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Thermoresponsive BrushGel Microcarriers for Efficient Cell Expansion and Enzyme‐Reduced Harvesting
Askari et al, report on temperature‐responsive microcarriers to minimize enzyme use and cost in dynamic cultures. Abstract Scaling up cell therapy requires efficient expansion of high‐quality cells. Microcarrier(MC)‐based systems offer high surface‐to‐volume ratios and reduce culture media usage.
Esfandyar Askari+9 more
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The alternative complement pathway regulates pathological angiogenesis in the retina.
Sweigard JH+8 more
europepmc +1 more source
Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem. [PDF]
Bierer JD+8 more
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The complement alternative pathway and hemostasis
Immunological Reviews, 2022SummaryThe complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury.
Marina Noris, Miriam Galbusera
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Alternative Complement Pathway in Schizophrenia [PDF]
In the present study, we evaluated functional activity of the alternative pathway of complement in schizophrenia by measuring the alternative pathway hemolytic activity (AH50) of complement as well as hemolytic activity of the complement C3 component (C3H50) in the blood of patients with schizophrenia and healthy subjects.
Andranik Chavushyan+2 more
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The alternative pathway of complement
Springer Seminars in Immunopathology, 1984The alternative pathway of complement activation provides the host with a humoral component of the natural defense mechanisms against infectious agents. The six plasma proteins involved in recognition and activation perform a continuous surveillance function that does not require specific antibody to recognize potential pathogens.
Michael K. Pangburn+1 more
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The Complement Alternative Pathway and Preeclampsia
Current Hypertension Reports, 2018Significant and intricate immune adaptations are essential for the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid, potentially life-threatening disease for both mother and neonate that occurs uniquely in pregnancy, at least in part, due to maternal immune maladaptation.
Layan Alrahmani, Maria Alice V. Willrich
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Abnormalities in the alternative pathway of complement in psoriasis
Clinical and Experimental Dermatology, 1982Summary Some of the immunologic aspects of psoriasis suggest that complement may be involved in the pathophysiology of that disease. The purpose of this work was to examine the complement system in more detail in 20 patients with psoriasis. Classical pathway determinations, RCH50 and factor B levels were normal or elevated.
Joan R.Urmson+7 more
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The alternative pathway of complement and the thrombotic microangiopathies
Transfusion and Apheresis Science, 2016Thrombotic microangiopathies (TMA) are disorders defined by microangiopathic hemolytic anemia, non-immune thrombocytopenia and have multi-organ involvement including the kidneys, brain, gastrointestinal, respiratory tract and skin. Emerging evidence points to the central role of complement dysregulation in leading to microvascular endothelial injury ...
Chia Wei Teoh+2 more
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Alternative pathway of complement in multiple myeloma
American Journal of Hematology, 1981AbstractThe alternative pathway of complement was studied in 16 newly diagnosed and 2 previously treated patients with multiple myeloma. Functional activity of this pathway was abnormal in 10 of these 18 patients (55%). These abnormalities correlated with depressed levels of alternative pathway components in 3 of 10 patients, but in the remaining 7, no
Eric H. Kraut, Arthur L. Sagone
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