Results 31 to 40 of about 2,877 (196)
Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. [PDF]
PLoS ONE, 2009 Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons.
Jun Il Kang, Elvire Vaucher
doaj +1 more source
Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. [PDF]
PLoS ONE, 2008 BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced ...
Atsuo Kawakita +6 more
doaj +1 more source
iMeta, Volume 2, Issue 4, November 2023., 2023 We obtained 72 strains of Latilactobacillus sakei from 120 fermentation and fecal samples across China. In total, 16 strains from different sources were initially screened in an in vitro Caco‐2 model. Subsequently, six strains (four exhibiting effectiveness and two exhibiting ineffectiveness) were selected for further validation in an in vivo colitis ...
Yaru Liu +9 more
wiley +1 more source
Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3
Protein Science, Volume 32, Issue 9, September 2023., 2023 Abstract Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface.
Jennifer D. Noonan, Robin N. Beech
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The FASEB Journal, Volume 37, Issue 9, September 2023., 2023 (A) Mice acutely exposed to an obesogenic diet have higher TNFα and Let‐7a, while lower Chrna7 levels in the hypothalamus, as well as the hypothalamic neuronal cells exposed to fatty acids overload. (B) In vitro assays confirmed that Let‐7a can directly regulate Chrna7 levels. (C) When the hypothalamic neuronal cells exposed to fatty acids overload are
Laís A. P. Simino +11 more
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Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 4, Page 466-484, April 2023., 2023 Abstract Order and disorder govern protein functions, but there is a great diversity in disorder, from regions that are—and stay—fully disordered to conditional order. This diversity is still difficult to decipher even though it is encoded in the amino acid sequences.
Apolline Bruley +3 more
wiley +1 more source
Speculation on How RIC-3 and Other Chaperones Facilitate α7 Nicotinic Receptor Folding and Assembly
Molecules, 2022 The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has at least two independent and
Ralph H. Loring
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In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. [PDF]
PLoS ONE, 2010 BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Jun Toyohara +6 more
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Pharmaceutics, 2022 Accumulating data suggest that α7 nicotinic acetylcholine receptors (α7nAChRs) are an important therapeutic target for the treatment of Alzheimer’s disease (AD) and schizophrenia.
Chien-Hsing Lee, Shih-Ya Hung
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Aging Cell, Volume 22, Issue 2, February 2023., 2023 Dietary choline deficiency throughout adulthood induces motor impairments, weight gain, impaired glucose metabolism, cardiac and liver pathology, and exacerbates Alzheimer's Disease (AD) hallmarks. If generalized to humans, these findings may help mitigate the estimated increase in the prevalence of AD and illustrates the importance of adequate dietary
Nikhil Dave +15 more
wiley +1 more source