Results 11 to 20 of about 1,282,638 (192)

Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides. [PDF]

PLoS ONE, 2009
BACKGROUND: The alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Cherie E Bond, Martina Zimmermann, Susan A Greenfield   +2 more
doaj   +3 more sources

Alpha7 nicotinic acetylcholine receptor activation attenuates allergic airway inflammation and is associated with heme oxygenase-1 induction [PDF]

Frontiers in Immunology
BackgroundActivation of the α7 nicotinic acetylcholine receptor (α7nAChR) exerts anti-inflammatory effects; however, its role in allergic airway inflammation remains poorly understood. This study investigated how GTS-21 treatment, consistent with α7nAChR
Jun Iriki, Jun Iriki, Susumu Fukahori, Yasushi Obase, Yasushi Obase, Yasuna Nakamura, Ryusuke Umene, Ryusuke Umene, Chia-Hsien Wu, Yuri Yamada, Yuri Yamada, Shinnosuke Takemoto, Takahiro Takazono, Takahiro Takazono, Noriho Sakamoto, Chizu Fukushima, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae, Hiroshi Mukae, Tsuyoshi Inoue   +20 more
doaj   +2 more sources

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig [PDF]

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +2 more sources

Autophagy Plays an Important Role in Anti-inflammatory Mechanisms Stimulated by Alpha7 Nicotinic Acetylcholine Receptor [PDF]

Frontiers in Immunology, 2017
Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been reported to alleviate neuroinflammation. Here, we aimed to determine the role of autophagy in α7nAChR-mediated inhibition of neuroinflammation and its underlying mechanism.
Bo-Zong Shao, Ping Ke, Zhe-Qi Xu, Wei Wei, Ming-He Cheng, Bin-Ze Han, Xiong-Wen Chen, Ding-Feng Su, Chong Liu   +8 more
doaj   +2 more sources

Vagus nerve control of HMGB1 accessibility: a bioelectronic strategy for inflammation and pain [PDF]

Bioelectronic Medicine
High mobility group box 1 protein (HMGB1) is a central mediator of inflammation and pain, but efforts to neutralize it therapeutically have had limited clinical success.
Huan Yang, Michael Brines, Ulf Andersson
doaj   +2 more sources

A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain [PDF]

Proceedings of the National Academy of Sciences, 2001
We describe the construction of a soluble protein carrying the N-terminal extracellular domain (ECD) of the α7 subunit of the nicotinic acetylcholine receptor. The approach was to fuse the α7 ECD at the C and N termini of several monomeric and pentameric soluble carrier proteins and to investigate the soluble expression of the
Fischer, Markus, Corringer, Pierre-Jean, Schott, Karin, Bacher, Adelbert, Changeux, Jean-Pierre   +4 more
openaire   +4 more sources

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction. [PDF]

Clin Sci (Lond), 2022
Abstract Cigarette smoking remains the leading modifiable risk factor for cardiopulmonary diseases; however, the effects of nicotine alone on cardiopulmonary function remain largely unknown. Previously, we have shown that chronic nicotine vapor inhalation in mice leads to the development of pulmonary hypertension (PH) with right ...
Whitehead AK, Fried ND, Li Z, Neelamegam K, Pearson CS, LaPenna KB, Sharp TE, Lefer DJ, Lazartigues E, Gardner JD, Yue X.   +10 more
europepmc   +3 more sources

The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein

Frontiers in Cellular and Infection Microbiology
The rabies virus enters the nervous system by interacting with several molecular targets on host cells to modify behavior and trigger receptor-mediated endocytosis of the virion by poorly understood mechanisms.
Brittany C. V. O’Brien, Shelly Thao, Lahra Weber, Helen L. Danielson, Agatha D. Boldt, Karsten Hueffer, Maegan M. Weltzin   +6 more
doaj   +3 more sources

Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.

, 2000
Two homomer-forming nicotinic acetylcholine receptor subunits with 47% identity in their amino acid sequences were employed to compare the actions of cholinergic anthelmintics and ivermectin on expressed vertebrate and nematode nicotinic receptors of ...
Sattelle, D B, Mongan, N P, Raymond, V
core   +10 more sources

Cholinergic anti-inflammatory pathway and COVID-19 [PDF]

BioImpacts, 2022
The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it ...
Danial Mehranfard, Robert C. Speth
doaj   +1 more source