Results 31 to 40 of about 67,038 (301)
Scientific Reports, 2023 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need.
Danuta Sastre +7 more
doaj +1 more source
Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]
, 2019 Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola +4 more
core +1 more source
Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]
, 2015 Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY +5 more
core +2 more sources
Journal of Analytical Methods in Chemistry, 2019 Parkinson’s disease (PD) is a progressive health issue and influences an increasingly larger number of people, especially at older ages, affecting the central nervous system (CNS).
Xuemei You +3 more
doaj +1 more source
Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
Frontiers in Cellular Neuroscience, 2021 Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions.
Alix Booms, Gerhard A. Coetzee
doaj +1 more source
The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]
, 2011 Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra +9 more
core +1 more source
Dopamine-induced conformational changes in alpha-synuclein. [PDF]
PLoS ONE, 2009 Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using ...
Tiago F Outeiro +8 more
doaj +1 more source
Localization of α-synuclein in teleost central nervous system: immunohistochemical and Western blot evidence by 3D5 monoclonal antibody in the common carp, Cyprinus carpio [PDF]
, 2015 Alpha synuclein (α-syn) is a 140 amino acid vertebrate-specific protein, highly expressed in the human nervous system and abnormally accumulated in Parkinson's disease and other neurodegenerative disorders, known as synucleinopathies.
CASINI, Arianna +6 more
core +1 more source
Alpha Synuclein: Neurodegeneration and Inflammation
International Journal of Molecular Sciences, 2023 Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson’s disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role. This review analyzes the activities of α-Syn, in different conformational states, monomeric, oligomeric and fibrils ...
openaire +2 more sources
p27Kip1 regulates alpha-synuclein expression
Oncotarget, 2018 Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However, the mechanisms involved in its transcriptional regulation are poorly understood.
Gallastegui Calvache, Edurne, 1982- +12 more
openaire +5 more sources