Results 111 to 120 of about 3,505,696 (258)

An arm length stabilization system for KAGRA and future gravitational-wave detectors [PDF]

, 2020
Modern ground-based gravitational wave (GW) detectors require a complex interferometer configuration with multiple coupled optical cavities. Since achieving the resonances of the arm cavities is the most challenging among the lock acquisition processes ...
Akutsu, T., Arai, K., Kumar, R.
core  

Post-Translational Modification Analysis of VDAC1 in ALS-SOD1 Model Cells Reveals Specific Asparagine and Glutamine Deamidation [PDF]

, 2020
Maria Gaetana Giovanna Pittalà, Simona Reina, Salvatore Antonio Maria Cubisino, Annamaria Cucina, Beatrice Formicola, Vincenzo Cunsolo, Salvatore Foti, Rosaria Saletti, Angela Messina   +8 more
openalex   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Genetic alterations of C9orf72, SOD1, TARDBP, FUS, and UBQLN2 genes in patients with Amyotrophic Lateral Sclerosis

Cogent Medicine, 2019
Amyotrophic lateral sclerosis is the most common motor neuron disease of the adulthood. Genetic analyses performed on cases with sporadic ALS (sALS) and familial ALS (fALS) have revealed mutations most commonly in the genes C9orf72, SOD1, TARDBP, FUS ...
Ciftci Vildan, Darbas Sule, Bilgen Turker, Uysal Hilmi, Karauzum Berker Sibel   +4 more
doaj   +1 more source

The S100A4 Transcriptional Inhibitor Niclosamide Reduces Pro-Inflammatory and Migratory Phenotypes of Microglia: Implications for Amyotrophic Lateral Sclerosis

Cells, 2019
S100A4, belonging to a large multifunctional S100 protein family, is a Ca2+-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types.
Alessia Serrano, Savina Apolloni, Simona Rossi, Serena Lattante, Mario Sabatelli, Mina Peric, Pavle Andjus, Fabrizio Michetti, Maria Teresa Carrì, Mauro Cozzolino, Nadia D’Ambrosi   +10 more
doaj   +1 more source

Gymnasial Buildings and Sanctuaries. A Contribution to the Formation of the Palaestra and an Interpretation of the So-Called ‘Echo Stoa’ [PDF]

, 2018
Das Aufkommen der Palästra als Gebäude in Form eines Peristyls kann ins letzte Drittel des 4. Jhs. v. Chr. datiert werden, wobei die schriftlichen Quellen zeigen, dass es bereits früher Palästren gab.
Mania, Ulrich
core   +1 more source

SOD1 Protein Content in Human Central Nervous System and Peripheral Tissues

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Disease‐modifying treatments targeting the core pathological process for SOD1‐linked amyotrophic lateral sclerosis (ALS) are becoming available. Much evidence suggests that misfolding and aggregation of the SOD1 protein cause proteotoxicity, and inhibition of SOD1 expression shows a good effect in many ALS patients.
Laura Leykam, P. Andreas Jonsson, Karin M. E. Forsberg, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund, Per Zetterström   +6 more
wiley   +1 more source

TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis

Cells, 2019
Cytoplasmic TDP-43 aggregates are a hallmark of amyotrophic lateral sclerosis (ALS). Today, only two drugs are available for ALS treatment, and their modest effect prompts researchers to search for new therapeutic options.
Débora Lanznaster, Jérôme Bourgeais, Clement Bruno, Rudolf C. Hergesheimer, Rose-Anne Thepault, Patrick Vourc’h, Philippe Corcia, Christian R. Andres, Olivier Herault, Hélène Blasco   +9 more
doaj   +1 more source

AL-ADAB AL-ISLAMI BAINA AL-QIYAM AL-KHULUQIYAH WA AL-JAWANIB AL-FANNIYAH

Arabiyat : Jurnal Pendidikan Bahasa Arab dan Kebahasaaraban, 2015
Art is the formal study of moral standard and correct. The term ethics and morality are often used interchangeably indeed. They usually can mean the something, and in casual conversation. There isn't a problem with switching between one and other when discussing morality it is important to distinguish between morals and values.
openaire   +3 more sources

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD

Communications Biology
Expanded intronic G4C2 repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These intronic repeats are translated through a non-AUG-dependent mechanism into five different dipeptide repeat proteins ...
M. E. Cicardi, V. Kankate, S. Sriramoji, K. Krishnamurthy, S. S. Markandaiah, B. M. Verdone, A. Girdhar, A. Nelson, L. B. Rivas, A. Boehringer, A. R. Haeusler, P. Pasinelli, L. Guo, D. Trotti   +13 more
doaj   +1 more source