Results 11 to 20 of about 28,483 (297)

Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up? [PDF]

Western Journal of Emergency Medicine, 2020
Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as ...
Tony Zitek, Ramsey Ataya, Isabel Brea
doaj   +3 more sources

Tenecteplase versus Alteplase [PDF]

InFo Neurologie & Psychiatrie, 2017
openaire   +3 more sources

Low-dose vs. standard-dose alteplase for Chinese patients with acute ischemic stroke: A propensity score analysis

Frontiers in Neurology, 2023
Background and purposePrevious studies have stimulated debates on low-dose alteplase administration in acute ischemic stroke (AIS) among the Asian population.
Jiawen Xu, Xi Chen, Yanan Xie, Yi Wang, Shidong Chen, Qiang Dong, Yi Dong, Kun Fang   +7 more
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Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance It is estimated that only 27% of patients with acute ischemic stroke and large vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are disability free at 90 days.
A. Renú, M. Millán, L. San Román, J. Blasco, J. Martí-Fábregas, M. Terceño, S. Amaro, J. Serena, X. Urra, C. Laredo, R. Barranco, P. Camps-Renom, F. Zarco, L. Oleaga, P. Cardona, C. Castaño, J. Macho, E. Cuadrado-Godia, E. Vivas, A. López-Rueda, L. Guimaraens, A. Ramos-Pachón, J. Roquer, M. Muchada, A. Tomasello, A. Dávalos, Ferran Torres, Á. Chamorro   +27 more
semanticscholar   +1 more source

Outcomes and Treatment Complications of Intravenous Urokinase Thrombolysis in Acute Ischemic Stroke in China

Frontiers in Neurology, 2021
Background: Intravenous thrombolysis with alteplase benefits eligible patients with acute ischemic stroke. However, in some countries such as China, alteplase may be too expensive for low-income patients, and also for regions with low economic ...
Rongrong Zhang, Hui Wei, Yu Ren, Yanping Wu, Yetao Luo, Lei Zhang, Yingchao Huo, Jinzhou Feng, Philippe P. Monnier, Philippe P. Monnier, Philippe P. Monnier, Xinyue Qin   +11 more
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Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke: The Comparative Effectiveness of Routine Tenecteplase vs Alteplase in Acute Ischemic Stroke (CERTAIN) Collaboration.

JAMA Neurology, 2023
Importance Symptomatic intracranial hemorrhage (sICH) is a serious complication of stroke thrombolytic therapy. Many stroke centers have adopted 0.25-mg/kg tenecteplase instead of alteplase for stroke thrombolysis based on evidence from randomized ...
S. Warach, A. Ranta, Joosup Kim, Shlee S Song, A. Wallace, J. Beharry, D. Gibson, D. Cadilhac, C. Bladin, T. Kleinig, J. Harvey, L. Palanikumar, V. Doss, Ruth Marescalco, J. Fink, Alicia Tyson, K. Schlick, Lydia Noh, D. Wilson, Sonia Figueroa, M. Pech, Laurie B Paletz, Maya Lewis, Marissa Castro, D. Sahlein, E. F. Lafranchise, Justin Sandall, K. Asif, S. Geraghty, P. Cullis, T. Malisch, Terry A Neill, M. LaMonte, B. Campbell, Teddy Y. Wu   +34 more
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Tenecteplase Thrombolysis in Posterior Circulation Stroke

Frontiers in Neurology, 2021
One in five ischaemic strokes affects the posterior circulation. Basilar artery occlusion is a type of posterior circulation stroke associated with a high risk of disability and mortality.
Fana Alemseged, Bruce C. V. Campbell
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Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2023
Importance Intravenous thrombolysis is increasingly used in patients with minor stroke, but its benefit in patients with minor nondisabling stroke is unknown.
Hui-Sheng Chen, Yu Cui, Zhong-he Zhou, Hong Zhang, Li-Xia Wang, Wei-Zhong Wang, Li-Ying Shen, Li-yan Guo, E. Wang, Ruixian Wang, Jing Han, Yuming Dong, Jing Li, Yongzhong Lin, Qing-Cheng Yang, L. Zhang, Jingye Li, Jin Wang, Lei Xia, Guang-Bin Ma, Jiang Lu, Chang-Hao Jiang, Shuchun Huang, Lishu Wan, Xiang-yu Piao, Zhuo Li, Yan-Song Li, Kui-Hua Yang, Duo-Lao Wang, Thanh N. Nguyen   +29 more
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Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared with intravenous thrombolysis plus endovascular treatment (standard treatment) can achieve similar functional outcomes.
W. Zi, Zhongming Qiu, Fengli Li, Hongfei Sang, Deping Wu, W. Luo, Shuai Liu, Junjie Yuan, Jiaxing Song, Zhonghua Shi, Wenguo Huang, Min Zhang, Wen-hua Liu, Zhangbao Guo, Tao Qiu, Qiang Shi, P. Zhou, Li Wang, Xinmin Fu, Shudong Liu, Shi-quan Yang, Shuai Zhang, Zhiming Zhou, Xianjun Huang, Yan Wang, Jun Luo, Yongjie Bai, Min Zhang, Youlin Wu, Guoyong Zeng, Y. Wan, C. Wen, Hongbin Wen, Wentong Ling, Zhuo Chen, M. Peng, Zhibing Ai, F. Guo, Huagang Li, Jing Guo, Hai-tao Guan, Zhiyi Wang, Yong Liu, J. Pu, Zhen Wang, Hansheng Liu, Luming Chen, Jiacheng Huang, Guoqiang Yang, Zi-li Gong, Jie Shuai, R. Nogueira, Qingwu Yang   +52 more
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A comparison of low- versus standard-dose bridging alteplase in acute ischemic stroke mechanical thrombectomy using indirect methods

Therapeutic Advances in Neurological Disorders, 2023
Background: Whether low-dose alteplase is similar to standard-dose bridging alteplase prior to endovascular mechanical thrombectomy in patients with acute ischemic stroke (AIS) remains uncertain.
Wei Zheng, Hanhan Lei, Gareth Ambler, David J. Werring, Huiying Lin, Xiaojuan Lin, Yi Tang, Jing Wu, Zhaomin Lin, Nan Liu, Houwei Du   +10 more
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