Results 31 to 40 of about 28,483 (297)

Safety and Efficacy of Tenecteplase Compared With Alteplase in Patients With Large Vessel Occlusion Stroke: A Prespecified Secondary Analysis of the ACT Randomized Clinical Trial.

JAMA Neurology, 2023
Importance It is unknown whether intravenous thrombolysis using tenecteplase is noninferior or preferable compared with alteplase for patients with acute ischemic stroke.
F. Bala, Nishita Singh, B. Buck, A. Ademola, S. Coutts, Y. Deschaintre, H. Khosravani, R. Appireddy, F. Moreau, Stephen Phillips, G. Gubitz, A. Tkach, L. Catanese, D. Dowlatshahi, G. Medvedev, J. Mandzia, A. Pikula, J. Shankar, H. Williams, Thalia Shoshana Field, Alejandro Manosalva Alzate, Muzaffar M Siddiqui, A. Zafar, Oje Imoukhoude, G. Hunter, Ibrahim Alhabli, F. Benali, MacKenzie Horn, Michael D. Hill, M. Shamy, T. Sajobi, R. Swartz, B. Menon, M. Almekhlafi   +33 more
semanticscholar   +1 more source

Clinical efficacy and safety analysis of argatroban and alteplase treatment regimens for acute cerebral infarction

Journal of Neurorestoratology, 2022
ObjectiveThis study compared the clinical efficacy and safety of argatroban and alteplase in the treatment of acute cerebral infarction.MethodsThis study retrospectively analyzed 131 patients admitted for acute cerebral infarction within 48 h of onset ...
Lifang Xu, Xiaofeng Yang, He Gao, Xin Wang, Bo Zhou, Yan Li, Lin Li, Xiaoling Guo, Liqun Ren   +8 more
doaj   +1 more source

Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.

New England Journal of Medicine, 2008
BACKGROUND Intravenous thrombolysis with alteplase is the only approved treatment for acute ischemic stroke, but its efficacy and safety when administered more than 3 hours after the onset of symptoms have not been established. We tested the efficacy and
W. Hacke, M. Kaste, E. Bluhmki, M. Brozman, A. Dávalos, D. Guidetti, V. Larrue, K. Lees, Z. Medeghri, T. Machnig, D. Schneider, R. von Kummer, N. Wahlgren, D. Toni   +13 more
semanticscholar   +1 more source

Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke.

New England Journal of Medicine, 2020
BACKGROUND In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.
Pengfei Yang, Yongwei Zhang, Lei Zhang, Yongxin Zhang, K. Treurniet, Wenhuo Chen, Ya Peng, Hongxing Han, Jiyue Wang, Shouchun Wang, Congguo Yin, Sheng Liu, Peng Wang, Q. Fang, Hongchao Shi, Jianhong Yang, C. Wen, Conghui Li, Changchun Jiang, Jun Sun, X. Yue, Min Lou, Meng Zhang, Hansheng Shu, Dianjing Sun, Huizhi Liang, Tong Li, F. Guo, Kaifu Ke, Hai-cheng Yuan, Guoping Wang, Weimin Yang, Huaizhang Shi, Tianxiao Li, Zifu Li, P. Xing, Ping Zhang, Y. Zhou, Hao Wang, Yi Xu, Qinghai Huang, Tao Wu, R. Zhao, Qiang Li, Yibin Fang, Laixing Wang, Jianping Lu, Yansheng Li, Jianhui Fu, Xihua Zhong, Yongjun Wang, Longde Wang, M. Goyal, D. Dippel, B. Hong, Benqiang Deng, Y. Roos, C. Majoie, Jianmin Liu   +58 more
semanticscholar   +1 more source

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial [PDF]

, 2017
Background: Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline ...
Adams Jr., Harold P., Adeoye, Opeolu, Aldrich, E. Francois, Ansari, Safdar, Awad, Issam A., Betz, Joshua F., Butcher, Kenneth, Carhuapoma, J. Ricardo, Caron, Jean-Louis, Dawson, Jesse, Diener-West, Marie, Gandhi, Deeraj, Gregson, Barbara, Hanley, Daniel F., Harnof, Sagi, Harrigan, Mark R., Jallo, Jack, Janis, Scott, John, Sayona, Kase, Carlos S., Keyl, Penelope M., Lane, Karen, LeDoux, David, Lees, Kennedy R., Lopez, George A., Mayo, Steven W., McBee, Nichol, Mendelow, A. David, Mould, W. Andrew, Muschelli, John, Rosenblum, Michael, Sugar, Elizabeth A., Thompson, Carol B., Thompson, Richard E., Tuhrim, Stanley, Ullman, Natalie, Vespa, Paul, Wright, David W., Yenokyan, Gayane, Ziai, Wendy, Zuccarello, Mario   +40 more
core   +1 more source

Minor Non-Disabling Stroke Patients with Large Vessel Severe Stenosis or Occlusion Might Benefit from Thrombolysis

Brain Sciences, 2021
Background: The benefit of alteplase in minor non-disabling acute ischemic stroke (AIS) is unknown. We aimed to explore the clinical efficacy of alteplase-treatment in minor non-disabling stroke in clinical practice.
Wansi Zhong, Ying Zhou, Kemeng Zhang, Shenqiang Yan, Jianzhong Sun, Min Lou   +5 more
doaj   +1 more source

Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA) [PDF]

, 2010
<p><b>Background and Purpose:</b> Thrombolysis for acute ischemic stroke in patients aged >80 years is not approved in some countries due to limited trial data in the very elderly.
Bluhmki, E., Diener, H.-C., Lees, K.R., Lyden, P.D., Mishra, N.K.   +4 more
core   +1 more source

Effect of Intravenous Thrombolytic Dose of Alteplase on Long-Term Prognosis in Patients with Acute Ischemic Stroke

Neurology and Therapy, 2023
Introduction This study aimed to investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS). Methods In this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis
Mingfeng Zhai, Shugang Cao, Jinwei Yang, Xiaoyan Cao, Zhong Dong, Wanyin Liu, Yongzhan Fu, Qiyue Guan, Yu Wang, Hongbo Liu   +9 more
doaj   +1 more source

Outcomes of Endovascular Thrombectomy with and without Thrombolysis for Acute Large Artery Ischaemic Stroke at a Tertiary Stroke Centre

Cerebrovascular Diseases Extra, 2017
Background and Purpose: Endovascular thrombectomy (EVT) improves the functional outcome when added to best medical therapy, including alteplase, in patients with acute ischaemic stroke secondary to large vessel occlusion (LVO) in the anterior circulation.
Chee-Keong Wee, William McAuliffe, Constantine C. Phatouros, Timothy J. Phillips, David Blacker, Tejinder P. Singh, Ellen Baker, Graeme J. Hankey   +7 more
doaj   +1 more source

Tenecteplase or Alteplase Better in Patients with Acute Ischemic Stroke Due to Large Vessel Occlusion: A Single Center Observational Study

Medicina, 2022
Background and Objectives: The study aimed to investigate the efficacy of intravenous thrombolysis with Tenecteplase before thrombectomy for acute ischemic stroke (AIS) patients compared with previous results using Alteplase.
Agnete Teivane, Kristaps Jurjāns, Jānis Vētra, Jekaterina Grigorjeva, Karlis Kupcs, Rytis Masiliūnas, Evija Miglāne   +6 more
doaj   +1 more source