Results 61 to 70 of about 12,417 (199)
Outcome of Treatment with Intravenous Alteplase in Acute Stroke Patients [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2023 Background and Objective: Stroke is one of the main causes of death and disability in the world, and its treatment includes the re-supply of blood to the brain tissue using different methods, including alteplase injection.
H Nemati +5 more
doaj
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, Volume 16, Issue 2, Page 314-330, February 2026.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Central nervous system (CNS) hemorrhage is a serious complication of intravenous thrombolysis. Tenecteplase, a fibrin‐specific thrombolytic agent, has a lower risk of hemorrhage than other agents. We report the first documented case of simultaneous intracranial and spinal hemorrhage following intravenous administration of tenecteplase.
Thamalee Palliyaguru +4 more
wiley +1 more source
Frontiers in NeurologyBackgroundThe Argatroban Plus Recombinant Tissue-Type Plasminogen Activator for AIS (ARAIS) trial failed to demonstrate the benefit of argatroban in patients diagnosed with acute ischemic stroke who were treated with intravenous alteplase.
Yu Cui +3 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Acute pulmonary embolism (PE) is a prevalent cardiovascular condition with significant mortality and morbidity. Treatment strategies vary according to risk stratification. While anticoagulation is sufficient for low‐risk patients, high‐risk cases often necessitate systemic thrombolysis (ST) or surgical embolectomy.
Mohammadreza Motazedian +3 more
wiley +1 more source
Ultrasound-Proven Efficacy of One Dose of Alteplase via Thoracentesis Catheter for a Loculated Malignant Pleural Effusion [PDF]
, 2021 E. Mlodzinski +3 more
openalex +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo +17 more
wiley +1 more source
Research Progress of Ferroptosis in Cerebral Infarction
Brain and Behavior, Volume 16, Issue 1, January 2026.Cerebral infarction triggers ischemia–reperfusion injury, leading to iron overload, oxidative stress, and mitochondrial dysfunction, which together initiate ferroptosis—an iron‐dependent, lipid peroxidation–driven form of neuronal death. Disruption of the System Xc−/GSH/GPX4 antioxidant axis and ACSL4‐mediated PUFA phospholipid enrichment accelerates ...
Yilan Fei, Qi Leng
wiley +1 more source
Effects of alteplase in the treatment of acute ischemic stroke
International Journal of General Medicine, 2012 Josef YayanDepartment of Internal Medicine, Vinzentius Hospital, Landau, GermanyBackground: For the last 15 years, alteplase (recombinant tissue plasminogen activator) has been used widely throughout the world for the treatment of acute ischemic stroke ...
Yayan J
doaj
Journal of Pediatric Critical Care, 2014 Objective:outcome of children treated with Intrapleural alteplase therapy in empyema thoracis Design: Prospective interventional pilot study Setting:Pediatric Critical care and Pulmonology unit at Tertiary care Hospital Subjects: All patients of empyema ...
P K Sharma +5 more
doaj +1 more source