Results 21 to 30 of about 2,420,347 (314)

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Nature Communications, 2018
Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo   +21 more
doaj   +1 more source

Enhanced Herbicide Metabolism and Target-Site Mutations Confer Multiple Resistance to Fomesafen and Nicosulfuron in Amaranthus retroflexus L.

Biology, 2023
Amaranthus retroflexus L. is a highly competitive broadleaf weed of corn–soybean rotation in northeastern China. In recent years, the herbicide(s) resistance evolution has been threatening its effective management in crop fields.
Cheng Yang, Hao Wang, Yunxia Duan, Feng Bei, Sisi Jia, Jinxin Wang, Hengzhi Wang, Weitang Liu   +7 more
doaj   +1 more source

ATXN2 polyQ intermediate repeats are a modifier of ALS survival [PDF]

, 2015
To analyze the frequency and clinical characteristics of patients with amyotrophic lateral sclerosis (ALS) with intermediate-length (CAG) expansion (encoding 27-33 glutamines, polyQ) in the ATXN2 gene, in a population-based cohort of Italian patients ...
Conte, Amelia, Moglia, Cristina, Lattante, Serena, Bisogni, Giulia, Moncada, Alice, Sabatelli, Mario, Marangi, Giuseppe, Canosa, A., Parals, F., Calvo, Andrea, Zollino, Marcella, Chio', Adriano   +11 more
core   +1 more source

c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.

PLoS ONE, 2012
BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive death of motor neurons. Although the pathogenesis of ALS remains unclear, several cellular processes are known to be involved, including ...
Ryu Katsumata, Shinsuke Ishigaki, Masahisa Katsuno, Kaori Kawai, Jun Sone, Zhe Huang, Hiroaki Adachi, Fumiaki Tanaka, Fumihiko Urano, Gen Sobue   +9 more
doaj   +1 more source

ING4 (inhibitor of growth family, member 4) [PDF]

, 2011
Review on ING4 (inhibitor of growth family, member 4), with data on DNA, on the protein encoded, and where the gene is ...
Miranda, C, Greco, A
core   +1 more source

Multiple mutations in the EPSPS and ALS genes of Amaranthus hybridus underlie resistance to glyphosate and ALS inhibitors [PDF]

Scientific Reports, 2020
AbstractAmaranthus hybridus is one of the main weed species in Córdoba, Argentina. Until recently, this weed was effectively controlled with recurrent use of glyphosate. However, a population exhibiting multiple resistance (MR2) to glyphosate and imazamox appeared in a glyphosate resistant (GR) soybean field, with levels of resistance up to 93 and 38 ...
Maria J. García, Candelario Palma-Bautista, José G. Vazquez-Garcia, Antonia M. Rojano-Delgado, María D. Osuna, Joel Torra, Rafael De Prado   +6 more
openaire   +3 more sources

Investigation of ammonium–lauric salt as shale swelling inhibitor and a mechanism study

Adsorption Science & Technology, 2019
In this work, a series of ammonium–lauric salts (ALS) was prepared with lauric acid and amines as small molecular shale swelling inhibitor. The inhibitors were screened by the linear expansion test first, and the result shows that the inhibitor prepared ...
Jie Zhang, Weimin Hu, Li Zhang, Tiehu Li, Dan Cai, Gang Chen   +5 more
doaj   +1 more source

Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis

Frontiers in Neurology, 2020
The Rho kinase (ROCK) inhibitor Fasudil is a promising drug for a disease-modifying therapy of amyotrophic lateral sclerosis (ALS). In preclinical models, Fasudil was shown to increase motor neuron survival, inhibit axonal degeneration, enhance axonal ...
Jan C. Koch, Josua Kuttler, Fabian Maass, Teresa Lengenfeld, Eirini Zielke, Mathias Bähr, Paul Lingor, Paul Lingor   +7 more
doaj   +1 more source

Occurrence and Mechanism of Papaver rhoeas ALS Inhibitors Resistance in Poland

Agriculture, 2022
Herbicide resistance in weeds, including corn poppy (Papaver rhoeas L.), is an increasing problem compromising global crop production. The aims of this study were to evaluate the susceptibility of P. rhoeas populations in Poland to acetolactate synthase (ALS) inhibitors and elucidate their mechanisms of resistance.
Marta Stankiewicz-Kosyl, Małgorzata Haliniarz, Mariola Wrochna, Aleksandra Obrępalska-Stęplowska, Piotr Kuc, Justyna Łukasz, Marzena Wińska-Krysiak, Barbara Wrzesińska-Krupa, Joanna Puła, Cezary Podsiadło, Krzysztof Domaradzki, Mariusz Piekarczyk, Marcin Bednarczyk, Katarzyna Marcinkowska   +13 more
openaire   +3 more sources

Edaravone: A new hope for patients with amyotrophic lateral sclerosis

Apollo Medicine, 2019
Although the exact pathophysiology of amyotrophic lateral sclerosis (ALS) remains unclear, oxidative stress is known to play a pivotal role. There is no cure for ALS, but there are two drugs available to slow the progression of the disease. Till recently,
Shivangi Garg, Dinesh Chaudhari, Pushpendra Nath Renjen, Anjali Mishra, Abhas Kumar, Rajendra Pradhan   +5 more
doaj   +1 more source