Results 11 to 20 of about 2,287,133 (314)

Herbicide resistance prediction: a mechanistic model vs a random forest model

Julius-Kühn-Archiv, 2022
Herbicide Resistance is a major issue in weed control. Prediction tools can help to detect herbicide resistance development in early stages and enable farmers to take countermeasures. These tools can be simulation models combining population dynamics and
Lepke, Janine, Herrmann, Johannes, Beffa, Roland, Richter, Otto   +3 more
doaj   +1 more source

Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS [PDF]

Frontiers in Molecular Neuroscience, 2021
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the nucleus, but ALS-linked FUS mutations can affect its nuclear localization signal impairing its import ...
Clara Tejido, Donya Pakravan, Donya Pakravan, Ludo Van Den Bosch, Ludo Van Den Bosch   +4 more
openaire   +3 more sources

Bromodomain inhibitors regulate the C9ORF72 locus in ALS [PDF]

Experimental Neurology, 2015
A hexanucleotide repeat expansion residing within the C9ORF72 gene represents the most common known cause of amyotrophic lateral sclerosis (ALS) and places the disease among a growing family of repeat expansion disorders. The presence of RNA foci, repeat-associated translation products, and sequestration of RNA binding proteins suggests that toxic RNA ...
Zane, Zeier, Rustam, Esanov, Kinsley C, Belle, Claude-Henry, Volmar, Andrea L, Johnstone, Paul, Halley, Brooke A, DeRosa, Nathalie, Khoury, Marka, van Blitterswijk, Rosa, Rademakers, Jeffrey, Albert, Shaun P, Brothers, Joanne, Wuu, Derek M, Dykxhoorn, Michael, Benatar, Claes, Wahlestedt   +15 more
openaire   +2 more sources

A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS [PDF]

, 2022
Dual leucine zipper kinase (DLK), which regulates the c-Jun N-terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS).
Oskarsson, Björn, Leonard van den Berg, Khema R. Sharma, Cudkowicz, Merit E, Brooks, Logan, Jonathan S. Katz, Geoffrey A. Kerchner, Flavia Brunstein, Merit E. Cudkowicz, van den Berg, Leonard, Glass, Jonathan D, Jeffrey D. Rothstein, Angela Genge, Braydon L. Burgess, Rothenberg, Michael E, Berry, James D, Katz, Jonathan S, Ghosh, Arundhati Sengupta, Yeh, Felix L, Brunstein, Flavia, Jessica A. Couch, Chen, Chen, Arundhati Sengupta Ghosh, Björn Oskarsson, Genge, Angela, Logan Brooks, Burgess, Braydon L, Cho, William, Avis B. Hains, Rothstein, Jeffrey D, Kerchner, Geoffrey A, Chen Chen, Jonathan D. Glass, Sravanthi Cheeti, Lee Honigberg, Honigberg, Lee, Couch, Jessica A, William Cho, Galanter, Joshua, Cheeti, Sravanthi, Felix L. Yeh, Joshua Galanter, Michael E. Rothenberg, James D. Berry, Hains, Avis B, Sharma, Khema R   +45 more
core   +1 more source

ALS gene overexpression and enhanced metabolism conferring Digitaria sanguinalis resistance to nicosulfuron in China

Frontiers in Plant Science, 2023
Crabgrass (Digitaria sanguinalis) is a common malignant weed in corn fields in China. Recently, the acetolactate synthase (ALS) inhibitor, nicosulfuron, has shown decreasing efficacy against crabgrass.
Ruolin Wang, Ying Sun, Ying Sun, Yuning Lan, Shouhui Wei, Hongjuan Huang, Xiangju Li, Zhaofeng Huang   +7 more
doaj   +1 more source

Dosis-Wirkungs-Versuche mit Apera spica-venti (L.) in Mecklenburg-Vorpommern

Julius-Kühn-Archiv, 2020
Der Gemeine Windhalm Apera spica-venti (L.) hat sich in den zurückliegenden Jahrzehnten zu einem der wichtigsten Ungräser in Europa entwickelt. Europaweit sind für Windhalm jedoch zunehmende Resistenzfälle besonders gegenüber Herbiziden aus der Gruppe ...
Andert, Sabine, De Mol, Friederike, Jochmann, Jan, Gerowitt, Bärbel   +3 more
doaj   +1 more source

The effect of neprilysin and renin inhibition on the renal dysfunction following ischemia‐reperfusion injury in the rat

Physiological Reports, 2021
The natriuretic peptide (NP) system counter‐regulates the renin‐angiotensin system (RAS), so enhancing the activity of natriuretic peptides (NPs) may be beneficial in conditions when RAS is activated such as ischemia‐reperfusion injury (IRI).
Fayez T. Hammad, Suhail Al‐Salam, Sarah S. AlZaabi, Maryam M. Alfalasi, Awwab F. Hammad, Javed Yasin, Loay Lubbad   +6 more
doaj   +1 more source

Herbicide Resistance Status of Italian Ryegrass (Lolium multiflorum Lam.) and Alternative Herbicide Options for Its Effective Control in the Huang-Huai-Hai Plain of China

Agronomy, 2022
Italian ryegrass (Lolium multiflorum Lam.) was introduced into China as a kind of turfgrass and has invaded wheat fields of the Huang-Huai-Hai Plain, causing great losses to grain yield.
Wei Li, Cuixia Wu, Mali Wang, Minghao Jiang, Jingxu Zhang, Min Liao, Haiqun Cao, Ning Zhao   +7 more
doaj   +1 more source

Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling

Brain Research Bulletin, 2023
Background: ANO1 is closely correlated with the activation of EGFR and CaMKII, while EGFR and CaMKII show low activation in amyotrophic lateral sclerosis (ALS) models.
Ying Wang, Weiwei Liang, Tianhang Wang, Chunting Zhang, Yueqing Yang, Chaohua Cong, Xudong Wang, Shuyu Wang, Di Wang, Di Huo, Hongyong Wang, Xiaoli Su, Xingli Tan, Honglin Feng   +13 more
doaj   +1 more source

Detecting herbicide-resistant Apera spica-venti with a chlorophyll fluorescence agar test

Plant, Soil and Environment, 2018
Reliable tests on herbicide resistance are important for resistance management. Despite well-established greenhouse bioassays, faster and in-season screening methods would aid in more efficient resistance detection.
Alexander Ingo LINN, Pavlína KOŠNAROVÁ, Josef SOUKUP, Roland GERHARDS   +3 more
doaj   +1 more source