Results 281 to 290 of about 539,466 (329)

Faculty Opinions recommendation of Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2020
Richard Smith
semanticscholar   +1 more source

The spectrum of complement alternative pathway‐mediated diseases

Immunological Reviews, 2008
Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
openaire   +2 more sources

Polyions regulate the alternative amplification pathway of complement

Immunopharmacology, 1983
Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
openaire   +2 more sources

Alternative complement pathway activation in thrombotic microangiopathy associated with lupus nephritis

Clinical Rheumatology, 2020
J. Mejía-Vilet, I. Gómez-Ruiz, C. Cruz, R. A. Méndez-Pérez, Roque A. Comunidad-Bonilla, N. Uribe-Uribe, C. Núñez-Álvarez, L. Morales-Buenrostro   +7 more
semanticscholar   +1 more source

Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy

Pediatric nephrology (Berlin, West), 2018
M. Noris, R. Donadelli, G. Remuzzi
semanticscholar   +1 more source

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Nature Reviews Drug Discovery, 2020
Anwesha Dey, Xaralabos Varelas, Kun-Liang Guan   +2 more
exaly  

The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes

Thrombosis and Haemostasis, 2016
E. Hertle, I. Arts, C. J. Kallen, E. Feskens, C. Schalkwijk, C. Stehouwer, Marleen M.J. Greevenbroek   +6 more
semanticscholar   +1 more source

Ultralarge von Willebrand factor-induced platelet clumping and activation of the alternative complement pathway in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndromes.

Hematology/Oncology Clinics of North America, 2015
N. Turner, S. Sartain, J. Moake
semanticscholar   +1 more source

Alternative complement pathway activity in cystic fibrosis

The Journal of Pediatrics, 1977
R K, Lyrene, R B, Polhill, L A, Guthrie, R E, Tiller   +3 more
openaire   +2 more sources

Alternate complement pathways.

Progress in allergy, 1974
A G, Osler, A L, Sandberg
openaire   +1 more source