Results 81 to 90 of about 5,859 (181)

A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 4, Page 270-290, June 2026.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

Associations Between Big-5 Personality Traits, Cognitive Ability, and Climate Beliefs and Behaviours: Results From a Longitudinal UK Birth Cohort

Europe's Journal of Psychology
Anthropogenic climate change is an existential threat to both humans and wider biodiversity. However, cumulatively, individuals’ actions can help to mitigate the impacts of climate change.
Ken Freminot, Katie Major-Smith, Kate Northstone, Isaac Halstead, Daniel Major-Smith   +4 more
doaj   +1 more source

Releasing synthetic data from the Avon Longitudinal Study of Parents and Children (ALSPAC): Guidelines and applied examples [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective birth cohort. Since its inception in the early 1990s, the study has collected over thirty years of data on approximately 15,000 mothers, their partners, and their offspring ...
Nicholas J. Timpson, Kate Northstone, Jon Heron, Daniel Major-Smith, Alex S. F. Kwong   +4 more
doaj   +1 more source

The ethics conundrum in Recall by Genotype (RbG) research: Perspectives from birth cohort participants.

PLoS ONE, 2018
PurposeRecall by genotype (RbG) research recruits on the basis of genetic variation. Increased use of this approach presents an ethical conundrum for cohort studies/biobanks: whether to inform individuals of their genetic information and deviate from ...
Joel T Minion, Frances Butcher, Nicholas Timpson, Madeleine J Murtagh   +3 more
doaj   +1 more source

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study.

PLoS Medicine, 2017
BackgroundIt has been suggested that greater maternal adiposity during pregnancy affects lifelong risk of offspring fatness via intrauterine mechanisms.
Rebecca C Richmond, Nicholas J Timpson, Janine F Felix, Tom Palmer, Romy Gaillard, George McMahon, George Davey Smith, Vincent W Jaddoe, Debbie A Lawlor   +8 more
doaj   +1 more source

Adverse childhood experiences in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC) [version 1; referees: 3 approved]

Wellcome Open Research, 2018
Background: Exposure to adverse childhood experiences (ACEs) is a risk factor for poor later life health. Here, we describe the ACE variables measured in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC) study, and a method ...
Lotte C. Houtepen, Jon Heron, Matthew J. Suderman, Kate Tilling, Laura D. Howe   +4 more
doaj   +1 more source

Estimating age of menopause in mothers in the ALSPAC Study: A data note

Wellcome Open Research
Earlier menopause is associated with increased risks of type 2 diabetes, osteoporosis, heart disease, depression, and mortality. Although menopause is typically defined as the absence of menstruation for 12 consecutive months, estimating age of menopause using repeated, prospective data can be challenging.
Rochelle Knight, Abigail Fraser, Carol Joinson, Ana Goncalves Soares   +3 more
openaire   +2 more sources

The Avon Longitudinal Study of Parents and Children (ALSPAC): a resource for genetic epidemiology [PDF]

European Journal of Endocrinology, 2004
The Avon Longitudinal Study of Parents and Children (ALSPAC) has collected detailed phenotypic and environmental information from pregnancy onwards on approximately 14 000 babies born in 1991-1992. A DNA bank on over 10 000 mothers and children has been established with generic consent for (undisclosed) genetic analysis, and cell lines on both children
openaire   +2 more sources

The destruction of the ‘Windrush’ disembarkation cards: a lost opportunity and the (re)emergence of Data Protection regulation as a threat to longitudinal research [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Historical records and the research databases of completed studies have the potential either to establish new research studies or to inform follow-up studies assessing long-term health and social outcomes.
Andy Boyd, Matthew Woollard, John Macleod, Alison Park   +3 more
doaj   +1 more source

ALSPAC Mercury Study and Fish Consumers: Golding et al. Respond

Environmental Health Perspectives, 2014
We apologize if our article (Golding et al. 2013) was unclear in some respects. We would like to respond to the comments of Gochfeld et al. and clarify some points in our article. Contrary to the claims by Gochfeld et al., the Avon Longitudinal Study of Parents and Children (ALSPAC) study was designed to investigate the effects of various prenatal ...
Golding, Jean, Steer, Colin D., Lowery, Tony, Hibbeln, Joseph R.   +3 more
openaire   +2 more sources