Results 1 to 10 of about 2,287,133 (314)

Model for metabolic resistance against ALS inhibitors

Julius-Kühn-Archiv, 2014
Due to herbicide selection pressure metabolic resistance has evolved in many weed species. In this paper we analyse the interaction between the branched chain amino acid (BBC) pathway and detoxifying pathways for herbicide breakdown.
Richter, Otto, Langemann, Dirk, Beffa, Roland   +2 more
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Bisperoxovanadium promotes motor neuron survival and neuromuscular innervation in amyotrophic lateral sclerosis

Molecular Brain, 2021
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS.
Junmei Wang, Lydia Tierney, Ranjeet Mann, Thomas Lonsway, Chandler L. Walker   +4 more
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CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice

Neurobiology of Disease, 2021
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by depletion of motor neurons (MNs), for which effective medical treatments are still required.
Valentina La Cognata, Elisabetta Golini, Rosario Iemmolo, Sara Balletta, Giovanna Morello, Carla De Rosa, Ambra Villari, Sara Marinelli, Valentina Vacca, Gabriele Bonaventura, Paola Dell'Albani, Eleonora Aronica, Fabio Mammano, Silvia Mandillo, Sebastiano Cavallaro   +14 more
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Efficacy of alternative herbicides to glyphosate in the weed control in glyphosate and sulfonylurea-tolerant soybean

Acta Agronómica
It is believed that ALS inhibitor herbicides in combination with ACCase inhibitors can be used as an alternative to glyphosate in weed control in RR2/STS soybeans.
André Felipe Moreira Silva, Ana Ligia Giraldeli, Gustavo Soares da Silva, Lucas da Silva Araújo, Robson Josadaque Nogueira Lima, Diogo Alexandre Góes de Oliveira, Alfredo Junior Paiola Albrecht, Ricardo Victoria Filho   +7 more
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Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

Acta Neuropathologica Communications, 2018
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease. Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly leading to death within ~ 2–5 years of symptomatic onset. There is no cure, and
L. McGurk, J. Mojsilovic-Petrovic, V. M. Van Deerlin, J. Shorter, R. G. Kalb, V. M. Lee, J. Q. Trojanowski, E. B. Lee, N. M. Bonini   +8 more
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The occurrence of herbicide-resistant Avena fatua (wild oats) populations to ACCase-inhibiting herbicides in Ireland

Irish Journal of Agricultural and Food Research, 2021
Following growers’ reports of herbicide control problems, populations of 30 wild oats, Avena fatua, were collected from the south-east main arable counties of Ireland in 2016 and investigated for the occurrence and potential for herbicide resistance to ...
R. Byrne, A.V. Vijaya Bhaskar, J. Spink, R. Freckleton, P. Neve, S. Barth   +5 more
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GSK-3β Inhibitor Alsterpaullone Attenuates MPP+-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells

Frontiers in Cellular Neuroscience, 2018
Mitochondrial dysfunction plays significant roles in the pathogenesis of Parkinson’s Disease (PD). The inactivation of c-Myc, a down-stream gene of Wnt/β-catenin signaling, may contribute to the mitochondria dysfunction.
Jiancai Wang, Yuqian Li, Li Gao, Fengqi Yan, Guodong Gao, Lihong Li   +5 more
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Triafamone (AE 1887196) a new rice herbicide for Asia

Julius-Kühn-Archiv, 2012
Triafamone (approved ISO common name) is a new sulfonanilide herbicide discovered and developed by Bayer CropScience AG under the code number AE 1887196. Its mode of action is inhibition of the enzyme acetolactate synthase (ALS).
Sato, Yoshitaka, Hacker, Erwin, Shirakura, Shinichi, Rosinger, Christopher, Heibkes, Silke, Nakamura Shin   +5 more
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ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2019
Objectives: Disease-modifying therapies for amyotrophic lateral sclerosis (ALS) are still not satisfactory. The Rho kinase (ROCK) inhibitor fasudil has demonstrated beneficial effects in cell culture and animal models of ALS.
Paul Lingor, Paul Lingor, Markus Weber, William Camu, Tim Friede, Reinhard Hilgers, Andreas Leha, Christoph Neuwirth, René Günther, René Günther, Michael Benatar, Magdalena Kuzma-Kozakiewicz, Helen Bidner, Christiane Blankenstein, Roberto Frontini, Albert Ludolph, Jan C. Koch, The ROCK-ALS Investigators, Shahram Attarian, Mathias Bähr, Matthias Boentert, Nathalie Braun, Philippe Corcia, Isabell Cordts, Marcus Deschauer, Thorsten Grehl, Julian Grosskreutz, Andreas Hermann, Josua Kuttler, Teresa Lengenfeldt, Fabian Maass, Thomas Meyer, Susanne Petri, Yvonne Remane, Jens Schmidt, Joachim Schuster, Marie-Hélène Soriani, Jeffrey Statland, Jochen Weishaupt, Daniel Zeller, Eirini Zielke   +40 more
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Біоінформатичний аналіз потенційних ALS/AHAS-білків моркви (Daucus carota)

Фактори експериментальної еволюції організмів, 2016
Aim. One of the main challenges in plant breeding is creating of herbicide resistant cultivars and hybrids. Carrot is a very useful model plant for optimization of new plant breeding methods to create ALS-inhibitor-resistant plants due to its ...
А. В. Сидоров, В. Ю. Крат, В. А. Смірнова, Я. Ф. Парій, Ю. В. Симоненко, М. Ф. Парій   +5 more
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