Results 71 to 80 of about 3,225,723 (227)

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the
Annu, Kavya, Baker, Matt, Bigio, Eileen, Boylan, Kevin B., Caselli, Richard J., Dickson, Dennis W., Finger, Elizabeth, Fryer, John D., Graff-Radford, Neill R., Hirsch-Reinshagen, Veronica, Hsiung, Ging-Yuek R., Kato, Masato, Keith, Julia, Kim, Hong Joo, Krieger, Charles, Kurti, Aishe, Lacomis, David, Lippa, Carol, Mackenzie, Ian R., Matchett, Billie J., Messing, James, Mesulam, Marsel, Mittag, Tanja, Murray, Melissa E., Nicholson, Alexandra M., Perkerson, Ralph B., Petersen, Ronald C., Petrucelli, Leonard, Pottier, Cyril, Purice, Maria D., Rademakers, Rosa, Rogaeva, Ekaterina, Roos, Raymond P., Sarkar, Mohona, Stewart, Heather, Taylor, J. Paul, Temirov, Jamshid, Weintraub, Sandra, Wszolek, Zbigniew K., Zinman, Lorne, Zivkovic, Sasha A., Züchner, Stephan   +41 more
core   +2 more sources

Al-Shawkah al-Siyāsīyah li al-Afkār al-Dīnīyah: Al-Ḥarakah al-Tajdīdīyah al-Islāmīyah wa al-ṭarīq ilá Nuqṭat Iltiqā’ al-Islām wa al-Dawlah

Studia Islamika, 2015
The article describes the transformation process of political Islam in Indonesia. Focusing on the early development period of the New Order regime, the paper seeks to examine how the period of intense conflict between Islamic political movements and the State was successfully resolved in the political arena.
openaire   +2 more sources

AL AF’ᾹL AL INJᾹZIYAH LADAY MU’ALLIMAH AL LUGHAH AL ARABIYYAH FI AL TAFᾹ’UL AL SOFFI ASNA’A TA’LIM AL LUGHAH AL ARABIYYAH

Al Mi'yar: Jurnal Ilmiah Pembelajaran Bahasa Arab dan Kebahasaaraban, 2023
<p style="text-align: justify;"><em>Directive Acts are illocution acts a teacher uses to ask the student to do a specific action. This speech act affects the input and output of the language studied. This study aimed to analyze the illocutionary acts used by teachers in learning Arabic at the Al Munawaroh Islamic boarding school, Jombang ...
Lailatul Qomariyah, Akhmad Sauqi Ahya', Isniyatun Niswah MZ   +2 more
openaire   +1 more source

Value of Clinical Evidence and Health Economics and Outcomes Research (HEOR) Studies

Muscle &Nerve, Volume 73, Issue S1, Page S7-S12, February 2026.
ABSTRACT Randomized controlled trials (RCTs) remain the gold standard for establishing the efficacy and safety of new treatments. However, clinical evidence derived from the systematic analysis of real‐world data generated through routine clinical practice can complement RCT data by offering insights into treatment performance in broader, more ...
Agessandro Abrahao, Malgorzata Ciepielewska, Lorne Zinman   +2 more
wiley   +1 more source

The Violent ‘Trojan Horse’: a Comparative, Transnational Reading of Two Paralysis Narratives

European Journal of Life Writing
This article proposes a comparative analysis of two ALS narratives: one written in 2017 by the Spanish businessman and author Francisco Luzón, El Viaje es la recompensa (The Trip is the Reward) and the other published in 1999 by American sociologist ...
Isabel Durán Giménez-Rico
doaj   +1 more source

Characterizing the Spatial Variations of Forest Sunlit and Shaded Components Using Discrete Aerial Lidar

Remote Sensing, 2020
Forest three-dimensional (3-D) structure, in the vertical dimension, consists of at least two components, including overstory and a forest background matrix (i.e., shrubs, grass, and bare earth).
Xiaofei Wang, Guang Zheng, Zengxin Yun, Zhaoshang Xu, L. Monika Moskal, Qingjiu Tian   +5 more
doaj   +1 more source

Al-Ittijah al-Ṣūfī wa al-Adab al-Sāmī fī al-Adab al-Indūnīsī al-Mu’āṣir

Studia Islamika, 1970
The article is a study on the strength of the sûfi elements in modern Indonesian literary discourse.  Having explored the discourse on Sufism in the works of literature by the sûfi poets mentioned above,  the article discusses the socio-political and religious  context in which this transcendental  literature emerged.
openaire   +2 more sources

Taṭwīr al-Wasā’il al-Taʿlīmīyah “Al-Podcast al-ʿArabī” li-Taḥsīn Mahārat al-Istimāʿ al-ʿArabīyah li-Ṭalabat al-Madrasah al-Mutawassiṭah al-Islāmīyah

Alsina : Journal of Arabic Studies, 2023
This research focuses on developing "Arabic Cast," an audio learning media presented as an Android application, aimed at enhancing listening skills in Arabic for 10th grade students at Muhammadiyyah Al-Kautsar Senior High School's Special Program in Kartasura.
Niswa Ikraama, Maslamah Maslamah
openaire   +1 more source

Study 19 (MCI186‐19) Post Hoc Analyses

Muscle &Nerve, Volume 73, Issue S1, Page S19-S22, February 2026.
ABSTRACT While randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy of therapies in amyotrophic lateral sclerosis (ALS), post hoc analyses can provide critical insights into clinical effectiveness, treatment durability, and subpopulation responses.
Benjamin Rix Brooks, Jeremy Shefner, Stephen Apple   +2 more
wiley   +1 more source