Results 31 to 40 of about 67,783 (305)
Journal of Analytical Methods in Chemistry, 2019 Parkinson’s disease (PD) is a progressive health issue and influences an increasingly larger number of people, especially at older ages, affecting the central nervous system (CNS).
Xuemei You +3 more
doaj +1 more source
Scientific Reports, 2023 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need.
Danuta Sastre +7 more
doaj +1 more source
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
core +3 more sources
Free Neuropathology, 2020 Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties.
Ellen Gelpi +7 more
doaj +1 more source
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]
, 2015 Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R +8 more
core +2 more sources
Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
Frontiers in Cellular Neuroscience, 2021 Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions.
Alix Booms, Gerhard A. Coetzee
doaj +1 more source
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]
, 2017 Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T +9 more
core +1 more source
Dopamine-induced conformational changes in alpha-synuclein. [PDF]
PLoS ONE, 2009 Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using ...
Tiago F Outeiro +8 more
doaj +1 more source
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein. [PDF]
, 2014 Accumulation and aggregation of alpha-synuclein in cortical and hippocampal areas is a pathological sign for dementia with Lewy bodies (DLB) and Parkinson's disease with dementia.
Anichtchik, Oleg +4 more
core +2 more sources
Alpha Synuclein: Neurodegeneration and Inflammation
International Journal of Molecular Sciences, 2023 Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson’s disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role. This review analyzes the activities of α-Syn, in different conformational states, monomeric, oligomeric and fibrils ...
openaire +2 more sources