Results 1 to 10 of about 29,855 (165)

Model for metabolic resistance against ALS inhibitors

Julius-Kühn-Archiv, 2014
Due to herbicide selection pressure metabolic resistance has evolved in many weed species. In this paper we analyse the interaction between the branched chain amino acid (BBC) pathway and detoxifying pathways for herbicide breakdown.
Richter, Otto, Langemann, Dirk, Beffa, Roland   +2 more
doaj   +2 more sources

Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2020
The Rho kinase (ROCK) inhibitor Fasudil is a promising drug for a disease-modifying therapy of amyotrophic lateral sclerosis (ALS). In preclinical models, Fasudil was shown to increase motor neuron survival, inhibit axonal degeneration, enhance axonal ...
Jan C. Koch, Josua Kuttler, Fabian Maass, Teresa Lengenfeld, Eirini Zielke, Mathias Bähr, Paul Lingor, Paul Lingor   +7 more
doaj   +3 more sources

Lisinopril activates BI1 to reprogram lipid metabolism and restore autophagy in ALS [PDF]

Communications Biology
Amyotrophic lateral sclerosis (ALS) involves disrupted lipid metabolism. Bax inhibitor 1 (BI1), an endoplasmic reticulum protein downregulated in ALS neuroprotective, represents a therapeutic target, but its metabolic regulatory mechanisms are ...
Hanlan Yin, Zhichao Ren, Yan Zhang, Yuxiang Wang, Yiyang Sun, Xueqi Fu, Wenfu Yan, Fuqiang Zhang, Linlin Zeng   +8 more
doaj   +2 more sources

Confirmation and characterisation of ALS inhibitor resistant Poa trivialis from Ireland

Pesticide Biochemistry and Physiology
Relying on one broad-spectrum product to control grass weeds has resulted in cases of resistance to acetolactate synthase (ALS) inhibitors in species that were not the primary target such as Poa trivialis (POATR), in wheat fields in Ireland. In this study, we have characterised ALS inhibitor resistance in two populations of POATR-R, suspected of being ...
Joel Torra, Hans De Jong
exaly   +4 more sources

Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS [PDF]

Frontiers in Molecular Neuroscience, 2021
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the nucleus, but ALS-linked FUS mutations can affect its nuclear localization signal impairing its import ...
Clara Tejido, Donya Pakravan, Donya Pakravan, Ludo Van Den Bosch, Ludo Van Den Bosch   +4 more
openaire   +3 more sources

Herbicide resistance prediction: a mechanistic model vs a random forest model

Julius-Kühn-Archiv, 2022
Herbicide Resistance is a major issue in weed control. Prediction tools can help to detect herbicide resistance development in early stages and enable farmers to take countermeasures. These tools can be simulation models combining population dynamics and
Lepke, Janine, Herrmann, Johannes, Beffa, Roland, Richter, Otto   +3 more
doaj   +1 more source

Bromodomain inhibitors regulate the C9ORF72 locus in ALS [PDF]

Experimental Neurology, 2015
A hexanucleotide repeat expansion residing within the C9ORF72 gene represents the most common known cause of amyotrophic lateral sclerosis (ALS) and places the disease among a growing family of repeat expansion disorders. The presence of RNA foci, repeat-associated translation products, and sequestration of RNA binding proteins suggests that toxic RNA ...
Zane, Zeier, Rustam, Esanov, Kinsley C, Belle, Claude-Henry, Volmar, Andrea L, Johnstone, Paul, Halley, Brooke A, DeRosa, Nathalie, Khoury, Marka, van Blitterswijk, Rosa, Rademakers, Jeffrey, Albert, Shaun P, Brothers, Joanne, Wuu, Derek M, Dykxhoorn, Michael, Benatar, Claes, Wahlestedt   +15 more
openaire   +2 more sources

ALS gene overexpression and enhanced metabolism conferring Digitaria sanguinalis resistance to nicosulfuron in China

Frontiers in Plant Science, 2023
Crabgrass (Digitaria sanguinalis) is a common malignant weed in corn fields in China. Recently, the acetolactate synthase (ALS) inhibitor, nicosulfuron, has shown decreasing efficacy against crabgrass.
Ruolin Wang, Ying Sun, Ying Sun, Yuning Lan, Shouhui Wei, Hongjuan Huang, Xiangju Li, Zhaofeng Huang   +7 more
doaj   +1 more source

Dosis-Wirkungs-Versuche mit Apera spica-venti (L.) in Mecklenburg-Vorpommern

Julius-Kühn-Archiv, 2020
Der Gemeine Windhalm Apera spica-venti (L.) hat sich in den zurückliegenden Jahrzehnten zu einem der wichtigsten Ungräser in Europa entwickelt. Europaweit sind für Windhalm jedoch zunehmende Resistenzfälle besonders gegenüber Herbiziden aus der Gruppe ...
Andert, Sabine, De Mol, Friederike, Jochmann, Jan, Gerowitt, Bärbel   +3 more
doaj   +1 more source

The effect of neprilysin and renin inhibition on the renal dysfunction following ischemia‐reperfusion injury in the rat

Physiological Reports, 2021
The natriuretic peptide (NP) system counter‐regulates the renin‐angiotensin system (RAS), so enhancing the activity of natriuretic peptides (NPs) may be beneficial in conditions when RAS is activated such as ischemia‐reperfusion injury (IRI).
Fayez T. Hammad, Suhail Al‐Salam, Sarah S. AlZaabi, Maryam M. Alfalasi, Awwab F. Hammad, Javed Yasin, Loay Lubbad   +6 more
doaj   +1 more source