Results 81 to 90 of about 112,092 (264)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Study on the Efficacy of Some Current Herbicides for Control of Resistant and Susceptible Canarygrass (Phalaris spp.) Biotypes to Acetyl CoA Carboxylase (ACCase) Inhibitors

پژوهشهای زراعی ایران, 2011
Two separate greenhouse experiments were conducted in the greenhouse facilities of the Iranian Plant Protection Research Institute, Tehran, to study the efficacy of some herbicides to control of resistant and susceptible P. minor and P. paradoxa biotypes.
e Zand, M. Baghestani, M Pourbaige, s Soufizadeh, F Bena Kashani, f Dastaran, mm Khayami, m Labbafi Hosseinabadi   +7 more
doaj   +1 more source

Differential sensitivity of locally naturalized Panicum species to HPPD- and ALS-inhibiting herbicides [PDF]

, 2014
Panicum schinzii (Transvaal millet), P. dichotomiflorum (Fall panicum) and P. capillare (Witchgrass) are alien panicoid grasses that have gradually spread and are now locally naturalized in corn fields in Belgium.
Bulcke, Robert, Claerhout, Sofie, De Cauwer, Benny, Geeroms, Tim, Reheul, Dirk   +4 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Target-site and non-target-site resistance mechanisms to ALS inhibiting herbicides in Papaver rhoeas [PDF]

, 2017
Target-site and non-target-site resistance mechanisms to ALS inhibitors were investigated in multiple resistant (tribenuron-methyl and 2,4-D) and only 2,4-D resistant, Spanish corn poppy populations.
Menéndez, Julio, Osuna, Maria D., Rey Caballero, Jordi, Salas, Marisa, Torra Farré, Joel   +4 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Regional diversity of the ALS gene and hormesis due to tribenuron-methyl in Centaurea cyanus L.

Scientific Reports
Centaurea cyanus L. is a common field weed in Eastern Europe but only in Poland biotypes of this species with resistance to acetolactate synthase (ALS) inhibitors have been confirmed.
Marta Stankiewicz-Kosyl, Marzena Wińska-Krysiak, Mariola Wrochna, Małgorzata Haliniarz, Katarzyna Marcinkowska   +4 more
doaj   +1 more source

Backbone switch to abacavir/lamivudine fixed-dose combination: implications for antiretroviral therapy optimization [PDF]

, 2015
Current guidelines recommend treatment optimization in virologically suppressed patients through switching/ simplification strategies to minimize long-term toxicities and improve adherence. The assessment of inflammation/ coagulation profiles may support
FALASCA, FRANCESCA, FANTAUZZI, Alessandra, Floridia, Marco, MEZZAROMA, Ivano, SPANEDDA, Pierpaolo, TURRIZIANI, Ombretta, VULLO, Vincenzo   +6 more
core  

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction [PDF]

, 2019
p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their ...
Long, David T., Rycenga, Halley B., Wolfe, Kelly B., Yeh, Elizabeth S.   +3 more
core   +1 more source