Results 31 to 40 of about 1,282,638 (192)

Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3

Protein Science, Volume 32, Issue 9, September 2023., 2023
Abstract Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface.
Jennifer D. Noonan, Robin N. Beech
wiley   +1 more source

Hypothalamic α7 nicotinic acetylcholine receptor (α7nAChR) is downregulated by TNFα‐induced Let‐7 overexpression driven by fatty acids

The FASEB Journal, Volume 37, Issue 9, September 2023., 2023
(A) Mice acutely exposed to an obesogenic diet have higher TNFα and Let‐7a, while lower Chrna7 levels in the hypothalamus, as well as the hypothalamic neuronal cells exposed to fatty acids overload. (B) In vitro assays confirmed that Let‐7a can directly regulate Chrna7 levels. (C) When the hypothalamic neuronal cells exposed to fatty acids overload are
Laís A. P. Simino, Mayara N. Baqueiro, Carolina Panzarin, Priscilla K. F. Lopes, Mariana M. Góis, Fernando M. Simabuco, Letícia M. Ignácio‐Souza, Marciane Milanski, Michael G. Ross, Mina Desai, Adriana S. Torsoni, Marcio A. Torsoni   +11 more
wiley   +1 more source

Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. [PDF]

PLoS ONE, 2012
The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent protein (
Scott W Rogers, Lorise C Gahring
doaj   +1 more source

Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly

Molecules, 2022
The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has at least two independent and
Ralph H. Loring
doaj   +1 more source

A sequence‐based foldability score combined with AlphaFold2 predictions to disentangle the protein order/disorder continuum

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 4, Page 466-484, April 2023., 2023
Abstract Order and disorder govern protein functions, but there is a great diversity in disorder, from regions that are—and stay—fully disordered to conditional order. This diversity is still difficult to decipher even though it is encoded in the amino acid sequences.
Apolline Bruley, Tristan Bitard‐Feildel, Isabelle Callebaut, Elodie Duprat   +3 more
wiley   +1 more source

In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. [PDF]

PLoS ONE, 2010
BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Jun Toyohara, Kiichi Ishiwata, Muneyuki Sakata, Jin Wu, Shingo Nishiyama, Hideo Tsukada, Kenji Hashimoto   +6 more
doaj   +1 more source

Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders

Pharmaceutics, 2022
Accumulating data suggest that α7 nicotinic acetylcholine receptors (α7nAChRs) are an important therapeutic target for the treatment of Alzheimer’s disease (AD) and schizophrenia.
Chien-Hsing Lee, Shih-Ya Hung
doaj   +1 more source

Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks

Aging Cell, Volume 22, Issue 2, February 2023., 2023
Dietary choline deficiency throughout adulthood induces motor impairments, weight gain, impaired glucose metabolism, cardiac and liver pathology, and exacerbates Alzheimer's Disease (AD) hallmarks. If generalized to humans, these findings may help mitigate the estimated increase in the prevalence of AD and illustrates the importance of adequate dietary
Nikhil Dave, Jessica M. Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K. Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K. Winstone, Erik A. Blackwood, Christopher Glembotski, Timothy Karr, Ramon Velazquez   +15 more
wiley   +1 more source

Heart development and regeneration—a multi‐organ effort

The FEBS Journal, Volume 290, Issue 4, Page 913-930, February 2023., 2023
Development and regeneration of the heart are processes controlled not only by intrinsic cardiac factors but also by molecular signals originating from other organs. While the former have been the focus of intense research, the importance of the latter has been recognized only more recently.
Alessandro Filosa, Suphansa Sawamiphak
wiley   +1 more source

Parental smoking, type 1 diabetes, and islet autoantibody positivity in the offspring: A systematic review and meta‐analysis

Diabetic Medicine, Volume 39, Issue 6, June 2022., 2022
Abstract Aims Our aim was to synthesize current evidence on the association between parental smoking and incidence of type 1 diabetes and islet autoantibody positivity (IA) in the offspring by conducting a systematic review and meta‐analysis. Methods We searched Medline, Embase, and Cochrane Library until January 21, 2021, for human studies with ...
Jessica Edstorp, Anna‐Maria Lampousi, Sofia Carlsson   +2 more
wiley   +1 more source