Results 61 to 70 of about 3,225,723 (227)

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Safety and feasibility of Lin- cells administration to ALS patients : a novel view on humoral factors and miRNA profiles [PDF]

, 2018
Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular
Baumert, Bartłomiej, Dulak, Józef, Gołąb-Janowska, Monika, Gródecka-Szwajkiewicz, Dorota, Kawa, Miłosz P., Kotowski, Maciej, Litwińska, Zofia, Machaliński, Bogusław, Nowacki, Przemysław, Peregud-Pogorzelski, Jarosław, Pius-Sadowska, Ewa, Sobuś, Anna, Stępniewski, Jacek   +12 more
core   +2 more sources

Holding but not folding: How a single charge flip uncouples the DNAJC7‐Hsp70 relay in amyotrophic lateral sclerosis

The FEBS Journal, EarlyView.
In this issue, Elmaleh et al. demonstrate that the E425K mutation in DNAJC7, associated with amyotrophic lateral sclerosis, selectively abolishes one of a co‐chaperone's dual functions. High‐resolution NMR confirmed that the mutation leaves the protein's structure intact while paralyzing its communication with the Hsp70 machinery.
Tsung‐Sheng Chiang, Jerome Boisbouvier, Lauren A. Gandy   +2 more
wiley   +1 more source

“Silent Echoes of the Day: Dream Content Analysis in Amyotrophic Lateral Sclerosis”

Brain and Behavior, Volume 16, Issue 5, May 2026.
ALS reshapes waking life through motor decline, social withdrawal, loneliness, and altered body image. Consistent with the continuity hypothesis, these changes may persist in dreams. In 68 ALS outpatients, a 7‐night dream diary yielded 127 reports, coded with the Hall–Van de Castle system (DreamSAT).
Alessandro Bombaci, Alessandra Giordano, Ilaria Lavalle, Alice Magnino, Andrea Calvo, Adriano Chiò, Alessandro Cicolin   +6 more
wiley   +1 more source

Expert Consensus on Key Attributes of Nurses in Resuscitation Teams: Findings From a Delphi Study

Nursing in Critical Care, Volume 31, Issue 3, May 2026.
ABSTRACT Background In‐hospital cardiac arrest (IHCA) requires coordinated interdisciplinary action. Nurses are often first responders and essential members of resuscitation teams, yet the attributes that define their effectiveness remain unclear.
George Kipourgos, Nick Bakalis, Eleni Albani, Nikolaos Stefanopoulos, John Lakoumentas, Anastasios Tzenalis   +5 more
wiley   +1 more source

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, Volume 293, Issue 8, Page 2500-2513, April 2026.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 612-617, March 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source

Taḥlīl al-Qiyam al-Akhlāqiyah fī Kitāb al-Qirā’ah al-Rasyīdah al-Juz’ al-Ṡānī (Dirāsah al-Adab al-Ijtimā’ī)

JILSA (Jurnal Ilmu Linguistik dan Sastra Arab), 2022
The objectives of this research are to know and explain an ethical message in the book of Qira>aturrasyi>dah, and to know and explain the form of moral values in the book of of Qira>aturrasyi>dah Part II.. The method of qualitative research, with the social approach to literature the data sources used contain basic data including the book ...
openaire   +1 more source

The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord

Cells, 2020
Understanding the cellular and molecular basis of selective vulnerability has been challenging, especially for motor neuron diseases. Developing drugs that improve the health of neurons that display selective vulnerability relies on in vivo cell-based ...
Baris Genc, Oge Gozutok, Nuran Kocak, P. Hande Ozdinler   +3 more
doaj   +1 more source

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways [PDF]

, 2016
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and ...
Anink, Jasper J., Aronica, Eleonora, Blokhuis, Anna M., Bozzoni, Irene, Demmers, Jeroen A. A., Den Hertog, Jeroen, DINI MODIGLIANI, Stefano, Fumoto, Katsumi, Groen, Ewout J. N., Koppers, Max, Pasterkamp, R. Jeroen, Snelting, Anne, Sodaar, Peter, van Den Berg, Leonard H., van Den Heuvel, Dianne M. A., van Diggelen, Femke, Veldink, Jan H., Verheijen, Bert M.   +17 more
core   +3 more sources