Results 61 to 70 of about 20,254 (207)

A Systematic Review of the Efficacy and Safety of Tenecteplase Versus Alteplase in Acute Ischemic Stroke: A Time to Pass the Torch

Stroke: Vascular and Interventional Neurology
Alteplase, a biosynthetic form of human tissue‐type plasminogen activator, is Food and Drug Administration‐approved for the treatment of acute ischemic stroke and currently the standard of care for thrombolytic therapy.
Miguel Rodriguez, Christian Sidebottom, Drew A. Wells, Thirumalaivasan Dhasakeerthi, Lisa Hayes, Cheran Elangovan, Balaji Krishnaiah   +6 more
doaj   +1 more source

Outcome of Treatment with Intravenous Alteplase in Acute Stroke Patients [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2023
Background and Objective: Stroke is one of the main causes of death and disability in the world, and its treatment includes the re-supply of blood to the brain tissue using different methods, including alteplase injection.
H Nemati, P Saadat, A Ahmadi Ahangar, V Nematian, S Alijanpour, A Bijani   +5 more
doaj  

The Virtual International Stroke Trials Archive [PDF]

, 2007
BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable
Ali, M., Bath, P.M.W., Curram, J., Davis, S.M., Diener, H.-C., Donnan, G.A., Fisher, M., Gregson, B.A., Grotta, J., Hacke, W., Hennerici, M.G., Hommel, M., Kaste, M., Lees, K.R., Marler, J.R., Sacco, R.L., Teal, P., Wahlgren, N.-G., Warach, S., Weir, C.J.   +19 more
core   +3 more sources

Assessment of Socio‐Demographic and Clinical Characteristics of Stroke Patients of a Tertiary Hospital in Bangladesh: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Stroke is a major public health concern with significant socio‐economic implications. Understanding the sociodemographic and clinical characteristics of stroke patients is essential for effective prevention, management, and planning of healthcare services.
Sree Shib Shankar Devnath Debu, Ryadul Alam, Israt Jahan Eti, Dipak Kumar Mitra   +3 more
wiley   +1 more source

Early recurrent ischemic stroke complicating intravenous thrombolysis for stroke: incidence and association with atrial fibrillation [PDF]

, 2010
<p><b>Background and Purpose:</b> Mechanisms of early neurologic deterioration after treatment with intravenous, recombinant, tissue-type plasminogen activator (IV rt-PA) include symptomatic intracerebral hemorrhage (SICH) and early ...
Awadh, M., Baird, T., MacDougall, N., Muir, K.W., Santosh, C., Teasdale, E.   +5 more
core   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Association between time to reperfusion and outcome is primarily driven by the time from imaging to reperfusion [PDF]

, 2016
Background and Purpose A progressive decline in the odds of favorable outcome as time to reperfusion increases is well known. However, the impact of specific workflow intervals is not clear.; Methods We studied the mechanical thrombectomy group (n=103 ...
Cerda, Neus, Cobo Valeri, Erik, Dávalos Errando, Antoni, Jovin, Tudor G., Molina, Carlos A., Ribó, Marc, Sanroman, Luis, Tomasello, Alejandro, Urra, Xabier   +8 more
core   +2 more sources

A Parallel Group, 1:1 Randomised, Pilot Study Comparing the Clinical Efficacy and Bleeding Risk Between Low Dose and Standard Dose Intrapleural Tissue Plasminogen Activator for Adults With Pleural Infection

Respirology Case Reports, Volume 14, Issue 4, April 2026.
This protocol is for the TRAPPE study, a pilot study to serve as preparatory work before proceeding to a full‐scale, multicentre RCT. The feasibility of the study design involving flexibility of dose escalation and various clinical parameters will be tested for suitability as study outcome measurements before proceeding to a full‐scale RCT.
Ken Ka Pang Chan, Christopher Chan, David Shu Cheong Hui, Ai Ling Tan, Y. C. Gary Lee   +4 more
wiley   +1 more source

Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment [PDF]

, 2015
Background Individualised prediction of outcomes can support clinical and shared decision making. This paper describes the building of such a model to predict outcomes with and without intravenous thrombolysis treatment following ischaemic stroke ...
A Bannat, D Kraft, F Bernardini, J Aleotti, J Ilonen, J Prankl, M Krainin, SM Olesen   +7 more
core   +2 more sources

Comment on: Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke—The 24‐h Time‐Point May be a Pro‐Thrombotic Blind Spot: Check 6‐h Fibrinogen Rebound to Catch Early Re‐Occluders

Annals of Clinical and Translational Neurology, EarlyView.
Qichao Fang, Luting Ying, Yongjin Gong
wiley   +1 more source