Results 91 to 100 of about 3,830,833 (311)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Development, implementation and evaluation of satellite-aided agricultural monitoring systems [PDF]

open access: yes
Research supporting the use of remote sensing for inventory and assessment of agricultural commodities is summarized. Three task areas are described: (1) corn and soybean crop spectral/temporal signature characterization; (2) efficient area estimation ...
Cicone, R.   +3 more
core   +1 more source

Assessment for learning: the differing perceptions of tutors and students [PDF]

open access: yes, 2001
The purpose of this study was to describe assessment practices as these were experienced by tutors and students in one higher education establishment. Eighty members of faculty staff (80% return) and 130 3rd-year undergraduates (100% return) completed a ...
Maclellan, Effie
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Extended Product Responsibility: An Economic Assessment of Alternative Policies [PDF]

open access: yes
Extended Product Responsibility embodies the notion that agents along a product chain should share responsibility for the life-cycle environmental impacts of the product, including those associated with ultimate disposal. Extended Producer Responsibility
Palmer, Karen, Walls, Margaret
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Practical steps to integrate life cycle thinking into alternative assessment

open access: yesSustainability Science and Technology
Current alternative assessment (AA) methods for chemicals have yet to be completed from the entire life cycle perspective. Conventionally, AA efforts compare chemical alternatives by examining toxicity, hazard, exposure, and physicochemical properties to
John D Chea, Michael A Gonzalez
doaj   +1 more source

An assessment of alternative lender of last resort schemes [PDF]

open access: yes
We sketch a theoretical framework for comparing the properties of funded LOLR schemes. We construct an idealized lender of last resort and investigate how it formulates policy under alternative public and private governance structures.
Herrala, Risto
core  

Processing strategies. QLIF subproject 5: Development of a framework for the design of minimum and low input processing strategies, that guarantee food quality and safety [PDF]

open access: yes, 2009
Organic processing standards already prohibit the use of many chemicals, additives and preservatives, which are used in the processing of conventional foods.
Kretzschmar, U.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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