Results 31 to 40 of about 2,420,347 (314)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Proteasome Inhibitors to Treat AL Amyloidosis

, 2016
Amyloidoses represent a highly heterogeneous group of diseases characterized by the abnormal production and accumulation of abnormal, insoluble amyloid proteins in various tissues leading to organ dysfunction. Light‐chain (AL) amyloidosis is the most common form of systemic amyloidosis and is characterized by extracellular deposi‐ tion of pathologic ...
James J. Driscoll, Saulius Girnius
openaire   +2 more sources

Rapid detection of acetolactate synthase inhibitor–resistant weeds using novel full-spectrum imaging and a hyperparameter-tuned convolutional neural network

Weed Technology
Herbicide-resistant weeds are fast becoming a substantial global problem, causing significant crop losses and food insecurity. Late detection of resistant weeds leads to increasing economic losses.
Pauline Victoria Estrada, John Benedict Estrada, Jennifer Valdez-Herrera, Anil Shrestha   +3 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

N-acetyl-l-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model

Neurobiology of Disease, 2015
Background: Whether l-NAT, a cytochrome c release inhibitor and an antagonist of NK-1R, provides protection in ALS is not known. Results: l-NAT delays disease onset and mortality in mSOD1G93A ALS mice by inhibiting mitochondrial cell death pathways ...
Wei Li, Anastasios Fotinos, Qiaofeng Wu, Yanchun Chen, Yongjin Zhu, Sergei Baranov, Yanyang Tu, Edward W. Zhou, Bharati Sinha, Bruce S. Kristal, Xin Wang   +10 more
doaj   +1 more source

Bisperoxovanadium promotes motor neuron survival and neuromuscular innervation in amyotrophic lateral sclerosis

Molecular Brain, 2021
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS.
Junmei Wang, Lydia Tierney, Ranjeet Mann, Thomas Lonsway, Chandler L. Walker   +4 more
doaj   +1 more source

CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice

Neurobiology of Disease, 2021
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by depletion of motor neurons (MNs), for which effective medical treatments are still required.
Valentina La Cognata, Elisabetta Golini, Rosario Iemmolo, Sara Balletta, Giovanna Morello, Carla De Rosa, Ambra Villari, Sara Marinelli, Valentina Vacca, Gabriele Bonaventura, Paola Dell'Albani, Eleonora Aronica, Fabio Mammano, Silvia Mandillo, Sebastiano Cavallaro   +14 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS

, 2022
The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 variants in untranslated regions of 6,
Project MinE ALS Sequencing Consortium
core  

A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial [PDF]

, 2023
Background: Amyotrophic lateral sclerosis (ALS) is a highly debilitating neurodegenerative condition. Despite recent advancements in understanding the molecular mechanisms underlying ALS, there have been no significant improvements in therapeutic options
Puopolo, Maria, Lo Giudice, Maria, Van Damme, Philip, Alegiani, Stefania Spila, Corcia, Philippe, Mayer, Flavia, Ludolph, Albert Christian, McDermott, Christopher J., TUDCA-ALS Study Group, Albanese, Alberto, Cipriani, Marta, Dickie, Brian, Van den Berg, Leonard H., Nicolini, Gabriele, Lombardo, Flavia L., Vanacore, Nicola, Hardiman, Orla   +16 more
core