Results 291 to 300 of about 343,845 (337)

Gangliosides can activate human alternative complement pathway

International Immunology, 1993
The alternative complement pathway (ACP) in vertebrates is known to be important in inflammatory reactions, and to be activated by foreign substances such as bacterial lipopolysaccharide (LPS) and zymosan, although to date no intrinsic activators have been identified except complement receptor type 2.
H, Oshima, G, Soma, D, Mizuno
openaire   +2 more sources

[The alternative complement pathway].

Pathologie-biologie, 1984
The alternative complement pathway comprises three component proteins C3, B, D and three regulatory proteins P, H and I. These plasma proteins represent the major humoral defense mechanism against infection in a non-immune host. The following topics are reviewed: biochemistry of the alternative pathway proteins; molecular mechanisms of activation and ...
M H, Jouvin, M, Kazatchkine
openaire   +1 more source

Alternative complement pathway: Activity levels in allogeneic pregnancy

Experientia, 1976
Classical and alternative complement pathway activities have been evaluated in sera of women in progressive stages of gestation and in pregnant mice belonging to outbred or inbred matings, as compared to suitable controls. While classical C pathway was found to be unmodified, the alternative one attained in pregnancy significantly higher activity ...
M, Brai, G, Tolone, A, Magro, H, Waks, M, Brai   +4 more
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[Alternative complement pathway (author's transl)].

La Nouvelle presse medicale, 1979
The dual role of the alternative complement pathway in recognition of foreign substances by a non-immune host and in the intrinsic regulation of the complement sequence is now well recognized. Activation of this pathway occurs through escape from its regulatory mechanisms induced by the activating principle; its functional expression depends on the ...
M, Kazatchkine, U, Nydegger, D T, Fearon
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Restriction of alternative complement pathway activation by sialosylglycolipids

Nature, 1982
Although sheep erythrocytes do not activate the alternative complement pathway (ACP) of human serum, the erythrocytes gain a capacity to activate human ACP following removal of membrane sialic acid by neuraminidase treatment1–3. Therefore, asialoglycoconjugates generated from sialosylglycoconjugates by neuraminidase treatment might be responsible for ...
N, Okada, T, Yasuda, H, Okada
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Complement Fixation by Aggregated IgE through Alternate Pathway

The Journal of Immunology, 1972
Summary Nonspecifically aggregated E myeloma protein fixed late component(s) of guinea pig and human C. Evidence was presented that the C fixation by the aggregate probably goes through an alternate pathway. Comparisons among aggregated Fc, aggregated F(ab′)2 and aggregated IgE with respect to the C-fixing activity showed that aggregated
T, Ishizaka, C M, Sian, K, Ishizaka
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The spectrum of complement alternative pathway‐mediated diseases

Immunological Reviews, 2008
Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
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Polyions regulate the alternative amplification pathway of complement

Immunopharmacology, 1983
Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
openaire   +2 more sources

The adenosine pathway in immuno-oncology

Nature Reviews Clinical Oncology, 2020
Bertrand Allard, Laurence Buisseret, John Stagg   +2 more
exaly  

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Nature Reviews Immunology, 2021
Alexiane Decout, Andrea Ablasser
exaly