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Activation of the alternative pathway of complement by microcrystalline cholesterol
Atherosclerosis, 1980Microcrystalline cholesterol in either the anhydrous or monohydrate form was a potent activator of the alternative pathway of complement as measured by the electrophoretic conversion (crossed immunoelectrophoresis) of C3 and properdin factor B. Chelation with 0.01 M ethylene-diaminetetraacetate (EDTA) completely eliminated conversion, but 0.01 M ...
Jeanie L. Hahn, Peter Hasselbacher
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The spectrum of complement alternative pathway‐mediated diseases
Immunological Reviews, 2008Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2020
Richard Smith
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Richard Smith
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Alternative Modes and Pathways of Complement Activation
1977Complement (C) originally was detected by its ability to bring about cytolysis of antibody-sensitized bacteria and erythrocytes. Its name is derived from this ability to complement certain reactivities initiated by antibody. At least eleven С proteins, acting sequentially, are involved in mediating the usual antibody-initiated hemolysis. These proteins
Henry Gewurz, Thomas F. Lint
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Polyions regulate the alternative amplification pathway of complement
Immunopharmacology, 1983Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
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Molecular Biology and Chemistry of the Alternative Pathway of Complement
1980Publisher Summary This chapter presents the proteins of the alternative pathway and their special properties as enzymes, enzyme substrates, and regulators. The participation with the classical pathway components, C5–C9, in membrane attack is considered.
Robert D. Schreiber +1 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Paulo Cáceres Guido +2 more
exaly
The alternative complement pathway in chickens
Developmental & Comparative Immunology, 1983Leif Kongerslev +2 more
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