Results 21 to 30 of about 2,877 (196)

Development of a novel alpha7-nicotinic acetylcholine receptor-selective cell-penetrating peptide for intracellular cargo transport [PDF]

Drug Delivery
Cell membranes present barriers to the intracellular delivery of therapeutic agents. This impediment is frequently exacerbated by the hydrophobic characteristics of many such molecules, ultimately reducing the efficiency of their cellular uptake and ...
Lahra Weber, Brittany C. V. O’Brien, Maegan M. Weltzin   +2 more
doaj   +2 more sources

Alpha7 nicotinic acetylcholine receptor activation attenuates allergic airway inflammation and is associated with heme oxygenase-1 induction [PDF]

Frontiers in Immunology
BackgroundActivation of the α7 nicotinic acetylcholine receptor (α7nAChR) exerts anti-inflammatory effects; however, its role in allergic airway inflammation remains poorly understood. This study investigated how GTS-21 treatment, consistent with α7nAChR
Jun Iriki, Jun Iriki, Susumu Fukahori, Yasushi Obase, Yasushi Obase, Yasuna Nakamura, Ryusuke Umene, Ryusuke Umene, Chia-Hsien Wu, Yuri Yamada, Yuri Yamada, Shinnosuke Takemoto, Takahiro Takazono, Takahiro Takazono, Noriho Sakamoto, Chizu Fukushima, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae, Hiroshi Mukae, Tsuyoshi Inoue   +20 more
doaj   +2 more sources

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig [PDF]

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +2 more sources

α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation

Journal of Pain Research, 2018
Qing Liu,1 Chaoyang Liu,1 Li Jiang,1 Maolin Li,1 Ting Long,1 Wei He,1 Guangcheng Qin,2 Lixue Chen,2 Jiying Zhou1 1Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China; 2Laboratory Research Center, The ...
Liu Q, Liu C, Jiang L, Li M, Long T, He W, Qin G, Chen L, Zhou J   +8 more
doaj   +1 more source

Cholinergic anti-inflammatory pathway and COVID-19 [PDF]

BioImpacts, 2022
The cholinergic anti-inflammatory pathway (CAP) first described by Wang et al, 2003 has contemporary interest arising from the COVID-19 pandemic. While tobacco smoking has been considered an aggravating factor in the severity of COVID-19 infections, it ...
Danial Mehranfard, Robert C. Speth
doaj   +1 more source

23. PROBING THE ROLE OF THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR IN PSYCHOSIS [PDF]

Schizophr Bull, 2019
Sawa A.
europepmc   +3 more sources

Nicotinic Acetylcholine Receptor Subunit Alpha-7 Mediates PD-L1 and CTLA-4 Expression in HepG2 Cells [PDF]

ImmunoAnalysis, 2021
Background: The liver is the largest solid organ in the body and has several unique immunological roles. The alpha7 subtype of nicotinic acetylcholine receptor (α7nAChR) is expressed in the liver and has different immunoregulatory effects.
Mina Afrashteh Nour, Fatemeh Kheradmand, Yousef Rasmi, Zahra Asadzadeh, Mohammad Amin Doustvandi, Mahdi Jafarlou, Khalil Hajiasgharzadeh, Behzad Baradaran   +7 more
doaj   +1 more source

[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. [PDF]

PLoS ONE, 2008
BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Kenji Hashimoto, Shingo Nishiyama, Hiroyuki Ohba, Masaaki Matsuo, Tatsuhiko Kobashi, Makoto Takahagi, Masaomi Iyo, Takeru Kitashoji, Hideo Tsukada   +8 more
doaj   +1 more source

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. [PDF]

PLoS Computational Biology, 2006
The initial coupling between ligand binding and channel gating in the human alpha7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-
Xiaolin Cheng, Hailong Wang, Barry Grant, Steven M Sine, J Andrew McCammon   +4 more
doaj   +1 more source

Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure

Frontiers in Immunology, 2020
Nicotine acts as a potent modulator of normal cellular responses through the nicotinic acetylcholine receptor subtype alpha7. In a mouse genetic model of alpha7 receptor dysfunction, alpha7E260A:G, 85 percent of 18 month-old mice exhibit an age ...
Scott W. Rogers, Scott W. Rogers, Elizabeth J. Myers, Lorise C. Gahring, Lorise C. Gahring   +4 more
doaj   +1 more source