Results 231 to 240 of about 67,038 (301)

In silico peptide self‐assembly reveals the importance of N‐terminal motifs and the inhibition mechanism of the mutation L38M in α‐synuclein fibrillation

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Alpha‐synuclein (αSyn) is a presynaptic protein associated with several neurodegenerative diseases. While the non‐amyloid component (NAC) region of the αSyn sequence (residues 65–90) forms the core of all αSyn fibrils, recent findings suggest that the flanking regions play a key role in initiating or preventing amyloid formation. Two motifs in
Van T. T. Nguyen, Sabine M. Ulamec, David J. Brockwell, Sheena E. Radford, Carol K. Hall   +4 more
wiley   +1 more source

The extent of alpha-synuclein aggregate accumulation in neurons varies depending on the type of neurotransmitter they release. [PDF]

Sci Rep
Kameda H, Okamoto S, Ogasawara K, Okuzumi A, Hattori N, Hioki H, Koike M.   +6 more
europepmc   +1 more source

Scalable assay to identify inhibitors of prion‐like propagation of protein misfolding as potential therapeutics for neurodegeneration

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Protein misfolding is linked to many neurodegenerative diseases. In some cases, misfolding can propagate through a prion‐like mechanism whereby natively folded molecules are converted into more copies of the misfolded isoform. Prion‐like propagation of misfolding is an attractive therapeutic target, but difficulties with assaying conversion ...
Abhishek Narayan, Krishna Neupane, Michael T. Woodside   +2 more
wiley   +1 more source

Evaluation of an antibody panel for alpha-synuclein detection in FFPE rectal biopsies in Parkinson's disease. [PDF]

IBRO Neurosci Rep
Schröder K, Kintrup C, Kulcsárová K, Heinzel S, Kluge A, Wedel T, Böttner M, Lucius R, Pendziwiat M, Schoch S, Ellrichmann M, Berg D, Schaeffer E, Cossais F.   +13 more
europepmc   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, Volume 177, Issue 4, Page 736-748, April 2026.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology. [PDF]

NPJ Parkinsons Dis
Jeong JY, Kim N, Li Y, Kim DJ, Kim HK, Oh WJ.   +5 more
europepmc   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source

Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles

Braun T, Tiberi C, Reber V, Ghosh D, Riek R, Serdiuk T.   +5 more
europepmc   +1 more source

Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria. [PDF]

Nat Commun
Serdiuk T, Fleischmann Y, Ghosh D, Delparente A, Reber V, Frey L, Rhyner D, Gerez J, Volkmar N, Kralickova L, Mas G, Dörig C, Hiller S, Schibli R, Mu L, Picotti P, Riek R.   +16 more
europepmc   +1 more source