Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology. [PDF]
Int J Mol Sci, 2012 Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of α7 nAChR are a wide group represented by conotoxin and bungarotoxin.
Pohanka M.
europepmc +5 more sources
18 F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation [PDF]
EJNMMI ResearchBackground The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury.
Yong-il Kim +10 more
doaj +3 more sources
Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides. [PDF]
PLoS ONE, 2009 BACKGROUND: The alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Cherie E Bond +2 more
doaj +3 more sources
GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Leprdb/db mice [PDF]
Scientific Reports, 2022 Diabetic nephropathy (DN) is a serious complicating factor in human type 2 diabetes mellitus (T2DM), and it commonly results in end-stage renal disease (ESRD) that requires kidney dialysis.
Qinghe Meng +6 more
doaj +2 more sources
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. [PDF]
PLoS ONE, 2016 The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)
Linda J Bristow +22 more
doaj +2 more sources
Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration [PDF]
Neuroscience and Biobehavioral Reviews, 2008 Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques.
Peter Davies, Luis Ulloa
exaly +3 more sources
Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. [PDF]
PLoS ONE, 2012 The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent protein (
Scott W Rogers, Lorise C Gahring
doaj +2 more sources
Nicotinic Acetylcholine Receptors Assembled from the α7 and β3 Subunits [PDF]
Journal of Biological Chemistry, 1999 Intracellular recordings were performed in voltage-clamped Xenopus oocytes upon injection with a mixture of cDNAs encoding the beta3 and mutant alpha7 (L247Talpha7) neuronal nicotinic acetylcholine receptor (nAChR) subunits. The expressed receptors maintained sensitivity to methyllycaconitine and to alpha-bungarotoxin but exhibited a functional profile
PALMA, Eleonora +4 more
openaire +5 more sources
Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: The cytotoxic properties upon treatment with nicotine have been reported in several studies, but the underlying mechanisms remain not fully defined.
Khalil Hajiasgharzadeh +8 more
doaj +2 more sources
A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain [PDF]
Proceedings of the National Academy of Sciences, 2001 We describe the construction of a soluble protein carrying the N-terminal extracellular domain (ECD) of the α7 subunit of the nicotinic acetylcholine receptor. The approach was to fuse the α7 ECD at the C and N termini of several monomeric and pentameric soluble carrier proteins and to investigate the soluble expression of the product
Fischer, Markus +4 more
openaire +4 more sources