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Alpha-synuclein overexpression does not cause vocalization deficits in a mouse model of parkinsonism. [PDF]

Biol Open
Rodgers B, Schaser A.
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Prevalence of Alpha-Synuclein Seeding Activity in the Olfactory Mucosa following SARS-CoV-2 Infection - Results from a Pilot Study

Poewe W, Heim B, Seppi K, De Cleene N, Bongianni M, Bronzato E, Cerejo C, Jagusch F, Kindl P, Löffler-Ragg J, Weiss G, Gottfried T, Schmutzhard J, Zanusso G.   +13 more
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Alpha-synuclein and Parkinson's disease

Cellular and Molecular Life Sciences, 2000
The involvement of alpha-synuclein in neurodegenerative diseases was first suspected after the isolation of an alpha-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different alpha-synuclein mutations were shown to be associated with autosomal-dominant Parkinson's disease (PD), but only in a small number of ...
C B, Lücking, A, Brice
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Prion Properties of Alpha-Synuclein

Molecular Biology, 2019
The prion properties of alpha-synuclein, a key aggregating protein involved in the pathogenesis of so-called synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and its various conformers are discussed.
A L, Schwarzman, K A, Senkevich, A K, Emelyanov, S N, Pchelina   +3 more
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Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity

Molecular Biology Reports, 2009
Alpha-synuclein aggregation and cytotoxicity are widely considered to play a critical role in the process of Parkinson's disease. Heat shock proteins are a large family of cellular protective molecules in most kinds of cells. In this study, we examined the impact of dominant-positive heat shock transcription factor 1 (HSF1) on alpha-synuclein over ...
Xu, Liangliang, Hou, Yonghui, E, Shunmei, Gong, Shoufang, Zhou, Wei, Zou, Jiangying   +5 more
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Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.

Human molecular genetics, 2006
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar aggregates of alpha-synuclein in characteristic inclusions known as "Lewy bodies". As mutations altering alpha-synuclein structure or increasing alpha-synuclein expression level can cause familial forms of PD or related Lewy body disorders, alpha-synuclein is believed ...
Yuxin, Fan, Pornprot, Limprasert, Ian V J, Murray, Annette C, Smith, Virginia M-Y, Lee, John Q, Trojanowski, Bryce L, Sopher, Albert R, La Spada   +7 more
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Alpha-synuclein and Parkinson's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004
Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in alpha-syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease (PD). The physiological functions of alpha-
RECCHIA, ALESSANDRA, DEBETTO, PATRIZIA, NEGRO, ALESSANDRO, GUIDOLIN, DIEGO, SKAPER SD, GIUSTI, PIETRO   +5 more
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Dimerization of Tyr136Cys alpha-synuclein prevents amyloid transformation of wild type alpha-synuclein

International Journal of Biological Macromolecules, 2017
Expression of human alpha-synuclein in E. coli cells is known to result in a mixture of the wild type alpha-synuclein and the protein containing Tyr136Cys substitution due to the translational error. The amount of Cys136 alpha-synuclein (Cys136-AS) may reach approximately 50% of the recombinant protein.
K V, Barinova, M L, Kuravsky, A M, Arutyunyan, M V, Serebryakova, E V, Schmalhausen, V I, Muronetz   +5 more
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