Results 61 to 70 of about 165,825 (257)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

From the Qualities of Products to the Qualities of Relations: Value Conventions in the Solidarity Economy in Sicily

Valuation Studies, 2019
This article explores the “quality battlefield” in the food economy – the dispute over value conventions between mainstream business actors and alternative food networks. It shows how actors in one particular alternative network – the solidarity economy –
Mihai Varga
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hidden in Plain Sight: Learning from Chinatown’s Produce Distribution System

Journal of Agriculture, Food Systems, and Community Development, 2019
First paragraph: New York’s Chinatown has a century-old produce distribution system that supplies the city with more than 200 types of extremely low-cost fresh fruits and vegetables that are sourced from hundreds of small- and midsize biodiverse farms
Nevin Cohen
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Potential, precarity and persistence: What British Columbia’s Food Hub Network tells us about resilient food systems

Journal of Agriculture, Food Systems, and Community Development
Food systems are increasingly complex and face threats from interconnected shocks with cascading effects. There is a need for strategies that increase food system resilience, including food hubs—a type of alternative food network that aims to enhance ...
Lindsay Harris, Damon Chouinard, Sarah-Patricia Breen   +2 more
doaj   +3 more sources

Welfare and Market Impacts of Food Safety Measures in China: Results from Urban Consumers' Valuation of Product Attributes

Journal of Integrative Agriculture, 2014
This study provides an economics assessment of various food safety measures in China. A choice experiment approach is used to elicit Chinese consumer preferences for various food safety attributes using data from a 2008 urban consumer survey.
David L. Ortega, H. Holly Wang, Nicole J. Olynk Widmar   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cultivating Alliances: The Local Organic Food Co-ops Network

Canadian Journal of Nonprofit and Social Economy Research, 2015
Although social movements can lose their way in neoliberal times, building alliances can help them to leverage their strengths and overcome their weaknesses, thus avoiding co-optation and “mission drift.” One example of this strategy can be found within ...
Jennifer Sumner, Cassie Wever
doaj   +1 more source

Alternative food networks and opportunities for transformation towards a sustainable and resilient urban food system

, 2019
Food systems are suffering from pressures related to population growth, increased urbanisation, climate change, and resource scarcity. These pressures are exacerbated by globalisation, with consumers concentrated in urban areas while producers are ...
Howes, Michael, Serrao-Neumann, Silvia, Canal Vieira, Leticia   +2 more
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