Results 71 to 80 of about 6,088 (178)

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

Human Genomics, 2019
Background Mitochondrial DNA copy number (mtDNA CN) exhibits interindividual and intercellular variation, but few genome-wide association studies (GWAS) of directly assayed mtDNA CN exist.
Anna L. Guyatt, Rebecca R. Brennan, Kimberley Burrows, Philip A. I. Guthrie, Raimondo Ascione, Susan M. Ring, Tom R. Gaunt, Angela Pyle, Heather J. Cordell, Debbie A. Lawlor, Patrick F. Chinnery, Gavin Hudson, Santiago Rodriguez   +12 more
doaj   +1 more source

Is adolescent multiple risk behaviour associated with reduced socioeconomic status in young adulthood and do those with low socioeconomic backgrounds experience greater negative impact? Findings from two UK birth cohort studies

BMC Public Health, 2021
Background Adolescent multiple risk behaviour (MRB) is associated with negative outcomes such as police arrests, unemployment and premature mortality and morbidity. What is unknown is whether MRB is associated with socioeconomic status (SES) in adulthood.
Laura Tinner, Caroline Wright, Jon Heron, Deborah Caldwell, Rona Campbell, Matthew Hickman   +5 more
doaj   +1 more source

What Endocrinologists Should Know About Iodine: Population Deficiency, Individual Excess and Misinformation in the United Kingdom

Clinical Endocrinology, Volume 105, Issue 5, Page 523-530, November 2026.
ABSTRACT Iodine deficiency, once considered eliminated in the United Kingdom, has re‐emerged, particularly among women of reproductive age, in whom requirements are increased during pregnancy and lactation. The declining consumption of dairy and white fish, the emerging use of unfortified plant‐based milk alternatives, and the absence of a national ...
Peter N. Taylor, Malcolm Prentice, Sarah Bath, Emilie Combet, Nadia Schoenmakers, Vicki E. Smith, Fraser W. Gibb, Nicola Zammitt, Onyebuchi Okosieme, Kristien Boelaert, John Lazarus, Mark Vanderpump   +11 more
wiley   +1 more source

Childhood internalising symptoms at ages 3 and 6: a meta‐analysis of epigenome‐wide associations from cord and peripheral blood

Journal of Child Psychology and Psychiatry, Volume 67, Issue 11, Page 1868-1882, November 2026.
Background Pre‐ and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems.
Laura Schellhas, Mannan Luo, Janine F. Felix, Christian M. Page, Mona Bekkhus, Marcus R. Munafò, Luisa Zuccolo, Alexandra Havdahl, Charlotte A.M. Cecil, Gemma C. Sharp   +9 more
wiley   +1 more source

Investigating Learning, Decision-Making, and Mental Health in Pregnancy: Insights From a UK Cohort Study

Computational Psychiatry
Background: Parental capacity to learn from infant responses is a fundamental component of early dyadic interactions. However, the precise cognitive processes involved in these interactions and how these processes are influenced by mental health ...
Ilaria Costantini, Axel Montout, Paul Moran, Daphne Kounali, Rebecca M. Pearson, Casimir J. H. Ludwig   +5 more
doaj   +1 more source

Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation

Autism Research, Volume 19, Issue 10, October 2026.
ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD).
Michelle Pearl, Kimberly Berger, Piera M. Cirillo, Nickilou Y. Krigbaum, Victor Poon, Gayle C. Windham, Barbara A. Cohn   +6 more
wiley   +1 more source

Maternal glycaemia and child educational attainment at age 5 in the Born in Bradford cohort

Diabetic Medicine, Volume 43, Issue 10, October 2026.
Abstract Aims There is emerging evidence that maternal hyperglycaemia may be associated with adverse offspring neuro‐behavioural outcomes, which are foundational to educational success. We hypothesised that higher levels of maternal glucose would be associated with poorer educational attainment in early childhood.
Claire A. Wilson, Gillian Santorelli, Emily Simonoff, Louise M. Howard, Khalida Ismail, Rebecca M. Reynolds   +5 more
wiley   +1 more source

Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort

JCPP Advances, Volume 6, Issue 3, September 2026.
Abstract Background There are substantial age‐related changes in emotional and behavioural problems over childhood. In order to establish the impact of the Covid‐19 pandemic on child emotional and behavioural problems, longitudinal designs which take into account age‐related trends are needed.
Nicky Wright, Daphne Kounali, Elise Paul, Alex S. F. Kwong, Daniel Major‐Smith, Ilaria Costantini, Deborah A. Lawlor, Kapil Sayal, Helen Bould, Nicholas J. Timpson, Kate Northstone, Melanie Lewcock, Kate Tilling, Rebecca M. Pearson   +13 more
wiley   +1 more source

Associations Between Big-5 Personality Traits, Cognitive Ability, and Climate Beliefs and Behaviours: Results From a Longitudinal UK Birth Cohort

Europe's Journal of Psychology
Anthropogenic climate change is an existential threat to both humans and wider biodiversity. However, cumulatively, individuals’ actions can help to mitigate the impacts of climate change.
Ken Freminot, Katie Major-Smith, Kate Northstone, Isaac Halstead, Daniel Major-Smith   +4 more
doaj   +1 more source

Factors associated with better emotional, behavioural and educational outcomes in children with mild intellectual difficulties

JCPP Advances, Volume 6, Issue 3, September 2026.
Abstract Background Children with mild intellectual difficulties (MID) are at increased risk of poor mental health and functional outcomes compared to typically developing children. Previous research has primarily focused on deficit‐based comparisons. However, substantial heterogeneity exists in this population, ranging from significant impairment to ...
Foteini Tseliou, Charlotte A. Dennison, Christopher B. Eaton, Jessica M. Armitage, Frances Rice, Stephan Collishaw   +5 more
wiley   +1 more source