Results 261 to 270 of about 129,945 (312)

The design and synthesis of ALS inhibitors from pharmacophore models

Bioorganic & Medicinal Chemistry Letters, 1999
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
J, Liu, Z, Li, H, Yan, L, Wang, J, Chen
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A novel Pro197Glu substitution in acetolactate synthase (ALS) confers broad-spectrum resistance across ALS inhibitors

Pesticide Biochemistry and Physiology, 2015
Water chickweed (Myosoton aquaticum L.), a competitive broadleaf weed, is widespread in wheat fields in China. Tribenuron and pyroxsulam failed to control water chickweed in the same field in Qiaotian Village in 2011 and 2012, respectively. An initial tribenuron resistance confirmation test identified a resistant population (AH02).
Weitang, Liu, Guohui, Yuan, Long, Du, Wenlei, Guo, Lingxu, Li, Yaling, Bi, Jinxin, Wang   +6 more
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Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats

Metabolism, 1987
Two new potent aldose reductase inhibitors, AL-1567 (DL-spiro(2-fluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione) and AL-1576 (spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)2',5'-dione), have been characterized with respect to in vitro activity toward rat lens and human placental aldose reductase and in vivo activity in uncontrolled, severely ...
B W, Griffin, L G, McNatt, M L, Chandler, B M, York   +3 more
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Targeting FUS-ALS aggregation with Proteasome Inhibitors

SummaryALS, Amyotrophic lateral sclerosis, a devastating neurodegenerative disease (ND) with no cure, is often caused by abnormal cytosolic aggregation of RNA-binding proteins, the most well-known of which are TDP-43 and FUS. The proteasome is considered one of the major systems that degrades misfolded, including ND-associated, proteins, thereby acting
Amal Younis, Kanar Yassen, Kinneret Rozales, Tahani Kadah, Naseeb Saida, Anatoly Meller, Joyeeta Dutta Hazra, Ronit Heinrich, Flonia Levy-Adam, Shai Berlin, Reut Shalgi   +10 more
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TATI (Tumor Associated Trypsin Inhibitor) als Tumormarker beim Ovarialkarzinom

Archives of Gynecology and Obstetrics, 1993
TATI stellt mit einer Sensitivitat von 67% und einer Spezifitat von 69% keinen Ersatz fur CA 125 als Tumormarker dar, ist jedoch vor allem in Kombination mit CA 125 eine wertvolle Erganzung in der Diagnostik (negative Korrektheit: 90,5%) und im Monitoring des Ovars.
M. Medl, E. Ogris, S. Loedolter
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Hesperidinphosphat als Hyaluronidaseinhibitor

Klinische Wochenschrift, 1954
Mit Hilfe der Cantharidenblasenmethode und der Capillarresistometrie ist es moglich, den Effekt des Hesperidinphosphats auf die Eiweis- und Erythrocytendurchlassigkeit der Capillarwandschranke statistisch wahrscheinlich zu machen.
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Research Progress of ALS and ALS Inhibitors Herbicides

Botanical Research, 2021
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PARP-Inhibitor wirksamer als Chemo?

InFo Hämatologie + Onkologie, 2022
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Ovarialkarzinom: PARP-Inhibitor wirksamer als Chemotherapie?

gynäkologie + geburtshilfe, 2022
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PARP-Inhibitor plus NHT als Option

InFo Hämatologie + Onkologie, 2023
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