Results 251 to 260 of about 112,765 (306)

Liquid nitrogen as an adjuvant to ALS-inhibitors

, 2019
openaire   +1 more source

The Other Side of the Same Coin: Beyond the Coding Region in Amyotrophic Lateral Sclerosis. [PDF]

Pharmaceuticals (Basel)
Ruffo P, Perrone B, Perrone F, De Amicis F, Iuliano R, Bucci C, Messina A, Conforti FL.   +7 more
europepmc   +1 more source

[New results from the RABBIT register on the cancer risk of patients with rheumatoid arthritis treated with Janus kinase inhibitors]. [PDF]

Z Rheumatol
Schäfer M, Strangfeld A.
europepmc   +1 more source

Insights into ALS-inhibiting herbicide resistance in Poa annua in an arable cropping system. [PDF]

Pest Manag Sci
Vijaya Bhaskar AV, Vijayakumar I, Torra J, Runge F, Hennessy M, Forristal PD.   +5 more
europepmc   +1 more source

Does Amyotrophic Lateral Sclerosis (ALS) Have Metabolic Causes from Human Evolution? [PDF]

Cells
Spedding M.
europepmc   +1 more source

Correction to “Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors”

Molecular Oncology, EarlyView.
wiley   +1 more source

Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS [PDF]

Frontiers in Molecular Neuroscience, 2021
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly in the nucleus, but ALS-linked FUS mutations can affect its nuclear localization signal impairing its import ...
Clara Tejido, Donya Pakravan, Ludo Van Den Bosch   +2 more
exaly   +4 more sources

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Aggregation of trypsin and trypsin inhibitor by Al cation

Journal of Photochemistry and Photobiology B: Biology, 2017
Al cation may trigger protein structural changes such as aggregation and fibrillation, causing neurodegenerative diseases. We report the effect of Al cation on the solution structures of trypsin (try) and trypsin inhibitor (tryi), using thermodynamic analysis, UV-Visible, Fourier transform infrared (FTIR) spectroscopic methods and atomic force ...
P, Chanphai, L, Kreplak, H A, Tajmir-Riahi   +2 more
openaire   +2 more sources

The design and synthesis of ALS inhibitors from pharmacophore models

Bioorganic and Medicinal Chemistry Letters, 1999
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
Zhengming Li
exaly   +3 more sources