Results 81 to 90 of about 28,483 (297)

Tenecteplase versus alteplase for patients with acute ischemic stroke: a meta-analysis of randomized controlled trials

Aging, 2023
Tenecteplase (TNK), a newer fibrinolytic agent with greater fibrin specificity and longer half-life than alteplase, may has practical advantages over alteplase in acute ischemic stroke (AIS) thrombolysis.
Xu Zhang, Teng-Fei Wan, Jing Chen, Liang Liu   +3 more
semanticscholar   +1 more source

Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) [PDF]

, 2009
<p><b>Background and Purpose:</b> The optimal management of blood pressure (BP) in acute stroke remains unclear. For ischemic stroke treated with intravenous thrombolysis, current guidelines suggest pharmacological intervention if ...
Ahmed, N., Ford, G.A., Kaste, M., Lees, K.R., Toni, D.   +4 more
core   +1 more source

Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE): A multicentre, prospective, randomized, open-label, blinded-endpoint, controlled phase III non-inferiority trial protocol

International Journal of Stroke, 2023
Rationale: Alteplase is the only approved thrombolytic agent for acute stroke. An alternative plasminogen activator, tenecteplase, has been previously shown to increase early biological effectiveness (reperfusion) resulting in early clinical recovery in ...
A. Bivard, C. Garcia-Esperon, L. Churilov, N. Spratt, M. Russell, B. Campbell, P. Choi, T. Kleinig, Henry Ma, H. Markus, Carlos A Molina, C. Hsu, Chon-Haw Tsai, A. Meretoja, D. Strbian, K. Butcher, Teddy Y. Wu, S. Davis, G. Donnan, C. Levi, M. Parsons   +20 more
semanticscholar   +1 more source

Comparison of predictive scores of symptomatic intracerebral haemorrhage after stroke thrombolysis in a single centre [PDF]

, 2015
Peer reviewedPublisher ...
Dai, D., MacLeod, MJ, Reid, J. M., Watson-Fargie, T.   +3 more
core   +1 more source

Health and economic benefits of improving pre‐hospital identification of stroke in Australian women: a modelling study

Medical Journal of Australia, EarlyView.
Abstract Objective To estimate the long term gains in life years and quality‐adjusted life years (QALYs) and the cost savings that could be achieved if ischaemic stroke was identified in women with the same level of accuracy received by men, versus the status quo. Design Decision tree and Markov model decision analysis.
Thomas Gadsden, Lei Si, Emily R Atkins, Cheryl Carcel, Xia Wang, Stephen Jan, Mark Woodward, Laura E Downey   +7 more
wiley   +1 more source

Age and sex affect the association of systolic blood pressure with clinical outcomes in thrombolysed stroke patient: a secondary analysis of the INTRECIS study

Frontiers in Neurology, 2023
Background and purposeBlood pressure is associated with outcomes in acute ischemic stroke (AIS) patients receiving intravenous alteplase. The study aimed to explore the effect of sex and age on their association.MethodsBased on a prospective cohort, we ...
Bai-Jun Liu, Jing Li, Hui-Sheng Chen
doaj   +1 more source

Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase.

Journal of the American Medical Association (JAMA), 2022
Importance Current guidelines recommend against use of intravenous alteplase in patients with acute ischemic stroke who are taking non-vitamin K antagonist oral anticoagulants (NOACs).
Wayneho Kam, D. Holmes, Adrian F. Hernandez, J. Saver, G. Fonarow, Eric E. Smith, Deepak L. Bhatt, L. Schwamm, M. Reeves, Roland A. Matsouaka, Yosef M. Khan, M. Unverdorben, M. Birmingham, P. Lyden, A. Asimos, Dorothea Altschul, Tim L. Schoonover, M. Jumaa, J. Nomura, M. Suri, S. Moore, E. Lafranchise, Daiwai M. Olson, E. Peterson, Y. Xian   +24 more
semanticscholar   +1 more source

Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment [PDF]

, 2015
Background Individualised prediction of outcomes can support clinical and shared decision making. This paper describes the building of such a model to predict outcomes with and without intravenous thrombolysis treatment following ischaemic stroke ...
A Bannat, D Kraft, F Bernardini, J Aleotti, J Ilonen, J Prankl, M Krainin, SM Olesen   +7 more
core   +2 more sources

The Added Benefit of Intra‐Arterial Thrombolysis After Successful Recanalization by Endovascular Treatment: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Clinical Trials

European Journal of Neurology, Volume 32, Issue 7, July 2025.
ABSTRACT Background Despite successful recanalization following endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with large‐vessel occlusion (LVO), many patients fail to achieve excellent functional outcomes. Post‐EVT intra‐arterial thrombolysis (IAT) has emerged as a potential adjunctive strategy to improve microvascular reperfusion and
Lina Palaiodimou, Nikolaos M. Papageorgiou, Guillaume Turc, Benjamin Gory, Aikaterini Theodorou, Eleni Bakola, George Magoufis, Stavros Spiliopoulos, Michail Mantatzis, Nitin Goyal, Marios Themistocleous, Amrou Sarraj, Aristeidis H. Katsanos, Urs Fischer, Andrei V. Alexandrov, Georgios Tsivgoulis   +15 more
wiley   +1 more source

Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]

, 2017
Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver, Blyth, Kevin G., De Fonseka, Duneesha, Edey, Anthony, Lee, Y. C. Gary, Martin, Geoffrey, Maskell, Nick, Piccolo, Francesco, Popowicz, Natalia, Smith, Nicola A., Wong, Donny   +10 more
core   +1 more source