Results 241 to 250 of about 30,176 (297)

G-Quadruplexes Abet Neuronal Burnout in ALS and FTD. [PDF]

Antioxidants (Basel)
Herbert A.
europepmc   +1 more source

Brain organoids as precision models for neurodegenerative diseases: from disease modeling to drug discovery. [PDF]

Front Neurosci
Zheng Y, Zhou W, Chang H, Zheng K.
europepmc   +1 more source

The Bright and Dark Sides of Nitric Oxide in Neurodegenerative Diseases. [PDF]

J Pers Med
Buccarello L, Montagna C, Di Matteo S, Mangione R, Carota G, Sibbitts J, Jarosova R, Lunte SM, Lazzarino G, Caruso G.   +9 more
europepmc   +1 more source

Deciphering the Neuroautophagic Interactome: Molecular Circuits Linking Selective Autophagy to Neuropathological Cascades in Neurological Disorders. [PDF]

Int J Biol Sci
Luo P, Travis ZD, Lenahan C, Wu H, Zhang J, Yu J, Xu W.   +6 more
europepmc   +1 more source

VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. [PDF]

Acta Neuropathol Commun
Tripathi P, Guo H, Yamoah A, Mathur R, Doukas P, Dreser A, Jesse CM, Aronica E, Hermann A, Steinbusch H, Brook GA, Weis J, Goswami A.   +12 more
europepmc   +1 more source

Correction to “Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors”

Molecular Oncology, EarlyView.
wiley   +1 more source

EXPRESSION OF CONCERN: DIMP53‐1: A Novel Small‐Molecule Dual Inhibitor of p53–MDM2/X Interactions with Multifunctional p53‐Dependent Anticancer Properties

Molecular Oncology, EarlyView.
wiley   +1 more source

EXPRESSION OF CONCERN: A Newly Identified 45‐kDa JAK2 Variant with an Altered Kinase Domain Structure Represents a Novel Mode of JAK2 Kinase Inhibitor Resistance

Molecular Oncology, EarlyView.
wiley   +1 more source

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The design and synthesis of ALS inhibitors from pharmacophore models

Bioorganic and Medicinal Chemistry Letters, 1999
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
J, Liu, Z, Li, H, Yan, L, Wang, J, Chen
exaly   +3 more sources