Results 41 to 50 of about 20,254 (207)

Statistical analysis of the primary outcome in acute stroke trials [PDF]

, 2012
Common outcome scales in acute stroke trials are ordered categorical or pseudocontinuous in structure but most have been analyzed as binary measures. The use of fixed dichotomous analysis of ordered categorical outcomes after stroke (such as the modified
Altman, H., Bath, P.M.W., Bland, M., Hogg, C., Howard, G., Lees, K.R., Saver, J.L., Schellinger, P.D.   +7 more
core   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

The SITS-UTMOST: a registry-based prospective study in Europe investigating the impact of regulatory approval of intravenous Actilyse in the extended time window (3–4.5 h) in acute ischaemic stroke [PDF]

, 2016
Introduction: The SITS-UTMOST (Safe Implementation of Thrombolysis in Upper Time window Monitoring Study) was a registry-based prospective study of intravenous alteplase used in the extended time window (3–4.5 h) in acute ischaemic stroke to evaluate ...
Ahmed, Niaz, Bluhmki, Erich, Danays, Thierry, Ford, Gary A., Hermansson, Karin, Kenton, Anthony, Lakshmanan, Sekaran, Lees, Kennedy R., Mikulik, Robert, Nunes, Ana Paiva, Toni, Danilo, Wahlgren, Nils   +11 more
core   +1 more source

Argatroban plus alteplase in posterior versus anterior circulation stroke

Annals of Clinical and Translational Neurology
Objective ARAIS trial failed to demonstrate benefit of argatroban as an adjunct to alteplase for stroke. Given differences between anterior circulation stroke (ACS) and posterior circulation stroke (PCS), we performed prespecified secondary analysis to ...
Yu Cui, Hui‐Sheng Chen
doaj   +1 more source

Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase.
Liyuan Wang, Manjun Hao, Na Wu, Shuangzhe Wu, Marc Fisher, Yunyun Xiong   +5 more
doaj   +1 more source

Abstract Number ‐ 259: Recanalization Before Completion of Alteplase Infusion Leads to Improved Outcomes: A Retrospective Analysis

Stroke: Vascular and Interventional Neurology, 2023
Introduction The recently published CHOICE trial found that intra‐arterial infusion of alteplase improved clinical outcomes in patients undergoing EVT for LVO AIS, an effect that was possibly due to a reduction in reperfusion‐related injury.
Ivo Bach, Alexandra L Czap, Deepa Dongarwar, Sunil A Sheth   +3 more
doaj   +1 more source

Predictors for cerebral edema in acute ischemic stroke treated with intravenous thrombolysis [PDF]

, 2017
Cerebral edema (CED) is a severe complication of acute ischemic stroke. There is uncertainty regarding the predictors for the development of CED after cerebral infarction.
Ahmed, Niaz, Azevedo, Elsa, Dawson, Jesse, Egido, Jose A., Falcou, Anne, Ford, Gary A., Holmin, Staffan, Mikulik, Robert, Ollikainen, Jyrki, Thorén, Magnus, Wahlgren, Nils   +10 more
core   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

The budget impact of alteplase in the treatment of acute ischemic stroke in Egypt

Frontiers in Neurology, 2023
IntroductionStroke is the second leading cause of mortality worldwide. Five percent of all the disability-adjusted life years (DALYs) lost around the world are attributed to stroke. This study aimed to assess the economic burden of acute ischemic stroke (
Hany Aref, Nevine El Nahas, Gihan Hamdy Elsisi, Gihan Hamdy Elsisi, Hossam Shokri, Tamer Roushdy   +5 more
doaj   +1 more source

Mismatch-based delayed thrombolysis: a meta-analysis [PDF]

, 2010
<p><b>Background and Purpose</b>: Clinical benefit from thrombolysis is reduced as stroke onset to treatment time increases. The use of "mismatch" imaging to identify patients for delayed treatment has face validity and has been used in
Anthony J. Furlan, Geoffrey A. Donnan, Gregory W. Albers, Kennedy R. Lees, Nishant K. Mishra, Stephen M. Davis, Werner Hacke   +6 more
core   +1 more source