Cerebrovascular Diseases Extra, 2017 Background and Purpose: Endovascular thrombectomy (EVT) improves the functional outcome when added to best medical therapy, including alteplase, in patients with acute ischaemic stroke secondary to large vessel occlusion (LVO) in the anterior circulation.
Chee-Keong Wee +7 more
doaj +1 more source
Professional guideline versus product label selection for treatment with IV thrombolysis: an analysis from SITS registry [PDF]
, 2017 Introduction: Thrombolysis usage in ischaemic stroke varies across sites. Divergent advice from professional guidelines and product labels may contribute. Patients and methods: We analysed SITS-International registry patients enrolled January 2010
Alan C Cameron +8 more
core +1 more source
Effect of alteplase on platelet function and receptor expression
Journal of International Medical Research, 2019 Objective To investigate the role of alteplase, a widely-used thrombolytic drug, in platelet function. Methods Human platelets were incubated with different concentrations of alteplase followed by analysis of platelet aggregation in response to adenosine
Jun Lu +5 more
doaj +1 more source
Brain Sciences, 2021 Background: The benefit of alteplase in minor non-disabling acute ischemic stroke (AIS) is unknown. We aimed to explore the clinical efficacy of alteplase-treatment in minor non-disabling stroke in clinical practice.
Wansi Zhong +5 more
doaj +1 more source
Does hemispheric lateralization influence functional and cardiovascular outcomes after stroke?: an analysis of placebo-treated patients from prospective acute stroke trials [PDF]
, 2008 <p><b>Background and Purpose:</b> The influence of stroke lateralization on functional and cardiovascular outcome after stroke is not well established.
Fink, J.N. +3 more
core +1 more source
Neurology and Therapy, 2023 Introduction This study aimed to investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS). Methods In this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis
Mingfeng Zhai +9 more
doaj +1 more source
Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial [PDF]
, 2006 <p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings.
Ashwood, T. +11 more
core +1 more source
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]
, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat +6 more
core +3 more sources
Using alteplase nephrostomy tube installation for thrombolysis of ureter tract clot obstruction
Urology Case Reports, 2021 In literature, few cases have been reported regarding the use of alteplase installation in a nephrostomy as anticoagulant treatment of blood clots in the upper urinary tract.Our case -report provides a unique case of alteplase installation in the ...
Paoyan Lin +2 more
doaj +1 more source
Iodinated contrast media and cerebral hemorrhage after intravenous thrombolysis [PDF]
, 2011 <p>Background and Purpose: Iodinated contrast is increasingly used in CT perfusion or angiographic examinations in acute stroke. Increased risk of intracranial hemorrhage (ICH) complicating microcatheter contrast injections has recently been ...
Evelyn Teasdale +6 more
core +1 more source