Results 81 to 90 of about 20,254 (207)

Intrapleural fibrinolytic therapy with alteplase in empyema thoracis in children - A prospective pilot study

Journal of Pediatric Critical Care, 2014
Objective:outcome of children treated with Intrapleural alteplase therapy in empyema thoracis Design: Prospective interventional pilot study Setting:Pediatric Critical care and Pulmonology unit at Tertiary care Hospital Subjects: All patients of empyema ...
P K Sharma, B Saikia, R Sharma, P Jain, Z Hussain, P Khilnani   +5 more
doaj   +1 more source

Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]

, 2017
Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver, Blyth, Kevin G., De Fonseka, Duneesha, Edey, Anthony, Lee, Y. C. Gary, Martin, Geoffrey, Maskell, Nick, Piccolo, Francesco, Popowicz, Natalia, Smith, Nicola A., Wong, Donny   +10 more
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, Volume 16, Issue 2, Page 314-330, February 2026.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Comparing Efficacy and Safety of Bridging Therapy Versus Endovascular Thrombectomy in Acute Basilar Artery Occlusion: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 2, February 2026.
The meta‐analysis compares bridging therapy to endovascular thrombectomy in acute basilar artery occlusion, finding that EVT+IVT provides significant functional benefits, lowers mortality risk, and does not increase hemorrhage risk compared to EVT alone, with similar recanalization success rates for both treatments.
Muhammad Hassan Waseem, Zain ul Abideen, Aiman Waheed, Sanan Rasheed, Muneeba Ahsan, Rimsha Adnan, Muhammad Wajih Ansari, Rowaid Ahmad, Zara Fahim, Pawan Kumar Thada, Brandon Lucke‐Wold, Adam A. Dmytriw   +11 more
wiley   +1 more source

Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial

Stroke and Vascular Neurology
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are common but often progress, leaving patients with significant disability.
Dar Dowlatshahi, Mohammed A Almekhlafi, Tolulope Sajobi, Aleksandra Pikula, Ashfaq Shuaib, Alexandre Y Poppe, Richard H Swartz, Fouzi Bala, Ibrahim Alhabli, Aleksander Tkach, Heather Williams, Shelagh B Coutts, Nishita Singh, Anurag Trivedi, Andrew Demchuk, Gary Hunter, Brian H Buck, Faysal Benali, Bijoy Menon, MacKenzie Horn, Radhika Nair, Thalia Field, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Ayoola Ademola, Houman Khosravani, Herbert Alejandro Manosalva Alzate, Luciana Catanese   +28 more
doaj   +1 more source

No relation between body temperature and arterial recanalization at three days in patients with acute ischaemic stroke [PDF]

, 2015
Background: Recanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.
Bakker, S.L.M. (Stef), Bienfait, H.P. (Henri), Biessels, G.J., Biessels, G.J. (Geert Jan), Boiten, J. (Jelis), Bot, J. (Joseph), Dankbaar, J.W. (Jan), Dijk, E.J. (Ewoud) van, Dippel, D.W.J. (Diederik), Droogh-De Greve, K.E., Duijm, L.E.M. (Lucien), Duyndam, A. (Anita), Geurts, M. (Marjolein), Graaf, Y. (Yolanda) van der, Hofmeijer, J., Horsch, A.D. (Alexander D.), Horsch, A.D. (Alexander D.), Kappelle, L.J., Kappelle, L.J. (Jaap), Keizer, K. (Koos), Kesselring, A.M. (Anouk), Kort, P.L.M. (Paul) de, Kwa, V.I.H., Lugt, A. (Aad) van der, Luitse, J.S.K., Lycklama à Nijeholt, G.J. (Geert), Majoie, C.B. (Charles), Mali, W.P. (Willem), Meijer, F.J. (F.), Niesten, J.M. (Joris), Pleiter, C.C. (C.), Rooij, W.J. (W.) van, Roos, Y.B.W.E.M. (Yvo), Schaaf, I.C. (Irene) van der, Schonewille, W.J. (Wouter), Seeters, T. (Tom) van, Velthuis, B.K. (Birgitta), Visser, M.C. (Marieke), Vos, J.A. (Jan Albert), Walderveen, M.A.A. (Marianne) van, Wermer, M.J.H. (Marieke), Worp, H.B. (Bart) van der   +41 more
core   +1 more source

Simultaneous Intracranial and Spinal Hemorrhage Following Tenecteplase Thrombolysis for ST‐Elevation Myocardial Infarction: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Central nervous system (CNS) hemorrhage is a serious complication of intravenous thrombolysis. Tenecteplase, a fibrin‐specific thrombolytic agent, has a lower risk of hemorrhage than other agents. We report the first documented case of simultaneous intracranial and spinal hemorrhage following intravenous administration of tenecteplase.
Thamalee Palliyaguru, Pramith Ruwanpathirana, Praveen Weeratunga, Mythily Aravinthan, Thashi Chang   +4 more
wiley   +1 more source

Eficacia y seguridad del tenecteplase en el tratamiento del ACV isquémico agudo

Acta Neurológica Colombiana, 2020
El alteplase es el único fibrinolítico actualmente autorizado en Colombia para el tratamiento del ACV isquémico agudo. El tenecteplase constituye una nueva alternativa de tratamiento en esta enfermedad al ofrecer mejor perfil farmacológico, mayor ...
Javier Francisco Torres Zafra, Germán Enrique Pérrez Romero   +1 more
doaj   +1 more source

Predictors of the unfavorable outcomes in acute ischemic stroke patients treated with alteplase, a multi-center randomized trial

Scientific Reports
Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients.
Mohamed G. Zeinhom, Mohamed Fouad Elsayed Khalil, Islam Fathallah Mohamed Kamel, Ahmed Mohamed Kohail, Sherihan Rezk Ahmed, Ahmed Elbassiouny, Ashfaq Shuaib, Omar M Al-Nozha   +7 more
doaj   +1 more source

Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials [PDF]

, 2005
<p><b>Background and Purpose:</b> Acute stroke trials typically use disability scales as their primary end point. Neurologic impairment scales such as the National Institutes of Health Stroke Scale (NIHSS) are possibly more sensitive to
Lees, K.R., Weir, C.J., Young, F.B.
core   +1 more source