Results 91 to 100 of about 3,225,723 (227)

An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases

Microbial Cell
TDP-43 is linked to human diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Expression of TDP-43 in yeast is known to be toxic, cause cells to elongate, form liquid-like aggregates, and inhibit autophagy and ...
Sangeun Park, Sei-Kyoung Park, Peter Blair, Susan W. Liebman   +3 more
doaj   +1 more source

CD38 in Neurodegeneration and Neuroinflammation

Cells, 2020
Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro, Anne-Laure Privat, Laurence Bressac, Damien Toulorge   +3 more
doaj   +1 more source

Al-Âyah al-Mutasyâbihât al-Lafzhiyyah fi Sûrah al-An’âm ‘Inda al-Kirmâny

Studia Quranika, 2017
This paper discusses about the verses of mutasyâbihât in the Quran. The debate of this versescaused various opinions. The meaning of the mutasyâbihât in this paper is the similarity and difference of the words in the Qur'an. Mufasir have different opinion about the meaning of the verse of mutasyâbihât al-lafdzi.
Hikmatiar Pasya, Muhammad Iqbal Rivai
openaire   +3 more sources

Glycoprotein Non‐Metastatic Melanoma Protein B (GPNMB): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition With VRG50635

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Glycoprotein non‐metastatic melanoma protein B (GPNMB) was investigated as a pharmacodynamic (PD) biomarker for PIKfyve inhibition across translational studies ex vivo, in vitro, in animals, and in the clinic, demonstrating significant response to VRG50468 in cells, in vivo in the central nervous system (CNS) and in peripheral fluids and ...
Geraldine Gontier, Grace Kim, Chao Wang, Kevin Zhu, Raymond Gau, Ningzhe Zhang, Swati Naphade, Alistair Stewart, Martin J. Schmidt, Robert Galemmo, Brian Shook, Anil Tarachandani, Irene Choi, Shane Raines, Robert H. Scannevin, Henrieke W. Grievink, Lars M. G. Smits, Philip H. C. Kremer, Diego Cadavid   +18 more
wiley   +1 more source

Retinal Damage in Amyotrophic Lateral Sclerosis: Underlying Mechanisms

Eye and Brain, 2021
Vladislav O Soldatov,1,2 Michail S Kukharsky,3,4 Andrey E Belykh,5 Andrey M Sobolev,4 Alexey V Deykin2,6 1Core Facility Centre, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia; 2Department of Pharmacology and Clinical Pharmacology,
Soldatov VO, Kukharsky MS, Belykh AE, Sobolev AM, Deykin AV   +4 more
doaj  

A High-throughput qPCR-based Method to Genotype the SOD1G93A Mouse Model for Relative Copy Number

Bio-Protocol, 2019
The most commonly used mouse model in ALS preclinical research expresses multiple copies of the human SOD1 (G93A) transgene. During the course of breeding, successive generations of mice can lose copies of the transgene. Because shorter lifespan of these
Valerie Tassinari, Fernando Vieira
doaj   +1 more source

An arm length stabilization system for KAGRA and future gravitational-wave detectors [PDF]

, 2020
Modern ground-based gravitational wave (GW) detectors require a complex interferometer configuration with multiple coupled optical cavities. Since achieving the resonances of the arm cavities is the most challenging among the lock acquisition processes ...
Akutsu, T., Arai, K., Kumar, R.
core  

Health-related quality of life and functional changes in DMD:A 12-month longitudinal cohort study [PDF]

, 2016
Family caregivers of people with amyotrophic lateral sclerosis (ALS) live stressful lives in which they spend most of their time caring for their loved ones and managing difficult situations, thereby reducing the time spent in taking care of themselves ...
Baranello, G, Barcellona, C, Berardinelli, A., Bertini, E, Bruno, C, D\u2019Amico, A, D\u2019Angelo, M. G., Distefano, M. G., La Rosa, M, Marcato, S, Mazzone, E, Mercuri, E., Messina, S, Minetti, C, Mongini, T, Morandi, L, Palmieri, Arianna, Pane, M, Pegoraro, Elena, Politano, L, Rodolico, C, Scutifero, M, Sframeli M., Mondello S, Vita G., L, Vita, E   +24 more
core   +1 more source

Asalib Ta’allum al-Mu’allimy al-Dirasat al-Islamiyah Fi al-Dirasat al-‘Ulya

AJIS: Academic Journal of Islamic Studies, 2019
This study describes and identifies the learning styles of teachers who are undergoing a postgraduate course in Islamic studies. Using the quantitative descriptive method, with 27 subjects in the research subject, there is a second semester of the academic year 20018/2019 postgraduate program at Raden Rahmat Islamic University Malang, Indonesia.
Mufidah, Nuril, Kholis, Nur
openaire   +3 more sources

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 131-143, January 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source