Results 81 to 90 of about 29,584 (137)

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, Volume 293, Issue 8, Page 2500-2513, April 2026.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Al-Alaqatu Al-Ilmiyati Baina Al-Ulamai Al-Jawina Wa Al-Faulati Al-Usminiyyina Fi Al-Qarni Al-Sadisa Asyara Al-Miladi Ila Qarni Al-Tamina Asyara Al-Miladi

Islam Nusantara: Journal for the Study of Islamic History and Culture, 2022
Abstract For approximately five centuries, starting from 1571 and actually ending in 1924, the Ottoman Empire controlled the scientific centers in the Hejaz City. During that time, Ulama Jawi enjoyed the golden age of science. Thoriq Aziz, in his book entitled "Ulama-Ulama Nusantara yang Mempengaruhi Dunia" documented at least three Ulama from ...
openaire   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 612-617, March 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source

The S100A4 Transcriptional Inhibitor Niclosamide Reduces Pro-Inflammatory and Migratory Phenotypes of Microglia: Implications for Amyotrophic Lateral Sclerosis

Cells, 2019
S100A4, belonging to a large multifunctional S100 protein family, is a Ca2+-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types.
Alessia Serrano, Savina Apolloni, Simona Rossi, Serena Lattante, Mario Sabatelli, Mina Peric, Pavle Andjus, Fabrizio Michetti, Maria Teresa Carrì, Mauro Cozzolino, Nadia D’Ambrosi   +10 more
doaj   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis

Cells, 2019
Cytoplasmic TDP-43 aggregates are a hallmark of amyotrophic lateral sclerosis (ALS). Today, only two drugs are available for ALS treatment, and their modest effect prompts researchers to search for new therapeutic options.
Débora Lanznaster, Jérôme Bourgeais, Clement Bruno, Rudolf C. Hergesheimer, Rose-Anne Thepault, Patrick Vourc’h, Philippe Corcia, Christian R. Andres, Olivier Herault, Hélène Blasco   +9 more
doaj   +1 more source

Asalib Ta’allum al-Mu’allimy al-Dirasat al-Islamiyah Fi al-Dirasat al-‘Ulya

AJIS: Academic Journal of Islamic Studies, 2019
This study describes and identifies the learning styles of teachers who are undergoing a postgraduate course in Islamic studies. Using the quantitative descriptive method, with 27 subjects in the research subject, there is a second semester of the academic year 20018/2019 postgraduate program at Raden Rahmat Islamic University Malang, Indonesia.
Mufidah, Nuril, Kholis, Nur
openaire   +3 more sources

A, The Al-DirᾹsah Al-TahlῙliyyah Li MuhtawᾹ Al-KitᾹb Al-MadrasῙy Li Ta’lῙm Al-Lugah Al-’Arabiyyah FῙ Al-Marhalah Al-ṠᾹnawiyyah ’AlᾹ AsᾹs Cefr (Al-Iṭar Al-Marja’Ῑ Al-Aurubbiy Al-Musytarak)

Rayah Al-Islam, 2022
Knowing the level of content of Arabic textbooks at the high school level is important because it is the starting point in preparing Arabic teaching materials at the university level. Without knowing the level, repetition can occur in determining the level and cause delays in increasing the linguistic level to a higher level.
openaire   +1 more source

Al-Âyah al-Mutasyâbihât al-Lafzhiyyah fi Sûrah al-An’âm ‘Inda al-Kirmâny

Studia Quranika, 2017
This paper discusses about the verses of mutasyâbihât in the Quran. The debate of this versescaused various opinions. The meaning of the mutasyâbihât in this paper is the similarity and difference of the words in the Qur'an. Mufasir have different opinion about the meaning of the verse of mutasyâbihât al-lafdzi.
Hikmatiar Pasya, Muhammad Iqbal Rivai
openaire   +3 more sources

Comparative Study of Structural and Functional Rearrangements in Skeletal Muscle Mitochondria of SOD1-G93A Transgenic Mice at Pre-, Early-, and Late-Symptomatic Stages of ALS Progression

Frontiers in Bioscience-Landmark
Background: Amyotrophic lateral sclerosis (ALS) is a progressive multisystem disease characterized by limb and trunk muscle weakness that is attributed, in part, to abnormalities in mitochondrial ultrastructure and impaired ...
Natalia V. Belosludtseva, Anna I. Ilzorkina, Mikhail V. Dubinin, Irina B. Mikheeva, Konstantin N. Belosludtsev   +4 more
doaj   +1 more source