Results 51 to 60 of about 3,505,696 (258)
The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle
The FEBS Journal, EarlyView.DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh +2 more
wiley +1 more source
Monomelic amyotrophy: a rare variant of lower motor neuron disorder (2 clinical cases)
Анналы клинической и экспериментальной неврологии, 2017 Monomelic amyotrophy (MMA) is a rare variant of lower motorneuron disease with benign progression. The disease is characterizedby muscular weakness and atrophy in the hand and forearmon one side or asymmetrical lesion of both upper limbs with thepresence
T. M. Alekseeva +4 more
doaj +1 more source
Al Mi'yar: Jurnal Ilmiah Pembelajaran Bahasa Arab dan Kebahasaaraban, 2023 <p style="text-align: justify;"><em>This study aims to analyze the problems of Arabic learning for class VII MTS Laboratory UINSU Medan using a descriptive qualitative methodology by making eye teachers: Arabic lessons, students who were randomly selected as research subjects.
Siregar, Anni Kholilah, Taufiq, Muhammad
openaire +1 more source
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 131-143, January 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Patient Related Outcome Measures, 2020 Tina Taule,1 Margaret Søvik,2 Regina Küfner Lein,3 Eike Wehling,4,5 Jörg Aßmus,6 Tiina Rekand7,8 1Department of Occupational Therapy, Haukeland University Hospital (HUH), Bergen, Norway; 2Department of Health and Functioning ...
Taule T +5 more
doaj
Stress granules regulate paraspeckles: RNP granule continuum at work
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
doaj +1 more source
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. [PDF]
, 2017 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the
Annu, Kavya +41 more
core +2 more sources
Studia Islamika, 1970 in the past, the main purpose of IAIN was "simply" as a missionary institution, responsible for the dissemination of the Islamic religion throughout the community. However, as it developed, besides remaining as an institute for propagating missionary works, IAIN has also played an increasingly bigger role as an academic institution in the arena of ...
openaire +2 more sources
Studia Islamika, 1970 This article focuses on the role of the four lslamic reformers during the Iate 19th century and early 20th century. These four scholars include aI-Syaikh Ahmad ibn Muhammad Zayn al-Fathany (1273-1325 H/1865-1908 M); al-Syaikh al-Murabbi Muhammsd Sa'id al-Lanaqi (1292-1355 H/1875-1926 M); Tok Kenali (1287-1352 H/1870-1933 M); and al-Syaikh Thahir ...
Eeman Mohd. Abbas, Layth Suud Jasim
openaire +1 more source
Glia, Volume 74, Issue 1, January 2026.Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao +9 more
wiley +1 more source