Results 51 to 60 of about 6,088 (178)

Advancing Artificial Intelligence in Myopia Management: From Predicting Progression to Supporting Clinical Decisions

Med Research, EarlyView.
The AI‐enabled multimodal framework for whole‐life myopia management. Graphical abstract illustrates the transition of myopia care from premyopia to myopia, high myopia, and pathologic myopia. Multimodal data, including demographic and refractive information, genetic, behavioral and environmental factors, ophthalmic imaging, and omics profiles, can be ...
Zewei Zhang, Yun Wang, Lifei Zhang, Dongmei Chen, Weijie Zhang, Fang Li, Jibo Zhou   +6 more
wiley   +1 more source

Polygenic prediction of cannabis‐related outcomes: Evidence from the Avon Longitudinal Study of Parents and Children longitudinal cohort and the European gene–environment interaction case–control study

Addiction, EarlyView.
Abstract Background and aims Polygenic risk scores (PRSs) for cannabis use disorder (CUD), major depressive disorder (MDD), insomnia and chronic pain, and early age at cannabis initiation might be linked to problematic cannabis use. We tested whether: (1) higher PRS for CUD, MDD, insomnia and chronic pain are associated with earlier initiation and ...
Edoardo Spinazzola, Isabelle Austin‐Zimmerman, Giulia Trotta, Zhikun Li, Perry B. M. Leung, Edward Chesney, Qiang Li, Luis Alameda, Celso Arango, Michael O'Donovan, Jim van Os, Pak C. Sham, Craig Morgan, Evangelos Vassos, Diego Quattrone, Tom Freeman, Marta Di Forti, Robin M. Murray   +17 more
wiley   +1 more source

Highs and lows: Complex relationships between childhood socio‐economic position and adolescent substance use in three United Kingdom birth cohorts

Addiction, EarlyView.
Abstract Background and aims Substance use behaviours frequently commence in adolescence, and socio‐economic position (SEP) in childhood is a key predictor of variation in adolescent substance use behaviours; however, the relationship between SEP and substance use may be changing over time.
Caitlyn Rawers, Orla McBride, Jamie Murphy, Eoin McElroy   +3 more
wiley   +1 more source

The ALSPAC Coordination Test (subtests of the Movement ABC): Methodology and data on associations with prenatal exposures to lead, cadmium and mercury

Data in Brief, 2018
As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of child motor skills were collected in research clinics. The ALSPAC Coordination Test was derived from subtests of the Movement ABC at age 7 years in children ...
Caroline M. Taylor, Alan M. Emond, Raghu Lingam, Jean Golding   +3 more
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Synthetic ALSPAC longitudinal datasets for the Big Data VR project

Wellcome Open Research, 2017
Three synthetic datasets - of observation size 15,000, 155,000 and 1,555,000 participants, respectively - were created by simulating eleven cardiac and anthropometric variables from nine collection ages of the ALSAPC birth cohort study. The synthetic datasets retain similar data properties to the ALSPAC study data they are simulated from (co-variance ...
Demetris Avraam, Rebecca C. Wilson, Paul Burton   +2 more
openaire   +3 more sources

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

Epigenetics, 2019
Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic health in offspring. Epigenetic alterations, such as in DNA methylation (DNAm), are a hypothesized link; however, sex-specific epigenomic targets remain unclear.
Chantel L. Martin, Dereje Jima, Gemma C. Sharp, Lauren E. McCullough, Sarah S. Park, Kymberly M. Gowdy, David Skaar, Michael Cowley, Rachel L. Maguire, Bernard Fuemmeler, David Collier, Caroline L. Relton, Susan K. Murphy, Cathrine Hoyo   +13 more
doaj   +1 more source

Examining the longitudinal nature of depressive symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC) [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Depression during adolescence is associated with a number of negative outcomes in later life. Research has examined the longitudinal nature of adolescent depression in order to identify patterns of depressive mood, the early antecedents and later ...
Alex S. F. Kwong
doaj   +1 more source

Depressive symptoms measured using the Edinburgh Postnatal Depression Scale in mothers and partners in the ALSPAC Study: A data note [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Depression is a leading cause of disability and is associated with a number of adverse offspring outcomes when it occurs in parents. Depression is present in men and women at different rates, and recent research suggests that symptom profiles between the
Elise Paul, Rebecca M. Pearson
doaj   +1 more source

Early‐life pathways to inequalities in child mental health: evidence from eight birth cohorts

Journal of Child Psychology and Psychiatry, EarlyView.
Background Socioeconomic inequalities in children's emotional and behavioural problems are already present at school entry. We examined associations between early‐life socioeconomic conditions and children's externalising and internalising problems and assessed whether early‐life risk factors mediated these associations.
Demetris Avraam, Gabriella Melis, Tim Cadman, Jennie Carson, Marie Aline Charles, Yu Wei Chua, Ahmed Elhakeem, Joaquín Escribano, Veit Grote, Dariusz Gruszfeld, Kathrin Guerlich, Rae‐Chi Huang, Jennifer R. Harris, Jesus Ibarluzea, Jordi Julvez, Berthold Koletzko, Ashleigh Lin, Unai Martin, Rosemary McEachan, Maria Melchior, Phillip Melton, Johanna Thorbjornsrud Nader, Angela Pinot de Moira, Maja Popovic, Simona Porru, Lorenzo Richiardi, Blanca Sarzo, Daniela Schlüter, Jordi Sunyer, Morris Swertz, Elvira Verduci, John Wright, Annick Xhonneux, Tiffany Yang, Daniela Zugna, Anne‐Marie Nybo Andersen, Katrine Strandberg‐Larsen, David Taylor‐Robinson   +37 more
wiley   +1 more source