Results 331 to 340 of about 475,028 (370)
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Activation of the alternative pathway of complement by microcrystalline cholesterol

Atherosclerosis, 1980
Microcrystalline cholesterol in either the anhydrous or monohydrate form was a potent activator of the alternative pathway of complement as measured by the electrophoretic conversion (crossed immunoelectrophoresis) of C3 and properdin factor B. Chelation with 0.01 M ethylene-diaminetetraacetate (EDTA) completely eliminated conversion, but 0.01 M ...
Jeanie L. Hahn, Peter Hasselbacher
openaire   +3 more sources

The spectrum of complement alternative pathway‐mediated diseases

Immunological Reviews, 2008
Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
openaire   +2 more sources

Alternative Modes and Pathways of Complement Activation

1977
Complement (C) originally was detected by its ability to bring about cytolysis of antibody-sensitized bacteria and erythrocytes. Its name is derived from this ability to complement certain reactivities initiated by antibody. At least eleven С proteins, acting sequentially, are involved in mediating the usual antibody-initiated hemolysis. These proteins
Henry Gewurz, Thomas F. Lint
openaire   +2 more sources

Polyions regulate the alternative amplification pathway of complement

Immunopharmacology, 1983
Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
openaire   +3 more sources

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980
Publisher Summary This chapter presents the proteins of the alternative pathway and their special properties as enzymes, enzyme substrates, and regulators. The participation with the classical pathway components, C5–C9, in membrane attack is considered.
Robert D. Schreiber   +1 more
openaire   +3 more sources

Alternative complement pathway activation in thrombotic microangiopathy associated with lupus nephritis

Clinical Rheumatology, 2020
J. Mejía-Vilet   +7 more
semanticscholar   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Paulo Cáceres Guido   +2 more
exaly  

The alternative complement pathway in chickens

Developmental & Comparative Immunology, 1983
Leif Kongerslev   +2 more
openaire   +2 more sources

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