Results 101 to 110 of about 3,225,723 (227)
Cogent Medicine, 2019 Amyotrophic lateral sclerosis is the most common motor neuron disease of the adulthood. Genetic analyses performed on cases with sporadic ALS (sALS) and familial ALS (fALS) have revealed mutations most commonly in the genes C9orf72, SOD1, TARDBP, FUS ...
Ciftci Vildan +4 more
doaj +1 more source
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. [PDF]
, 2019 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43).
Artates, Jon W +19 more
core
Promoting Independence Through Effective Interventions For Adults With ALS [PDF]
, 2020 PICO Question What are effective occupational therapy interventions for adults with ALS to improve participation in ADLs/IADLs? Objectives Define amyotrophic lateral sclerosis (ALS) and recognize the prevalence Identify and describe evidence-based ...
Gluchowski, OTS, Renee +4 more
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Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]
, 2018 Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong +4 more
core +2 more sources
Glia, Volume 74, Issue 1, January 2026.Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao +9 more
wiley +1 more source
Cells, 2019 S100A4, belonging to a large multifunctional S100 protein family, is a Ca2+-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types.
Alessia Serrano +10 more
doaj +1 more source
Administrative License Suspensions, Criminal Prosecution and the Double Jeopardy Clause [PDF]
, 1996 This Note argues that revocation of a driver\u27s license under ALS proceedings is not a bar to subsequent criminal prosecution by the state. It discusses the potential double jeopardy implications surrounding ALS that is followed by criminal ...
Ramirez, Carlos F.
core +1 more source
FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis [PDF]
, 2017 The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown.
Alfano, Vincenzo +7 more
core +2 more sources
Islam Nusantara: Journal for the Study of Islamic History and Culture, 2022 Abstract For approximately five centuries, starting from 1571 and actually ending in 1924, the Ottoman Empire controlled the scientific centers in the Hejaz City. During that time, Ulama Jawi enjoyed the golden age of science. Thoriq Aziz, in his book entitled "Ulama-Ulama Nusantara yang Mempengaruhi Dunia" documented at least three Ulama from ...
openaire +1 more source
Cells, 2019 Cytoplasmic TDP-43 aggregates are a hallmark of amyotrophic lateral sclerosis (ALS). Today, only two drugs are available for ALS treatment, and their modest effect prompts researchers to search for new therapeutic options.
Débora Lanznaster +9 more
doaj +1 more source