Results 71 to 80 of about 2,739,321 (263)

Al-Maujah al-Islāmiyyah al-Ukhrā: Al-Istisyrāq wa al-Dirāsāt al-Islāmiyyah al-Mu‘āṣirah

open access: yesAl-Jami'ah: Journal of Islamic Studies, 2007
This article explores the mapping of the development of Islamic studies from its inception to the present, which consists of three waves. The first wave was the study of Islam by internal Muslims themselves. This period lacks comprehensive factors to categorize as an academic study.
openaire   +1 more source

Validation of the German version of the Dimensional Apathy Scale (G‐DAS): Application in amyotrophic lateral sclerosis

open access: yesJournal of Neuropsychology, EarlyView.
Abstract Apathy is a common behavioural impairment in neurodegenerative conditions and is conceptualized within the Dimensional Apathy Framework as comprising Executive, Emotional and Initiation subtypes. The Dimensional Apathy Scale (DAS) is widely used to assess these domains, yet no validated German version has been available.
Judith Wesenberg   +6 more
wiley   +1 more source

Psychometric Properties of Cognitive Assessment in Amyotrophic Lateral Sclerosis: A Systematic Review

open access: yesPatient Related Outcome Measures, 2020
Tina Taule,1 Margaret Søvik,2 Regina Küfner Lein,3 Eike Wehling,4,5 Jörg Aßmus,6 Tiina Rekand7,8 1Department of Occupational Therapy, Haukeland University Hospital (HUH), Bergen, Norway; 2Department of Health and Functioning ...
Taule T   +5 more
doaj  

Al-‘Unfu fî al-Tarbiyah min Mandzûr al-Tashrî’ al-Indûnîsî wa al-Sharî’ah al-Islâmiyah

open access: yesAL-IHKAM: Jurnal Hukum & Pranata Sosial, 2022
Violence on children has become a big unsolvable problem in Indonesian education. In fact, the government has ratified some Laws to protect them from any form of violence. Likely, Islam as the mostly followed religion in the country does the same through its mission called rahmatan li al-alamin or blessing for all. This research relies on a question on
Mohammad Kosim   +2 more
openaire   +2 more sources

Perceptions of Speech‐Language Pathology Care in Amyotrophic Lateral Sclerosis: A Patient‐Centered Exploratory Study

open access: yesMuscle &Nerve, Volume 74, Issue 1, Page 216-224, July 2026.
ABSTRACT Introduction/Aims Given limited research on patient perspectives of speech‐language pathology (SLP) services in ALS care, this study aimed to assess the satisfaction with, and understanding of, SLP services by people with ALS (pwALS) and to examine the alignment between services received and patient‐reported impairments.
Jennafer D. Best   +3 more
wiley   +1 more source

RIPK1 Mediates Axonal Degeneration By Promoting Inflammation and Necroptosis in ALS

open access: yesScience, 2016
Axonal pathology and necroptosis in ALS Necroptosis, a non–caspase-dependent form of cell death, can be reduced in disease states by inhibiting a kinase called RIPK1. Until now, no human mutations have been linked to necroptosis. Ito et al.
Yasushi Ito   +20 more
semanticscholar   +1 more source

THE EFFECT OF DOPING BY CD AND PB ON THE OPTICAL PROPERTIES OF THIN FILM (CU0.5AG0.5ALS2 ) [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة, 2009
:Cu0.5Ag0.5AlS2 thin film had been doped by (Cd) and (Pb) elements, with amount of (1, 2, 3, 4, 5)wt% and studied the effect of doping by Cd and Pb on the optical properties for this thin film which prepared by chemical spray pyrolysis at 360Co .When the
HAMID S. ABTAN, AHMED KH. IBRAHEEM
doaj   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

open access: yesThe FEBS Journal, Volume 293, Issue 12, Page 3485-3501, June 2026.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh   +2 more
wiley   +1 more source

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

open access: yesbioRxiv, 2019
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several inherited pathogenic mutations have been identified as causative, the vast majority of cases are sporadic with ...
O. Tam   +60 more
semanticscholar   +1 more source

Holding but not folding: How a single charge flip uncouples the DNAJC7‐Hsp70 relay in amyotrophic lateral sclerosis

open access: yesThe FEBS Journal, Volume 293, Issue 12, Page 3466-3469, June 2026.
In this issue, Elmaleh et al. demonstrate that the E425K mutation in DNAJC7, associated with amyotrophic lateral sclerosis, selectively abolishes one of a co‐chaperone's dual functions. High‐resolution NMR confirmed that the mutation leaves the protein's structure intact while paralyzing its communication with the Hsp70 machinery.
Tsung‐Sheng Chiang   +2 more
wiley   +1 more source

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