Effect of alteplase on platelet function and receptor expression [PDF]
Journal of International Medical Research, 2019 Objective To investigate the role of alteplase, a widely-used thrombolytic drug, in platelet function. Methods Human platelets were incubated with different concentrations of alteplase followed by analysis of platelet aggregation in response to adenosine
Jun Lu +5 more
doaj +2 more sources
Comparative effectiveness of Tenecteplase and Alteplase for ischemic stroke: real-world data from a stroke center [PDF]
BMC NeurologyBackground Tenecteplase (TNK) and Alteplase (rt-PA) are intravenous thrombolytics used in acute ischemic stroke (AIS). While Alteplase has long been the standard of care, TNK is now also approved for AIS by both the EMA and FDA.
Toska Maxhuni +10 more
doaj +2 more sources
Economic value of extended-window intravenous alteplase in posterior circulation stroke: a Markov analysis based on the EXPECTS trial. [PDF]
Front PharmacolMa Y, Lou Y, Chen M, Zeng Y.
europepmc +3 more sources
Comparative effectiveness and safety of tenecteplase versus alteplase for intravenous thrombolysis in acute ischemic stroke: a retrospective study [PDF]
Frontiers in NeurologyBackgroundTenecteplase has been proposed as a practical alternative to alteplase for intravenous thrombolysis in acute ischemic stroke. Although randomised trials have demonstrated noninferiority, data from real-world comparative cohorts remain limited ...
Weili Zhao +4 more
doaj +2 more sources
Administration of Cilostazol Prior to Intravenous Alteplase for Acute Branch Atheromatous Disease: A Report of Three Cases [PDF]
Case Reports in Neurological MedicinePatients with acute branch atheromatous disease often experience early neurological deterioration (END) in the first 24-h period, even after intravenous alteplase. Three cases treated with cilostazol, a phosphodiesterase 3-inhibitor, prior to intravenous
Eijirou Tanaka +4 more
doaj +2 more sources
Dual antiplatelet versus alteplase in anterior and posterior circulation minor stroke [PDF]
Stroke and Vascular NeurologyObjective The Antiplatelet versus R-tPA for Acute Mild Ischaemic Stroke trial has demonstrated the non-inferiority of dual antiplatelet therapy (DAPT) to alteplase in minor non-disabling stroke.
Yu Cui, Hui-Sheng Chen
doaj +2 more sources
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke [PDF]
New England Journal of Medicine, 2008 Werner Hacke +2 more
exaly +2 more sources
Analysis of hemorrhagic transformation and intracerebral hemorrhage under combination therapy with alteplase and antiplatelets or anticoagulants, using the Japanese Adverse Drug Event Report database. [PDF]
PLoS ONERecombinant tissue-type plasminogen activators (rtPA) effectively dissolve blood clots and improve symptoms in patients with acute ischemic stroke and myocardial infraction.
Tsuyoshi Nakai +6 more
doaj +2 more sources
Tenecteplase versus alteplase for acute ischemic stroke. [PDF]
Cochrane Database Syst RevPrabhakar H +4 more
europepmc +3 more sources
Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta‐Analysis to Determine the Optimal Dose [PDF]
Brain and BehaviorBackground: Tenecteplase (TNK) is a novel thrombolytic agent gaining attention as an alternative to alteplase for treating acute ischemic stroke (AIS).
Muhammad Hassan Waseem +9 more
doaj +2 more sources