nicotinic Acetylcholine Receptors and Nicotine-Induced Potentiation of Glutamatergic Signaling [PDF]
The Journal of Neuroscience, 2015 α7 nAChRs are expressed widely throughout the brain, where they are important for synaptic signaling, gene transcription, and plastic changes that regulate sensory processing, cognition, and neural responses to chronic nicotine exposure. However, the mechanisms by which α7 nAChRs are regulated are poorly understood.
Clare A, Puddifoot +3 more
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Stimulating Neuroprotective and Regenerative Mechanisms in Alzheimer Disease [PDF]
, 2013 The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions.
Lilja, Anna M
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, 2016 The nicotinic acetylcholine receptor is a prototype ligand-gated ion channel that mediates signal transduction in the neuromuscular junctions and other cholinergic synapses.
J. Andrew McCammon (12411) +2 more
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The subtype-selective nicotinic acetylcholine receptor positive allosteric potentiator 2087101 differentially facilitates neurotransmission in the brain [PDF]
, 2019 Positive allosteric modulators of centrally expressed nicotinic acetylcholine receptors have therapeutic potentials in areas of cognition, motor function and reward.
de Filippi, G +5 more
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Journal of Neuroinflammation, 2023 Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems.
Huiyang Liu +15 more
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