Results 111 to 120 of about 2,739,321 (263)
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, Volume 13, Issue 17, 23 March 2026.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
ALS Focus Wave 3 – Caregiver Needs Survey
The NeuroVERSE record contains the following files: ALSFocusWave3_DataDictionary.xlsx – This is the data dictionary for surveys fielded in ALS Focus Wave 3.
The ALS Association
core +1 more source
Cogent Medicine, 2019 Amyotrophic lateral sclerosis is the most common motor neuron disease of the adulthood. Genetic analyses performed on cases with sporadic ALS (sALS) and familial ALS (fALS) have revealed mutations most commonly in the genes C9orf72, SOD1, TARDBP, FUS ...
Ciftci Vildan +4 more
doaj +1 more source
CD38 in Neurodegeneration and Neuroinflammation
Cells, 2020 Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro +3 more
doaj +1 more source
Al-Ittijah al-Ṣūfī wa al-Adab al-Sāmī fī al-Adab al-Indūnīsī al-Mu’āṣir
Studia Islamika, 1970 The article is a study on the strength of the sûfi elements in modern Indonesian literary discourse. Having explored the discourse on Sufism in the works of literature by the sûfi poets mentioned above, the article discusses the socio-political and religious context in which this transcendental literature emerged.
openaire +2 more sources
Value of Clinical Evidence and Health Economics and Outcomes Research (HEOR) Studies
Muscle &Nerve, Volume 73, Issue S1, Page S7-S12, February 2026.ABSTRACT Randomized controlled trials (RCTs) remain the gold standard for establishing the efficacy and safety of new treatments. However, clinical evidence derived from the systematic analysis of real‐world data generated through routine clinical practice can complement RCT data by offering insights into treatment performance in broader, more ...
Agessandro Abrahao +2 more
wiley +1 more source
Studia Islamika, 2015 The article describes the transformation process of political Islam in Indonesia. Focusing on the early development period of the New Order regime, the paper seeks to examine how the period of intense conflict between Islamic political movements and the State was successfully resolved in the political arena.
openaire +2 more sources
Study 19 (MCI186‐19) Post Hoc Analyses
Muscle &Nerve, Volume 73, Issue S1, Page S19-S22, February 2026.ABSTRACT While randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy of therapies in amyotrophic lateral sclerosis (ALS), post hoc analyses can provide critical insights into clinical effectiveness, treatment durability, and subpopulation responses.
Benjamin Rix Brooks +2 more
wiley +1 more source
ALS Focus Wave 2 - What Matters Most Survey
This Dataverse record contains the following files: ALSFocusWave2_DataDictionary.xlsx – This is the data dictionary for all surveys fielded in ALS Focus Wave 2.
The ALS Association
core +1 more source
Current and Ongoing Clinical Studies
Muscle &Nerve, Volume 73, Issue S1, Page S26-S28, February 2026.ABSTRACT This article provides a comprehensive overview of current and ongoing studies evaluating intravenous (IV) edaravone and edaravone oral suspension in the treatment of amyotrophic lateral sclerosis (ALS). In addition to data from clinical practice and post hoc analyses, multiple observational and interventional studies are underway to better ...
Agessandro Abrahao +2 more
wiley +1 more source