Results 71 to 80 of about 67,038 (301)

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases. [PDF]

PLoS ONE, 2018
Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.
Thomas Mund, Masami Masuda-Suzukake, Michel Goedert, Hugh R Pelham   +3 more
doaj   +1 more source

Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson's disease [PDF]

, 2017
Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies.
Abbas-Terki, Toufik, Aebischer, Patrick, Azeredo da Silveira, Samareh, Cifuentes-Diaz, Carmen, Iwatsubo, Takeshi, Sage, Daniel, Schneider, Bernard L., Unser, Michaël   +7 more
core  

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Dual-probe sandwich for Lewy body detection on nano-composite modified dielectric surface to determine Parkinson's disease

Sensing and Bio-Sensing Research, 2023
Parkinson's disorder (PD) is a chronic and central nervous system disorder that occurs when neurons in the area of the brain impairs or dies, in particular, it affects the dopamine-producing neurons.
Xi Zhang, Menghai Wu, Subash C.B. Gopinath, Yeng Chen   +3 more
doaj   +1 more source

Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies

Journal of Parkinson's Disease, 2022
Background: Alpha-synucleinopathies (AS) are characterized by pathologic aggregations of alpha-synuclein (α-syn) in the central nervous system, and comprise dementia with Lewy bodies, Parkinson’s disease, and multiple system atrophy. Previous studies on AS have reported findings of α-syn pathology in the peripheral nervous system of multiple organs ...
Javanshiri, Keivan, Drakenberg, Tove, Haglund, Mattias, Englund, Elisabet   +3 more
openaire   +2 more sources

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein. [PDF]

, 2014
BackgroundSleep disruptions occur early and frequently in Parkinson's disease (PD). PD patients also show a slowing of resting state activity. Alpha-synuclein is causally linked to PD and accumulates in sleep-related brain regions.
Chesselet, Marie-Françoise, McDowell, Kimberly A, Roos, Kenneth P, Shin, David   +3 more
core  

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. [PDF]

, 2018
SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD ...
Deng, Yong-Ning, Li, Yan-Bo, Liu, Jie, Qu, Qiu-Min, Su, Hua, Zhang, Jing-Yi, Zhang, Meng   +6 more
core   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson\xe2\x80\x99s disease [PDF]

, 2018
The involvement of DNA damage and repair in aging processes is well established. Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into the role that DNA alterations may have in the ...
Blandini, F. (Fabio), Cerri, S. (Silvia), Di Monte, D.A. (Donato A.), Gabriels, S. (Sylvia), Gornati, S.V. (Simona), Hoeijmakers, J.H.J. (Jan), Mastroberardino, P.G. (Pier), Milanese, C. (Chiara), Plat, A. (Audrey), Ulusoy, A. (Ayse)   +9 more
core   +4 more sources